Abelmoschus esculentus Hypolipidemic Effect Quiz

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What is the primary objective of the study?

To compare the effect of Abelmoschus esculentus with other herbal remedies

To investigate the hypolipidemic activity of Abelmoschus esculentus extracts (correct)

To examine the toxicity of Abelmoschus esculentus in mice

To study the effect of Abelmoschus esculentus on body weight

How was hyperlipidemia induced in mice?

By feeding mice with alloxan-rich food

By injecting tyloxapol via intraperitoneal route (correct)

By administering streptozocin via intravenous route

By orally administering a high-fat diet

What was the dose of extracts administered to the mice?

Equivalent to 30 g of dry extract per kg (correct)

Equivalent to 100 g of dry extract per kg

Equivalent to 50 g of dry extract per kg

Equivalent to 10 g of dry extract per kg

What was the percentage decrease in cholesterol levels in the group administered with AE1?

56.45% Signup and view all the answers

What was used as a control group in this study?

Mice injected with tyloxapol only Signup and view all the answers

How many extracts were studied in this research?

4 Signup and view all the answers

Where were the fresh fruits and total plants of Abelmoschus esculentus L. collected from?

Local market in Long An province, Vietnam Signup and view all the answers

What was used to extract the plant materials in a Soxhlet?

Methanol and dichloromethane Signup and view all the answers

What was the purpose of depriving the mice of food in the night before the experiment?

To ensure uniform experimental conditions Signup and view all the answers

What was the role of simvastatin (Zocor®) in the experiment?

As a treatment for hyperlipidemia Signup and view all the answers

How many groups were the mice divided into for the experiment?

Seven groups of eight mice each Signup and view all the answers

What was the average weight of the mice used in the experiment?

20 ± 2 g Signup and view all the answers

What was the purpose of this study?

To investigate the hypolipidemic effect of extracts from A. esculentus Signup and view all the answers

What was the result of comparing the reduction in cholesterol levels among the four extract treated groups?

There was no significant difference among the groups Signup and view all the answers

Which extract had the least hypotriglyceridemic activity?

AE4 Signup and view all the answers

What was the time period after administration when the plasma cholesterol and triglyceride levels were measured?

24 hours Signup and view all the answers

What was the effect of AE1, AE2, and AE3 on triglyceride levels compared to simvastatin?

Comparable to simvastatin Signup and view all the answers

What was the substance used to induce hyperlipidemia in mice?

Tyloxapol Signup and view all the answers

What is the potential application of A.esculentus extracts according to the study?

Prevention and treatment of hyperlipidemia Signup and view all the answers

What is the purpose of further studies in other animal species and hyperlipidemic models?

To elucidate the hypolipidemic activity of the extracts Signup and view all the answers

What is the role of myricetin in the study?

It is the active principle of Abelmoschus moschatus to lower plasma glucose Signup and view all the answers

What is the significance of the study by Kahlon et al.?

It showed the binding of bile acids by okra, beets, asparagus, eggplant, turnips, green beans, carrots, and cauliflower Signup and view all the answers

What is the purpose of inducing hyperlipidemia in animals like rats?

To develop a model for screening hyperlipidemic drugs Signup and view all the answers

What is the significance of the study by Kourounakis et al.?

It showed the effect of NSAIDs on experimental hyperlipidemia Signup and view all the answers

What was the purpose of injecting tyloxapol solution into the mice?

To induce hyperlipidemia Signup and view all the answers

What was the dose of simvastatin administered to Group III mice?

80 mg/kg, once per day Signup and view all the answers

What was the route of administration for the extracts in Groups IV, V, VI, and VII?

Oral administration Signup and view all the answers

How were the total cholesterol and triglyceride levels analyzed in the serum?

By using the enzymatic-colorimetric method Signup and view all the answers

What statistical test was used to evaluate the data?

Kruskal-Wallis test and Mann-Withney test Signup and view all the answers

What was the significance level used to determine statistical significance?

p < 0.05 Signup and view all the answers