Absorption Pathway Quiz
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Questions and Answers

What is the absorption pathway for substances administered sublingually or buccally?

  • They are absorbed through the small intestine and then enter the portal vein.
  • They are absorbed directly through the mucous membranes in the mouth and then enter the jugular vein. (correct)
  • They are absorbed in the stomach and then enter the inferior vena cava.
  • They are absorbed in the liver and then enter the arterial circulation.

    • What happens to the tablet's contents after entering the portal vein?

  • They are absorbed directly into the bloodstream.
  • They are transported to the heart for distribution throughout the body.
  • They are pumped into the arterial circulation.
  • They are transported to the liver for processing and metabolism. (correct)

    • How do oral tablets enter the arterial circulation to disperse throughout the body?

  • After reaching the heart, they are pumped into the arterial circulation. (correct)
  • They bypass the heart and directly enter the arterial circulation from the liver.
  • They enter the arterial circulation through the inferior vena cava.
  • They are absorbed into the arterial circulation in the lungs.

    • What is the role of the inferior vena cava in the absorption pathway of buccal or sublingual substances?

    <p>It transports the substances to the heart for distribution throughout the body.</p> Signup and view all the answers

    What is the pH range of saliva that influences the ionization of weak acid or weak base drugs?

    <p>5.6-7.6</p> Signup and view all the answers

    What type of drugs can't go through the lipid membrane of the mouth for absorption?

    <p>Highly ionized drugs</p> Signup and view all the answers

    What is the main reason for using the Henderson-Hasselbalch equation in drug absorption?

    <p>To calculate the proportion of ionized drug based on the pH and pKa of the drug</p> Signup and view all the answers

    What is the main formulation consideration for sublingual tablets?

    <p>Rapid disintegration and dissolution</p> Signup and view all the answers

    What is the impact of nitroglycerin's low melting point and high vapor pressure on its stability?

    <p>Potential loss of content uniformity and potency</p> Signup and view all the answers

    What is the main reason for avoiding excess saliva production with buccal tablets?

    <p>To prevent rapid disintegration and absorption</p> Signup and view all the answers

    What is the purpose of using layers in the formulation of certain tablets?

    <p>To separate incompatible ingredients and provide immediate or sustained release</p> Signup and view all the answers

    What is the main reason for using mucoadhesive properties in certain tablets?

    <p>To keep the tablet at the administration site</p> Signup and view all the answers

    What is the primary reason for avoiding rapid disintegration in buccal tablets?

    <p>To ensure gradual dissolution and absorption</p> Signup and view all the answers

    What is the main reason for using effervescent tablets?

    <p>To dissolve in water for administration</p> Signup and view all the answers

    What is the primary consideration for chewable tablets?

    <p>Good taste and sweetness</p> Signup and view all the answers

    What type of drug release is desired for drugs that are metabolized or not absorbed in the gastrointestinal tract?

    <p>0-order release</p> Signup and view all the answers

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