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Questions and Answers

Describe the regulation of pituitary hormones.

Which of the following is a circulating form of thyroid hormone?

  • T4-TBPA
  • TGL-T3
  • T3-TBPA (correct)
  • TGL-T4

What percentage of T4 and T3 are bound to transport proteins?

  • 7%
  • 1-7%
  • Less than 1%
  • 28% (correct)

What is the main reason for requiring highly sensitive TSH assays?

<p>To accurately measure TSH levels in disequilibrium states (A)</p> Signup and view all the answers

Which of the following is true about T4 and T3 hormone levels?

<p>All of the above (D)</p> Signup and view all the answers

What is the range for plasma T4 levels?

<p>60-140nM (D)</p> Signup and view all the answers

Which of the following is NOT a physiological effect of thyroid hormones?

<p>Lowers plasma cholesterol (C)</p> Signup and view all the answers

What is the worldwide incidence of cretinism caused by thyroid hormone deficiency?

<p>1/10000 (B)</p> Signup and view all the answers

Which solution is added to trigger the light emission in the Roche chemiluminescent fT4 assay?

<p>NaOH (D)</p> Signup and view all the answers

What is the purpose of adding TPA and voltage in the Roche chemiluminescent fT4 assay?

<p>To stimulate chemiluminescence (B)</p> Signup and view all the answers

What is the possible interference in the Roche fT4 assay when there is a high dose of biotin?

<p>Streptavidin antibodies (C)</p> Signup and view all the answers

Which drugs can decrease Thyroid Binding Globulin (TBG) levels?

<p>Tranquilizers (A)</p> Signup and view all the answers

Which of the following is a symptom of thyroid storm?

<p>High pulse rate (A)</p> Signup and view all the answers

What is the medical emergency associated with hypothyroidism?

<p>Myxoedema coma (B)</p> Signup and view all the answers

Which laboratory tests are used for the diagnosis of thyroid diseases?

<p>Measurement of serum thyroid hormone levels (T4 and T3) (B)</p> Signup and view all the answers

What is the most likely diagnosis for a patient with a TSH level of 40 mU/L and fT4 level of 5 pmol/L?

<p>Hypothyroidism (B)</p> Signup and view all the answers

Based on the data provided, what is the average TSH concentration in mU/L?

<p>1.12 (A)</p> Signup and view all the answers

What is the standard deviation of the TSH concentrations in mU/L?

<p>0.34 (D)</p> Signup and view all the answers

What is the coefficient of variation (CV) of the TSH concentrations in percentage?

<p>5.19% (A)</p> Signup and view all the answers

What is the functional sensitivity of the TSH assay?

<p>0.29 mU/L (C)</p> Signup and view all the answers

Which term describes a thyroid function that is normal?

<p>Euthyroid (D)</p> Signup and view all the answers

Which term describes a thyroid function that is not normal, but the tests indicate otherwise?

<p>Sick Euthyroid (A)</p> Signup and view all the answers

Which term describes a thyroid function that is not normal and is characterized by increased BMR, tachycardia, heat intolerance, and weight loss?

<p>Hyperthyroidism (D)</p> Signup and view all the answers

Which term describes a thyroid function that is not normal and is characterized by decreased BMR, bradycardia, cold intolerance, and weight gain?

<p>Hypothyroidism (D)</p> Signup and view all the answers

Which of the following is a possible effect of subclinical hyperthyroidism in pregnancy?

<p>Possible effects on fetal brain development (B)</p> Signup and view all the answers

Which of the following is a suggested group to screen for subclinical thyroid disease?

<p>Women (D)</p> Signup and view all the answers

Which of the following is a characteristic of primary hyperthyroidism?

<p>High fT4 and normal TSH levels (D)</p> Signup and view all the answers

Which of the following is a consequence of heterophilic antibody interference in Graves disease?

<p>High fT4 and low TSH levels (B)</p> Signup and view all the answers

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