28 Questions
Describe the regulation of pituitary hormones.
Which of the following is a circulating form of thyroid hormone?
T3-TBPA
What percentage of T4 and T3 are bound to transport proteins?
28%
What is the main reason for requiring highly sensitive TSH assays?
To accurately measure TSH levels in disequilibrium states
Which of the following is true about T4 and T3 hormone levels?
All of the above
What is the range for plasma T4 levels?
60-140nM
Which of the following is NOT a physiological effect of thyroid hormones?
Lowers plasma cholesterol
What is the worldwide incidence of cretinism caused by thyroid hormone deficiency?
1/10000
Which solution is added to trigger the light emission in the Roche chemiluminescent fT4 assay?
NaOH
What is the purpose of adding TPA and voltage in the Roche chemiluminescent fT4 assay?
To stimulate chemiluminescence
What is the possible interference in the Roche fT4 assay when there is a high dose of biotin?
Streptavidin antibodies
Which drugs can decrease Thyroid Binding Globulin (TBG) levels?
Tranquilizers
Which of the following is a symptom of thyroid storm?
High pulse rate
What is the medical emergency associated with hypothyroidism?
Myxoedema coma
Which laboratory tests are used for the diagnosis of thyroid diseases?
Measurement of serum thyroid hormone levels (T4 and T3)
What is the most likely diagnosis for a patient with a TSH level of 40 mU/L and fT4 level of 5 pmol/L?
Hypothyroidism
Based on the data provided, what is the average TSH concentration in mU/L?
1.12
What is the standard deviation of the TSH concentrations in mU/L?
0.34
What is the coefficient of variation (CV) of the TSH concentrations in percentage?
5.19%
What is the functional sensitivity of the TSH assay?
0.29 mU/L
Which term describes a thyroid function that is normal?
Euthyroid
Which term describes a thyroid function that is not normal, but the tests indicate otherwise?
Sick Euthyroid
Which term describes a thyroid function that is not normal and is characterized by increased BMR, tachycardia, heat intolerance, and weight loss?
Hyperthyroidism
Which term describes a thyroid function that is not normal and is characterized by decreased BMR, bradycardia, cold intolerance, and weight gain?
Hypothyroidism
Which of the following is a possible effect of subclinical hyperthyroidism in pregnancy?
Possible effects on fetal brain development
Which of the following is a suggested group to screen for subclinical thyroid disease?
Women
Which of the following is a characteristic of primary hyperthyroidism?
High fT4 and normal TSH levels
Which of the following is a consequence of heterophilic antibody interference in Graves disease?
High fT4 and low TSH levels
Test your knowledge of the regulation of pituitary hormones and circulating thyroid hormones. This quiz covers topics such as the binding of T4 and T3 to transport proteins, the need for highly sensitive TSH assays, and the range for plasma T4 levels.
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