Abilify Flashcards
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Questions and Answers

What is the generic name for Abilify?

Aripiprazole

What class of drug is Abilify?

antipsychotic

Which of the following are dosage forms of Abilify? (Select all that apply)

  • Capsules: 10, 15, 20 mg
  • Injection: 9.75 mg/1.3 mL in a single dose vial (correct)
  • Tabs: 2, 5, 10, 15, 20, 30 mg (correct)
  • Oral solution: 1 mg/mL (correct)
  • What is the recommended starting dose of Abilify?

    <p>10-15 mg once a day without regard to meals</p> Signup and view all the answers

    What are some indications for the use of Abilify? (Select all that apply)

    <p>Acute manic episode associated with bipolar disorder</p> Signup and view all the answers

    Dosage adjustments in patients taking CYP3A4 inhibitors mean the dosage should be increased.

    <p>False</p> Signup and view all the answers

    What should be done with the dosage of Abilify when a patient is taking CYP3A4 inducers?

    <p>The dosage should be doubled.</p> Signup and view all the answers

    What is known about the mechanism of action of Abilify?

    <p>Unknown, may involve partial agonist activity at dopamine D2 and serotonin 5-HT1A receptors and antagonist activity at 5-HT2A receptors</p> Signup and view all the answers

    How is Abilify metabolized following oral administration?

    <p>Metabolized by CYP3A4 and CYP2D6 enzymes to dehydro-aripiprazole</p> Signup and view all the answers

    What percentage of the parent drug exposure in plasma does dehydro-aripipazole represent?

    <p>40%</p> Signup and view all the answers

    What is the half-life of aripiprazole?

    <p>75 hours</p> Signup and view all the answers

    How many days does it take for Abilify to reach steady state levels?

    <p>14 days</p> Signup and view all the answers

    Which of the following accurately describes drug interactions with Abilify? (Select all that apply)

    <p>CYP3A4 inhibitors may increase plasma levels</p> Signup and view all the answers

    What is a key contraindication for using Abilify?

    <p>Do not use in patients with dementia-related psychosis</p> Signup and view all the answers

    Which of the following are common adverse effects of Abilify? (Select all that apply)

    <p>Weight gain</p> Signup and view all the answers

    What precautions should be taken when consulting patients using Abilify? (Select all that apply)

    <p>Store tabs in a cool, dry place</p> Signup and view all the answers

    Study Notes

    Abilify Overview

    • Generic Name: Aripiprazole
    • Drug Class: Antipsychotic

    Dosage Forms

    • Available in tablet forms: 2, 5, 10, 15, 20, and 30 mg
    • Orally-disintegrating tablets: 10 and 15 mg
    • Oral solution: 1 mg/mL
    • Injection: 9.75 mg/1.3 mL in single dose vial
    • Starting dose: 10-15 mg once daily, taken independently of meals

    Indications

    • Treats schizophrenia
    • Addresses acute manic and mixed episodes associated with bipolar disorder

    Dosage Adjustments

    • CYP3A4 or CYP2D6 Inhibitors: Reduce dose to 50% of usual
    • CYP3A4 Inducers: Double the dose (20 or 30 mg may be used)

    Mechanism of Action

    • Not fully understood
    • Possible actions include partial agonist effects on dopamine D2 and serotonin 5-HT1A receptors and antagonist effects on 5-HT2A receptors

    Metabolism

    • Metabolized by CYP3A4 and CYP2D6 enzymes into dehydro-aripipazole
    • Dehydro-aripipazole: Accounts for 40% of the parent drug exposure in plasma

    Half-life

    • Aripiprazole: 75 hours
    • Dehydro-aripiprazole: 94 hours

    Steady State Levels

    • Reached after approximately 14 days of consistent dosing

    Drug Interactions

    • CYP3A4 Inducers (e.g., carbamazepine): May lower plasma levels of aripiprazole
    • CYP3A4 Inhibitors: Quinidine, fluoxetine, and paroxetine may increase plasma levels

    Contraindications and Precautions

    • Not recommended for dementia-related psychosis
    • Risk of neuroleptic malignant syndrome (NMS)
    • Use with caution in patients with cardiovascular disease, seizures, pneumonia, or elevated body temperatures
    • Potential for suicidal thoughts
    • May lead to leukopenia/neutropenia or agranulocytosis
    • Caution advised for nursing mothers
    • Classified as pregnancy category C

    Adverse Effects

    • Common: Headache, anxiety, insomnia, asthenia, nausea, vomiting, constipation, weight gain, lightheadedness, drowsiness, blurred vision
    • Rare: Tardive dyskinesia

    Patient Consultation Guidelines

    • Advise caution with tasks requiring alertness
    • Recommend avoidance of alcohol
    • Suggest avoiding extreme heat and dehydration
    • Store tablets in a cool, dry place; oral solution should be refrigerated
    • Instruct to contact a physician for prolonged side effects
    • If a dose is missed, skip it and resume regular schedule

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    Description

    Test your knowledge about Abilify with these flashcards. This quiz covers essential information including its generic name, drug class, dosage forms, and recommended starting dose. Perfect for students in pharmacology or anyone interested in psychiatric medications.

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