Abacavir

Abacavir is a nucleoside reverse transcriptase inhibitor used in combination with other anti-retroviral medications indicated for the treatment of HIV. Abacavir is generally well-tolerated by patients, however, in 5–8 % of individuals undergoing treatment, a hypersensitivity reaction occurs (Martin et al. 2012). Symptoms of hypersensitivity include fever, rash, fatigue, cough, gastrointestinal symptoms, and dyspnea (shortness of breath). A genetic variant in HLA-B, HLA-B57:01, is associated with this hypersensitivity reaction in about 6 % of patients (Martin et al. 2012). This association has been reviewed by Martin et al. (2012). Not only was this association observed in retrospective analyses of clinical trials, there was also a prospective, double-blind, randomized clinical trial of a genetic test to reduce adverse events through screening for HLA-B57:01 before treatment (PREDICT-1) (Mallal et al. 2008). Based on the results of this trial and other supporting evidence, th.

Abacavir is a nucleoside reverse transcriptase inhibitor used in combination with other anti-retroviral medications indicated for the treatment of HIV. Abacavir is generally well-tolerated by patients, however, in 5–8 % of individuals undergoing treatment, a hypersensitivity reaction occurs (Martin et al. 2012). Symptoms of hypersensitivity include fever, rash, fatigue, cough, gastrointestinal symptoms, and dyspnea (shortness of breath). A genetic variant in HLA-B, HLA-B57:01, is associated with this hypersensitivity reaction in about 6 % of patients (Martin et al. 2012). This association has been reviewed by Martin et al. (2012). Not only was this association observed in retrospective analyses of clinical trials, there was also a prospective, double-blind, randomized clinical trial of a genetic test to reduce adverse events through screening for HLA-B57:01 before treatment (PREDICT-1) (Mallal et al. 2008). Based on the results of this trial and other supporting evidence, th.

Abacavir is generally well-tolerated by patients, however, in 5–8 % of individuals undergoing treatment, a hypersensitivity reaction occurs.

Abacavir is generally well-tolerated by patients, however, in 5–8 % of individuals undergoing treatment, a hypersensitivity reaction occurs.

Symptoms of hypersensitivity include fever, rash, fatigue, cough, gastrointestinal symptoms, and dyspnea (shortness of breath).

Symptoms of hypersensitivity include fever, rash, fatigue, cough, gastrointestinal symptoms, and dyspnea (shortness of breath).

A genetic variant in HLA-B, HLA-B*57:01, is associated with this hypersensitivity reaction in about 6 % of patients (Martin et al. 2012). This association has been reviewed by Martin et al. (2012).

A genetic variant in HLA-B, HLA-B*57:01, is associated with this hypersensitivity reaction in about 6 % of patients (Martin et al. 2012). This association has been reviewed by Martin et al. (2012).

Not only was this association observed in retrospective analyses of clinical trials, there was also a prospective, double-blind, randomized clinical trial of a genetic test to reduce adverse events through screening for HLA-B*57:01 before treatment (PREDICT-1) (Mallal et al. 2008). Based on the results of this trial and other supporting evidence, th.

Not only was this association observed in retrospective analyses of clinical trials, there was also a prospective, double-blind, randomized clinical trial of a genetic test to reduce adverse events through screening for HLA-B*57:01 before treatment (PREDICT-1) (Mallal et al. 2008). Based on the results of this trial and other supporting evidence, th.

5-8%

Fever, rash, and fatigue

HLA-B*57:01

Through a retrospective analysis of clinical trials

To reduce adverse events through screening for HLA-B*57:01 before treatment