Absorption Pathway Quiz

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What is the absorption pathway for substances administered sublingually or buccally?

They are absorbed through the small intestine and then enter the portal vein.

They are absorbed directly through the mucous membranes in the mouth and then enter the jugular vein. (correct)

They are absorbed in the stomach and then enter the inferior vena cava.

They are absorbed in the liver and then enter the arterial circulation.

What happens to the tablet's contents after entering the portal vein?

They are absorbed directly into the bloodstream.

They are transported to the heart for distribution throughout the body.

They are pumped into the arterial circulation.

They are transported to the liver for processing and metabolism. (correct)

How do oral tablets enter the arterial circulation to disperse throughout the body?

After reaching the heart, they are pumped into the arterial circulation. (correct)

They bypass the heart and directly enter the arterial circulation from the liver.

They enter the arterial circulation through the inferior vena cava.

They are absorbed into the arterial circulation in the lungs.

What is the role of the inferior vena cava in the absorption pathway of buccal or sublingual substances?

It transports the substances to the heart for distribution throughout the body. Signup and view all the answers

What is the pH range of saliva that influences the ionization of weak acid or weak base drugs?

5.6-7.6 Signup and view all the answers

What type of drugs can't go through the lipid membrane of the mouth for absorption?

Highly ionized drugs Signup and view all the answers

What is the main reason for using the Henderson-Hasselbalch equation in drug absorption?

To calculate the proportion of ionized drug based on the pH and pKa of the drug Signup and view all the answers

What is the main formulation consideration for sublingual tablets?

Rapid disintegration and dissolution Signup and view all the answers

What is the impact of nitroglycerin's low melting point and high vapor pressure on its stability?

Potential loss of content uniformity and potency Signup and view all the answers

What is the main reason for avoiding excess saliva production with buccal tablets?

To prevent rapid disintegration and absorption Signup and view all the answers

What is the purpose of using layers in the formulation of certain tablets?

To separate incompatible ingredients and provide immediate or sustained release Signup and view all the answers

What is the main reason for using mucoadhesive properties in certain tablets?

To keep the tablet at the administration site Signup and view all the answers

What is the primary reason for avoiding rapid disintegration in buccal tablets?

To ensure gradual dissolution and absorption Signup and view all the answers

What is the main reason for using effervescent tablets?

To dissolve in water for administration Signup and view all the answers

What is the primary consideration for chewable tablets?

Good taste and sweetness Signup and view all the answers

What type of drug release is desired for drugs that are metabolized or not absorbed in the gastrointestinal tract?

0-order release Signup and view all the answers

Absorption Pathway Quiz

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Questions and Answers

What is the absorption pathway for substances administered sublingually or buccally?

What happens to the tablet's contents after entering the portal vein?

How do oral tablets enter the arterial circulation to disperse throughout the body?

What is the role of the inferior vena cava in the absorption pathway of buccal or sublingual substances?

What is the pH range of saliva that influences the ionization of weak acid or weak base drugs?

What type of drugs can't go through the lipid membrane of the mouth for absorption?

What is the main reason for using the Henderson-Hasselbalch equation in drug absorption?

What is the main formulation consideration for sublingual tablets?

What is the impact of nitroglycerin's low melting point and high vapor pressure on its stability?

What is the main reason for avoiding excess saliva production with buccal tablets?

What is the purpose of using layers in the formulation of certain tablets?

What is the main reason for using mucoadhesive properties in certain tablets?

What is the primary reason for avoiding rapid disintegration in buccal tablets?

What is the main reason for using effervescent tablets?

What is the primary consideration for chewable tablets?

What type of drug release is desired for drugs that are metabolized or not absorbed in the gastrointestinal tract?

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