Module 8
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Questions and Answers

They contain Hemoglobin (Hgb) which carries Oxygen to the different tissues of the body. They also contain enzymes (Carbonic anhydrases) that catalyze the reaction between CO2 and water to become Carbonic acid.

  • White Blood Cells
  • Red Blood Cells (correct)
  • Platelets
  • Monocytes
  • It transports oxygen and other nutrients.

  • Red Blood Cells
  • Blood (correct)
  • White Blood Cells
  • Platelets
  • Generally biconcave discs, non-nucleated, and non-motile.

  • Mammalian (correct)
  • Hemoglobin
  • Hormones
  • Avian
  • Increase in the number of circulating RBC.

    <p>Polycythemia (A)</p> Signup and view all the answers

    Decrease in the number of circulating RBC.

    <p>Anemia (C)</p> Signup and view all the answers

    1 WBC: __ RBC

    <p>7</p> Signup and view all the answers

    The younger the Red Blood Cell, the _____ it is.

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    Listed below are the Hemopoietic Organs except:

    <p>Pancreas (D)</p> Signup and view all the answers

    ___ = embryonic life

    <p>Yolk sac (C)</p> Signup and view all the answers

    Oval, nucleated, and non-motile.

    <p>Avians (A)</p> Signup and view all the answers

    __ = main organ of production during second trimester of gestation (spleen and lymph nodes are also active)

    <p>Liver (A)</p> Signup and view all the answers

    As the RBC mature, it _____ in size.

    <p>Decrease</p> Signup and view all the answers

    Later part of gestation and after the birth of an individual

    <p>Bone marrow (D)</p> Signup and view all the answers

    It is a depression at the center of the red blood cell.

    <p>Central Pallor (B)</p> Signup and view all the answers

    It means blood in general.

    <p>Hemo (D)</p> Signup and view all the answers

    Precursor/origin of all blood cell.

    <p>Pleuripotent Hemopoietic Stem Cell (D)</p> Signup and view all the answers

    It means poiesis, genesis/formation.

    <p>Poietic (B)</p> Signup and view all the answers

    All blood cell in bone marrow later become committed stem cells for formation of RBC, WBC, and _____.

    <p>Megakaryocte</p> Signup and view all the answers

    -Nucleated -Formation of hemoglobin starts here

    <p>Proerythroblast (B)</p> Signup and view all the answers

    Immature RBC, with nucleus

    <p>Reticulocytes (B)</p> Signup and view all the answers

    Mature RBC, no nucleus

    <p>Erythrocytes (A)</p> Signup and view all the answers

    When there is a nucleated RBC in a blood smear, it means there are many _____. It is abnormal, meaning _____ is fastened.

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    It is a large cells, later on divided into fragments (platelet)

    <p>Megakaryocyte (B)</p> Signup and view all the answers

    Needed for formation of hemoglobin.

    <p>Iron (D)</p> Signup and view all the answers

    Formation of red blood cells requires a hormone called:

    <p>Erythropoietin (A)</p> Signup and view all the answers

    It is a substance secreted by the kidney cells/tissues in response to factors that decreases tissue oxygenation such as; low blood volume, anemia, poor blood flow, and any pulmonary disease that hinders intake of air.

    <p>Erythropoietin (C)</p> Signup and view all the answers

    Life span of RBC of Horse

    <p>140-150 days (C)</p> Signup and view all the answers

    Life span of RBC of Dog

    <p>100-130 days (A)</p> Signup and view all the answers

    Life span of RBC of Cat

    <p>70-80 days (D)</p> Signup and view all the answers

    Life span of RBC of Adult ruminants

    <p>125-150 days (A)</p> Signup and view all the answers

    Life span of RBC of Young ruminants

    <p>50-100 days (C)</p> Signup and view all the answers

    Life span of RBC of Pig

    <p>51-79 days (B)</p> Signup and view all the answers

    Requirement for Maturation of RBC.

    <p>Vitamin 12 (Cyanocobalamin) and Folic acid (Pteroylglutamic acid)</p> Signup and view all the answers

    Life span of RBC of Chicken

    <p>20-30 days (C)</p> Signup and view all the answers

    Life span of RBC of Ducks

    <p>30-40 days (B)</p> Signup and view all the answers

    • Marked by having big RBC due to failure in maturation or failure of the cell membrane to fully develop.
    • Have fragile membrane upon diapedesis, they can rupture.

    <p>Megaloblastic Anemia (C)</p> Signup and view all the answers

    Listed below are the Types of Anemia except:

    <p>Micryocytic Hypochromic Anemia and Megaloblastic Anemia (D)</p> Signup and view all the answers

    Mycrocytic = small RBC formed Hypochromic = deficiency in iron RBCs do not last

    <p>Mycrocytic Hypochromic Anemia (B)</p> Signup and view all the answers

    It is due to incompatible blood type between maternal and fetal blood groups.

    <p>Erythroblastosis Fetalis (A)</p> Signup and view all the answers

    • Many sickle cell RBCs are formed due to abnormality in formation of hemoglobin.
    • Sensitive to low oxygen (hypoxia), may crystalize and form a spiny end that can puncture the membrane of RBC causing hemolysis/rupture.

    <p>Sickle Cell Anemia (D)</p> Signup and view all the answers

    • Globulin formation
    • Counterpart of proerythroblast, starts the formation of hemoglobin

    <p>Rubriblast (D)</p> Signup and view all the answers

    Immature RBC

    <p>Basophilic erythrocyte (A)</p> Signup and view all the answers

    Increase in reticulocytes

    <p>Reticulocytosis (B)</p> Signup and view all the answers

    Decrease in tissue oxygenation

    <p>Hypoxia (B)</p> Signup and view all the answers

    A decrease in tissue oxygenation stimulates the _____ to release _____ hormone which triggers erythropoiesis.

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    Erythropoietin is released by the kidney, specifically:

    <p>JG cells (juxtaglomerular) (A)</p> Signup and view all the answers

    Pernicious Anemia is due to:

    <p>Vitamin 12 deficiency (D)</p> Signup and view all the answers

    Other substances needed for formation of RBC are listed below except;

    <p>Calcium (B)</p> Signup and view all the answers

    Are specialized macrophages located in the liver, lining the walls of the sinusoids.

    <p>Kupffer cells (C)</p> Signup and view all the answers

    ______ = human and in some lab animals

    <p>Spleen (B)</p> Signup and view all the answers

    _____ = In most domestic mammals

    <p>Red Bone Marrow (A)</p> Signup and view all the answers

    Composition of MPS (Mononuclear Phagocytic System)

    <p>a. Kupffer cells b. Alveolar cells (lungs) c. Histiocytes (Liver) d. Microglia (Brain) e. Spleen/Bone marrow sinusoids</p> Signup and view all the answers

    _____ = In birds and in some species of animals

    <p>Liver (D)</p> Signup and view all the answers

    It is the name of anemia that develops where there is deficiency of Vitamin B12.

    <p>Pernicious Anemia (B)</p> Signup and view all the answers

    It is the site where a red blood cell can be destroyed in birds.

    <p>Liver (A)</p> Signup and view all the answers

    It is formed from iron, and will be reused for the formation of Hgb.

    <p>Heme (D)</p> Signup and view all the answers

    It is the animal that has the shortest lifespan.

    <p>Chicken (D)</p> Signup and view all the answers

    It is the structure in the red blood cell that carries oxygen.

    <p>Hemoglobin (C)</p> Signup and view all the answers

    It is a polypeptide chain and will be released by the macrophage into the blood circulation to be reused.

    <p>Globin (D)</p> Signup and view all the answers

    It is responsible for the formation of bile)

    <p>Liver (A)</p> Signup and view all the answers

    Flashcards

    Red Blood Cells

    These cells contain hemoglobin which carries oxygen to different parts of the body. They also have enzymes that help transport carbon dioxide.

    Blood

    The fluid that transports oxygen, nutrients, and removes waste products.

    Mammalian Red Blood Cells

    Red blood cells in mammals are typically shaped like flattened discs with a dip in the center, lack a nucleus, and can't move on their own.

    Polycythemia

    An increase in the number of red blood cells circulating in the blood.

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    Anemia

    A decrease in the number of red blood cells circulating in the blood.

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    WBC:RBC Ratio

    The ratio of white blood cells to red blood cells is approximately 1:7.

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    Maturity of Red Blood Cells

    The stage of development of the red blood cell.

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    Hemopoietic Organs

    Organs involved in the production of blood cells, except the pancreas.

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    Yolk Sac in Blood Cell Production

    The yolk sac is the primary site of blood cell production during embryonic development.

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    Avians Red Blood Cells

    Red blood cells in birds have a different shape, they are oval, have a nucleus, and are not motile.

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    Liver as Blood Cell Production Site

    The liver, along with the spleen and lymph nodes, is the main organ of blood cell production during the second trimester of gestation.

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    Red Blood Cell Size

    As red blood cells mature, they decrease in size.

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    Bone Marrow as Blood Cell Production Site

    The bone marrow is the primary site of blood cell production in later gestation and after birth.

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    Central Pallor

    The central pallor is the lighter center of the red blood cell, resulting from the lack of hemoglobin in that area.

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    Hemo

    The term 'hemo' refers to blood.

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    Pleuripotent Hemopoietic Stem Cell

    The origin of all blood cells is the pleuripotent hemopoietic stem cell.

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    Poietic

    Poiesis refers to the process of genesis or formation.

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    Committed Stem Cells

    In the bone marrow, all blood cells eventually become committed stem cells for the formation of red blood cells, white blood cells, and megakaryocytes.

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    Proerythroblast

    The proerythroblast is a nucleated cell where the formation of hemoglobin begins.

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    Reticulocytes

    Reticulocytes are immature red blood cells that still have a nucleus.

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    Erythrocytes

    Erythrocytes are mature red blood cells that have lost their nucleus.

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    Nucleated Red Blood Cells

    The presence of nucleated red blood cells in a blood smear indicates an abnormal condition where maturation is delayed.

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    Megakaryocyte

    Megakaryocytes are large cells that later fragment into platelets.

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    Iron in Hemoglobin Formation

    Iron is an essential component for the formation of hemoglobin, the protein that carries oxygen.

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    Erythropoietin

    Erythropoietin, a hormone produced by the kidneys, is vital for red blood cell formation.

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    Erythropoietin Secretion

    Erythropoietin is secreted by kidney cells in response to low tissue oxygen.

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    Horse RBC Lifespan

    The life span of red blood cells in horses is approximately 140-150 days.

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    Dog RBC Lifespan

    The life span of red blood cells in dogs is approximately 100-130 days.

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    Cat RBC Lifespan

    The life span of red blood cells in cats is approximately 70-80 days.

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    Adult Ruminant RBC Lifespan

    The life span of red blood cells in adult ruminants is approximately 125-150 days.

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    Young Ruminant RBC Lifespan

    The life span of red blood cells in young ruminants is approximately 50-100 days.

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    Pig RBC Lifespan

    The life span of red blood cells in pigs is approximately 51-79 days.

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    RBC Maturation Requirements

    Vitamin B12 (Cyanocobalamin) and folic acid (Pteroylglutamic acid) are essential for the maturation of red blood cells.

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    Chicken RBC Lifespan

    The life span of red blood cells in chickens is approximately 20-30 days.

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    Duck RBC Lifespan

    The life span of red blood cells in ducks is approximately 30-40 days.

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    Megaloblastic Anemia

    Megaloblastic anemia is characterized by large red blood cells due to problems with maturation or cell membrane development.

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    Microcytic Hypochromic Anemia

    This type of anemia is due to a deficiency in iron and small, pale red blood cells.

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    Erythroblastosis Fetalis

    This condition occurs when the maternal and fetal blood types are incompatible.

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    Sickle Cell Anemia

    This anemia results from an abnormal hemoglobin, causing red blood cells to become sickle-shaped.

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    Rubriblast

    The rubriblast is the precursor to the proerythroblast and starts the formation of hemoglobin.

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    Basophilic Erythroblasts

    Basophilic erythroblasts are immature red blood cells.

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    Reticulocytosis

    An increase in the number of reticulocytes in the blood.

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    Hypoxia

    A decrease in oxygen levels in the tissues.

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    Kidney Response to Hypoxia

    Low tissue oxygenation stimulates the kidneys to release erythropoietin, triggering the production of red blood cells.

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    Erythropoietin Production Site

    The juxtaglomerular cells (JG cells) in the kidneys release erythropoietin.

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    Pernicious Anemia

    Pernicious Anemia is caused by a deficiency in vitamin B12.

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    RBC Formation Requirements

    Essential substances for red blood cell formation (except calcium).

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    Kupffer Cells

    Kupffer cells are specialized macrophages found in the liver that remove worn-out red blood cells.

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    Spleen

    The spleen is an organ that plays a role in filtering blood and removing old red blood cells. It's also responsible for recycling iron from old red blood cells.

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