ACE Inhibitors Mechanism of Action

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Questions and Answers

What is the primary mechanism by which ACE inhibitors decrease blood pressure?

  • Vasodilation leading to decreased total peripheral resistance (correct)
  • Decreased release of aldosterone leading to promote renal excretion of sodium and water
  • Inhibition of angiotensin II’s action on vascular growth
  • Inhibition of renin release

Which of the following is NOT a mechanism of action of ACE inhibitors?

  • Inhibition of angiotensin II’s action on vascular growth
  • Inhibition of bradykinin metabolism
  • Decreased release of aldosterone leading to promote renal excretion of sodium and water
  • Stimulation of the sympathetic nervous system (correct)

What is the most likely cause of dry cough in patients taking ACE inhibitors?

  • Inhibition of angiotensin II’s action on vascular growth
  • Decreased aldosterone release
  • Increased bradykinin (correct)
  • Inhibition of bradykinin metabolism

Which of the following is a potential adverse effect of ACE inhibitors?

<p>Hyperkalemia (A)</p> Signup and view all the answers

What is the mechanism by which ACE inhibitors promote renal excretion of sodium and water?

<p>Decreased release of aldosterone (A)</p> Signup and view all the answers

Why may ACE inhibitors need to be changed to ARBs in some patients?

<p>Due to dry cough (D)</p> Signup and view all the answers

What is the mechanism of action of Angiotensin II Receptor Blockers (ARBs) in reducing blood pressure?

<p>Blockage of AT1 receptors (B)</p> Signup and view all the answers

Which of the following diuretics is a competitive antagonist of aldosterone receptors at distal tubule and collecting ducts?

<p>Spironolactone (B)</p> Signup and view all the answers

What is the mechanism of action of Sacubitril + Valsartan in reducing blood pressure?

<p>Inhibition of neprilysin enzyme (C)</p> Signup and view all the answers

What is the common side effect of beta-adrenoreceptor blockers that is not seen with ACE inhibitors?

<p>Fatigue (D)</p> Signup and view all the answers

Which of the following medications is an inhibitor of phosphodiesterase Type II?

<p>Milrinone (C)</p> Signup and view all the answers

What is the mechanism of action of Loop Diuretics in reducing blood pressure?

<p>Inhibition of Na+/K+/2Cl- cotransport system (C)</p> Signup and view all the answers

Which of the following medications is a Beta-1 selective blocker?

<p>Bisoprolol (C)</p> Signup and view all the answers

What is the mechanism of action of Ivabradine in reducing heart rate?

<p>Blockage of funny channel (D)</p> Signup and view all the answers

What is the common side effect of Angiotensin Receptor Neprilysin Inhibitors (ARNI) that is not seen with ACE inhibitors?

<p>Phosphenes (A)</p> Signup and view all the answers

What is the mechanism of action of Cardiac Glycosides in increasing cardiac contractility?

<p>Inhibition of Na+/K+ ATPase (D)</p> Signup and view all the answers

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