Abelmoschus esculentus Hypolipidemic Effect Quiz

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Questions and Answers

What is the primary objective of the study?

  • To compare the effect of Abelmoschus esculentus with other herbal remedies
  • To investigate the hypolipidemic activity of Abelmoschus esculentus extracts (correct)
  • To examine the toxicity of Abelmoschus esculentus in mice
  • To study the effect of Abelmoschus esculentus on body weight

How was hyperlipidemia induced in mice?

  • By feeding mice with alloxan-rich food
  • By injecting tyloxapol via intraperitoneal route (correct)
  • By administering streptozocin via intravenous route
  • By orally administering a high-fat diet

What was the dose of extracts administered to the mice?

  • Equivalent to 30 g of dry extract per kg (correct)
  • Equivalent to 100 g of dry extract per kg
  • Equivalent to 50 g of dry extract per kg
  • Equivalent to 10 g of dry extract per kg

What was the percentage decrease in cholesterol levels in the group administered with AE1?

<p>56.45% (C)</p> Signup and view all the answers

What was used as a control group in this study?

<p>Mice injected with tyloxapol only (A)</p> Signup and view all the answers

How many extracts were studied in this research?

<p>4 (A)</p> Signup and view all the answers

Where were the fresh fruits and total plants of Abelmoschus esculentus L. collected from?

<p>Local market in Long An province, Vietnam (D)</p> Signup and view all the answers

What was used to extract the plant materials in a Soxhlet?

<p>Methanol and dichloromethane (D)</p> Signup and view all the answers

What was the purpose of depriving the mice of food in the night before the experiment?

<p>To ensure uniform experimental conditions (A)</p> Signup and view all the answers

What was the role of simvastatin (Zocor®) in the experiment?

<p>As a treatment for hyperlipidemia (A)</p> Signup and view all the answers

How many groups were the mice divided into for the experiment?

<p>Seven groups of eight mice each (A)</p> Signup and view all the answers

What was the average weight of the mice used in the experiment?

<p>20 ± 2 g (A)</p> Signup and view all the answers

What was the purpose of this study?

<p>To investigate the hypolipidemic effect of extracts from A. esculentus (B)</p> Signup and view all the answers

What was the result of comparing the reduction in cholesterol levels among the four extract treated groups?

<p>There was no significant difference among the groups (B)</p> Signup and view all the answers

Which extract had the least hypotriglyceridemic activity?

<p>AE4 (A)</p> Signup and view all the answers

What was the time period after administration when the plasma cholesterol and triglyceride levels were measured?

<p>24 hours (A)</p> Signup and view all the answers

What was the effect of AE1, AE2, and AE3 on triglyceride levels compared to simvastatin?

<p>Comparable to simvastatin (A)</p> Signup and view all the answers

What was the substance used to induce hyperlipidemia in mice?

<p>Tyloxapol (C)</p> Signup and view all the answers

What is the potential application of A.esculentus extracts according to the study?

<p>Prevention and treatment of hyperlipidemia (D)</p> Signup and view all the answers

What is the purpose of further studies in other animal species and hyperlipidemic models?

<p>To elucidate the hypolipidemic activity of the extracts (C)</p> Signup and view all the answers

What is the role of myricetin in the study?

<p>It is the active principle of Abelmoschus moschatus to lower plasma glucose (D)</p> Signup and view all the answers

What is the significance of the study by Kahlon et al.?

<p>It showed the binding of bile acids by okra, beets, asparagus, eggplant, turnips, green beans, carrots, and cauliflower (D)</p> Signup and view all the answers

What is the purpose of inducing hyperlipidemia in animals like rats?

<p>To develop a model for screening hyperlipidemic drugs (B)</p> Signup and view all the answers

What is the significance of the study by Kourounakis et al.?

<p>It showed the effect of NSAIDs on experimental hyperlipidemia (C)</p> Signup and view all the answers

What was the purpose of injecting tyloxapol solution into the mice?

<p>To induce hyperlipidemia (A)</p> Signup and view all the answers

What was the dose of simvastatin administered to Group III mice?

<p>80 mg/kg, once per day (B)</p> Signup and view all the answers

What was the route of administration for the extracts in Groups IV, V, VI, and VII?

<p>Oral administration (A)</p> Signup and view all the answers

How were the total cholesterol and triglyceride levels analyzed in the serum?

<p>By using the enzymatic-colorimetric method (D)</p> Signup and view all the answers

What statistical test was used to evaluate the data?

<p>Kruskal-Wallis test and Mann-Withney test (C)</p> Signup and view all the answers

What was the significance level used to determine statistical significance?

<p>p &lt; 0.05 (D)</p> Signup and view all the answers

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