Absorption of Drugs Quiz

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Questions and Answers

Which protein is the main drug binding protein in plasma?

  • Hemoglobin
  • Albumin (correct)
  • Globulin
  • Fibrinogen

Which of the following factors related to the drug affects absorption the most?

  • Valency
  • Solubility (correct)
  • Ionization
  • Form

Which organ is the main site for excretion?

  • Gastrointestinal tract
  • Lungs
  • Kidney (correct)
  • Skin glands

Which type of drugs can pass through the blood-brain barrier?

<p>Lipid-soluble, less-ionized drugs (B)</p> Signup and view all the answers

Which of the following factors affects oral absorption of drugs the least?

<p>State of systemic circulation (A)</p> Signup and view all the answers

What effect does alkalinization of urine have on the excretion of acidic drugs?

<p>It increases excretion (A)</p> Signup and view all the answers

Which of the following drinks increases absorption of other drugs?

<p>Tea (B)</p> Signup and view all the answers

What is plasma half-life?

<p>The time needed for the body to decrease the drug concentration to its half (B)</p> Signup and view all the answers

Which phase of metabolism includes conjugation with glucuronic acid?

<p>Phase II (B)</p> Signup and view all the answers

Flashcards

Main plasma drug-binding protein

Albumin is the primary protein in blood plasma that binds to drugs.

Factor most affecting drug absorption

Drug solubility significantly impacts how quickly and efficiently a drug is absorbed.

Main excretion organ

The kidney is the primary organ responsible for eliminating drugs from the body.

BBB-passing drug type

Lipid-soluble and less-ionized drugs can easily cross the blood-brain barrier.

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Factor least affecting oral absorption?

The state of systemic circulation (blood flow) has the weakest effect on oral drug absorption.

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Urine alkalinization impact on acidic drugs

Making urine more alkaline increases the excretion of acidic drugs.

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Drink enhancing drug absorption

Tea can sometimes increase the absorption of other drugs, although more studies are needed.

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Plasma half-life

The time it takes for half the drug concentration in the bloodstream to decrease.

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Phase II metabolism example

Conjugation processes (like with glucuronic acid) are part of phase II metabolism.

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