Untitled

Play an AI-generated podcast conversation about this lesson

Describe the regulation of pituitary hormones.

Which of the following is a circulating form of thyroid hormone?

T4-TBPA

TGL-T3

T3-TBPA (correct)

TGL-T4

What percentage of T4 and T3 are bound to transport proteins?

7%

1-7%

Less than 1%

28% (correct)

What is the main reason for requiring highly sensitive TSH assays?

To accurately measure TSH levels in disequilibrium states (A) Signup and view all the answers

Which of the following is true about T4 and T3 hormone levels?

All of the above (D) Signup and view all the answers

What is the range for plasma T4 levels?

60-140nM (D) Signup and view all the answers

Which of the following is NOT a physiological effect of thyroid hormones?

Lowers plasma cholesterol (C) Signup and view all the answers

What is the worldwide incidence of cretinism caused by thyroid hormone deficiency?

1/10000 (B) Signup and view all the answers

Which solution is added to trigger the light emission in the Roche chemiluminescent fT4 assay?

NaOH (D) Signup and view all the answers

What is the purpose of adding TPA and voltage in the Roche chemiluminescent fT4 assay?

To stimulate chemiluminescence (B) Signup and view all the answers

What is the possible interference in the Roche fT4 assay when there is a high dose of biotin?

Streptavidin antibodies (C) Signup and view all the answers

Which drugs can decrease Thyroid Binding Globulin (TBG) levels?

Tranquilizers (A) Signup and view all the answers

Which of the following is a symptom of thyroid storm?

High pulse rate (A) Signup and view all the answers

What is the medical emergency associated with hypothyroidism?

Myxoedema coma (B) Signup and view all the answers

Which laboratory tests are used for the diagnosis of thyroid diseases?

Measurement of serum thyroid hormone levels (T4 and T3) (B) Signup and view all the answers

What is the most likely diagnosis for a patient with a TSH level of 40 mU/L and fT4 level of 5 pmol/L?

Hypothyroidism (B) Signup and view all the answers

Based on the data provided, what is the average TSH concentration in mU/L?

1.12 (A) Signup and view all the answers

What is the standard deviation of the TSH concentrations in mU/L?

0.34 (D) Signup and view all the answers

What is the coefficient of variation (CV) of the TSH concentrations in percentage?

5.19% (A) Signup and view all the answers

What is the functional sensitivity of the TSH assay?

0.29 mU/L (C) Signup and view all the answers

Which term describes a thyroid function that is normal?

Euthyroid (D) Signup and view all the answers

Which term describes a thyroid function that is not normal, but the tests indicate otherwise?

Sick Euthyroid (A) Signup and view all the answers

Which term describes a thyroid function that is not normal and is characterized by increased BMR, tachycardia, heat intolerance, and weight loss?

Hyperthyroidism (D) Signup and view all the answers

Which term describes a thyroid function that is not normal and is characterized by decreased BMR, bradycardia, cold intolerance, and weight gain?

Hypothyroidism (D) Signup and view all the answers

Which of the following is a possible effect of subclinical hyperthyroidism in pregnancy?

Possible effects on fetal brain development (B) Signup and view all the answers

Which of the following is a suggested group to screen for subclinical thyroid disease?

Women (D) Signup and view all the answers

Which of the following is a characteristic of primary hyperthyroidism?

High fT4 and normal TSH levels (D) Signup and view all the answers

Which of the following is a consequence of heterophilic antibody interference in Graves disease?

High fT4 and low TSH levels (B) Signup and view all the answers