Abilify Flashcards

Questions and Answers

What is the generic name for Abilify?

Aripiprazole

What class of drug is Abilify?

antipsychotic

Which of the following are dosage forms of Abilify? (Select all that apply)

Capsules: 10, 15, 20 mg

Injection: 9.75 mg/1.3 mL in a single dose vial (correct)

Tabs: 2, 5, 10, 15, 20, 30 mg (correct)

Oral solution: 1 mg/mL (correct)

What is the recommended starting dose of Abilify?

10-15 mg once a day without regard to meals Signup and view all the answers

What are some indications for the use of Abilify? (Select all that apply)

Acute manic episode associated with bipolar disorder Signup and view all the answers

Dosage adjustments in patients taking CYP3A4 inhibitors mean the dosage should be increased.

False Signup and view all the answers

What should be done with the dosage of Abilify when a patient is taking CYP3A4 inducers?

The dosage should be doubled. Signup and view all the answers

What is known about the mechanism of action of Abilify?

Unknown, may involve partial agonist activity at dopamine D2 and serotonin 5-HT1A receptors and antagonist activity at 5-HT2A receptors Signup and view all the answers

How is Abilify metabolized following oral administration?

Metabolized by CYP3A4 and CYP2D6 enzymes to dehydro-aripiprazole Signup and view all the answers

What percentage of the parent drug exposure in plasma does dehydro-aripipazole represent?

40% Signup and view all the answers

What is the half-life of aripiprazole?

75 hours Signup and view all the answers

How many days does it take for Abilify to reach steady state levels?

14 days Signup and view all the answers

Which of the following accurately describes drug interactions with Abilify? (Select all that apply)

CYP3A4 inhibitors may increase plasma levels Signup and view all the answers

What is a key contraindication for using Abilify?

Do not use in patients with dementia-related psychosis Signup and view all the answers

Which of the following are common adverse effects of Abilify? (Select all that apply)

Weight gain Signup and view all the answers

What precautions should be taken when consulting patients using Abilify? (Select all that apply)

Store tabs in a cool, dry place Signup and view all the answers

Study Notes

Abilify Overview

Generic Name: Aripiprazole
Drug Class: Antipsychotic

Dosage Forms

Available in tablet forms: 2, 5, 10, 15, 20, and 30 mg
Orally-disintegrating tablets: 10 and 15 mg
Oral solution: 1 mg/mL
Injection: 9.75 mg/1.3 mL in single dose vial

Recommended Dosage

Starting dose: 10-15 mg once daily, taken independently of meals

Indications

Treats schizophrenia
Addresses acute manic and mixed episodes associated with bipolar disorder

Dosage Adjustments

CYP3A4 or CYP2D6 Inhibitors: Reduce dose to 50% of usual
CYP3A4 Inducers: Double the dose (20 or 30 mg may be used)

Mechanism of Action

Not fully understood
Possible actions include partial agonist effects on dopamine D2 and serotonin 5-HT1A receptors and antagonist effects on 5-HT2A receptors

Metabolism

Metabolized by CYP3A4 and CYP2D6 enzymes into dehydro-aripipazole
Dehydro-aripipazole: Accounts for 40% of the parent drug exposure in plasma

Half-life

Aripiprazole: 75 hours
Dehydro-aripiprazole: 94 hours

Steady State Levels

Reached after approximately 14 days of consistent dosing

Drug Interactions

CYP3A4 Inducers (e.g., carbamazepine): May lower plasma levels of aripiprazole
CYP3A4 Inhibitors: Quinidine, fluoxetine, and paroxetine may increase plasma levels

Contraindications and Precautions

Not recommended for dementia-related psychosis
Risk of neuroleptic malignant syndrome (NMS)
Use with caution in patients with cardiovascular disease, seizures, pneumonia, or elevated body temperatures
Potential for suicidal thoughts
May lead to leukopenia/neutropenia or agranulocytosis
Caution advised for nursing mothers
Classified as pregnancy category C

Adverse Effects

Common: Headache, anxiety, insomnia, asthenia, nausea, vomiting, constipation, weight gain, lightheadedness, drowsiness, blurred vision
Rare: Tardive dyskinesia

Patient Consultation Guidelines

Advise caution with tasks requiring alertness
Recommend avoidance of alcohol
Suggest avoiding extreme heat and dehydration
Store tablets in a cool, dry place; oral solution should be refrigerated
Instruct to contact a physician for prolonged side effects
If a dose is missed, skip it and resume regular schedule

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Description

Test your knowledge about Abilify with these flashcards. This quiz covers essential information including its generic name, drug class, dosage forms, and recommended starting dose. Perfect for students in pharmacology or anyone interested in psychiatric medications.