16 Questions
What is the absorption pathway for substances administered sublingually or buccally?
They are absorbed directly through the mucous membranes in the mouth and then enter the jugular vein.
What happens to the tablet's contents after entering the portal vein?
They are transported to the liver for processing and metabolism.
How do oral tablets enter the arterial circulation to disperse throughout the body?
After reaching the heart, they are pumped into the arterial circulation.
What is the role of the inferior vena cava in the absorption pathway of buccal or sublingual substances?
It transports the substances to the heart for distribution throughout the body.
What is the pH range of saliva that influences the ionization of weak acid or weak base drugs?
5.6-7.6
What type of drugs can't go through the lipid membrane of the mouth for absorption?
Highly ionized drugs
What is the main reason for using the Henderson-Hasselbalch equation in drug absorption?
To calculate the proportion of ionized drug based on the pH and pKa of the drug
What is the main formulation consideration for sublingual tablets?
Rapid disintegration and dissolution
What is the impact of nitroglycerin's low melting point and high vapor pressure on its stability?
Potential loss of content uniformity and potency
What is the main reason for avoiding excess saliva production with buccal tablets?
To prevent rapid disintegration and absorption
What is the purpose of using layers in the formulation of certain tablets?
To separate incompatible ingredients and provide immediate or sustained release
What is the main reason for using mucoadhesive properties in certain tablets?
To keep the tablet at the administration site
What is the primary reason for avoiding rapid disintegration in buccal tablets?
To ensure gradual dissolution and absorption
What is the main reason for using effervescent tablets?
To dissolve in water for administration
What is the primary consideration for chewable tablets?
Good taste and sweetness
What type of drug release is desired for drugs that are metabolized or not absorbed in the gastrointestinal tract?
0-order release
Test your knowledge of the absorption pathway for buccal and sublingual oral tablets with this quiz. Explore how these tablets travel through the gastrointestinal (GI) tract and enter the bloodstream via the superior mesenteric vein and portal vein.
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