Podcast
Questions and Answers
What is the generic name for Abilify?
What is the generic name for Abilify?
Aripiprazole
What class of drug is Abilify?
What class of drug is Abilify?
antipsychotic
Which of the following are dosage forms of Abilify? (Select all that apply)
Which of the following are dosage forms of Abilify? (Select all that apply)
- Capsules: 10, 15, 20 mg
- Injection: 9.75 mg/1.3 mL in a single dose vial (correct)
- Tabs: 2, 5, 10, 15, 20, 30 mg (correct)
- Oral solution: 1 mg/mL (correct)
What is the recommended starting dose of Abilify?
What is the recommended starting dose of Abilify?
What are some indications for the use of Abilify? (Select all that apply)
What are some indications for the use of Abilify? (Select all that apply)
Dosage adjustments in patients taking CYP3A4 inhibitors mean the dosage should be increased.
Dosage adjustments in patients taking CYP3A4 inhibitors mean the dosage should be increased.
What should be done with the dosage of Abilify when a patient is taking CYP3A4 inducers?
What should be done with the dosage of Abilify when a patient is taking CYP3A4 inducers?
What is known about the mechanism of action of Abilify?
What is known about the mechanism of action of Abilify?
How is Abilify metabolized following oral administration?
How is Abilify metabolized following oral administration?
What percentage of the parent drug exposure in plasma does dehydro-aripipazole represent?
What percentage of the parent drug exposure in plasma does dehydro-aripipazole represent?
What is the half-life of aripiprazole?
What is the half-life of aripiprazole?
How many days does it take for Abilify to reach steady state levels?
How many days does it take for Abilify to reach steady state levels?
Which of the following accurately describes drug interactions with Abilify? (Select all that apply)
Which of the following accurately describes drug interactions with Abilify? (Select all that apply)
What is a key contraindication for using Abilify?
What is a key contraindication for using Abilify?
Which of the following are common adverse effects of Abilify? (Select all that apply)
Which of the following are common adverse effects of Abilify? (Select all that apply)
What precautions should be taken when consulting patients using Abilify? (Select all that apply)
What precautions should be taken when consulting patients using Abilify? (Select all that apply)
Study Notes
Abilify Overview
- Generic Name: Aripiprazole
- Drug Class: Antipsychotic
Dosage Forms
- Available in tablet forms: 2, 5, 10, 15, 20, and 30 mg
- Orally-disintegrating tablets: 10 and 15 mg
- Oral solution: 1 mg/mL
- Injection: 9.75 mg/1.3 mL in single dose vial
Recommended Dosage
- Starting dose: 10-15 mg once daily, taken independently of meals
Indications
- Treats schizophrenia
- Addresses acute manic and mixed episodes associated with bipolar disorder
Dosage Adjustments
- CYP3A4 or CYP2D6 Inhibitors: Reduce dose to 50% of usual
- CYP3A4 Inducers: Double the dose (20 or 30 mg may be used)
Mechanism of Action
- Not fully understood
- Possible actions include partial agonist effects on dopamine D2 and serotonin 5-HT1A receptors and antagonist effects on 5-HT2A receptors
Metabolism
- Metabolized by CYP3A4 and CYP2D6 enzymes into dehydro-aripipazole
- Dehydro-aripipazole: Accounts for 40% of the parent drug exposure in plasma
Half-life
- Aripiprazole: 75 hours
- Dehydro-aripiprazole: 94 hours
Steady State Levels
- Reached after approximately 14 days of consistent dosing
Drug Interactions
- CYP3A4 Inducers (e.g., carbamazepine): May lower plasma levels of aripiprazole
- CYP3A4 Inhibitors: Quinidine, fluoxetine, and paroxetine may increase plasma levels
Contraindications and Precautions
- Not recommended for dementia-related psychosis
- Risk of neuroleptic malignant syndrome (NMS)
- Use with caution in patients with cardiovascular disease, seizures, pneumonia, or elevated body temperatures
- Potential for suicidal thoughts
- May lead to leukopenia/neutropenia or agranulocytosis
- Caution advised for nursing mothers
- Classified as pregnancy category C
Adverse Effects
- Common: Headache, anxiety, insomnia, asthenia, nausea, vomiting, constipation, weight gain, lightheadedness, drowsiness, blurred vision
- Rare: Tardive dyskinesia
Patient Consultation Guidelines
- Advise caution with tasks requiring alertness
- Recommend avoidance of alcohol
- Suggest avoiding extreme heat and dehydration
- Store tablets in a cool, dry place; oral solution should be refrigerated
- Instruct to contact a physician for prolonged side effects
- If a dose is missed, skip it and resume regular schedule
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Description
Test your knowledge about Abilify with these flashcards. This quiz covers essential information including its generic name, drug class, dosage forms, and recommended starting dose. Perfect for students in pharmacology or anyone interested in psychiatric medications.
