Cell Injury, Death and Adaptation
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Questions and Answers

It talks about signs and symptoms of a disease

Clinical Manifestations

Study of the cause of disease

Etiology

The Study of Disease

Pathology

structural and functional units of tissues and organs

<p>Cells</p> Signup and view all the answers

The 3 Cell Proliferation

<p>Labile, Stable, Permanent</p> Signup and view all the answers

it results in a new steady state and preserving viability

<p>Adaptation</p> Signup and view all the answers

The capability of cells in adjusting their structures and functions in response to various psychological and pathological conditions.

<p>Cellular Adaptation</p> Signup and view all the answers

Cell Proliferation that is continuously dividing

<p>Labile Cells</p> Signup and view all the answers

Cell Proliferation that is nondividing

<p>Permanent Cells</p> Signup and view all the answers

occurs due to normal stressor/stimmuli and results to enhanced function.

<p>Physiologic</p> Signup and view all the answers

positively counteract reduction in function

<p>Compensatory</p> Signup and view all the answers

Cell Proliferation that is quiescent.

<p>Stable Cells</p> Signup and view all the answers

occurs due to an abnormal stressor/stimuli and results in dysfunction and mortality

<p>Pathologic</p> Signup and view all the answers

Increased in number of cells in an organ or tissue and may sometime co-exist with hypertrophy.

<p>Hyperplasia</p> Signup and view all the answers

Increased in the size of cells which results in enlargement of the organs.

<p>Hypertrophy</p> Signup and view all the answers

Shrinkage in the size of the cell by loss of substance.

<p>Atrophy</p> Signup and view all the answers

A reversible change in which one adult cell type is replaced by another adult cell type.

<p>Metaplasia</p> Signup and view all the answers

3 types of Metaplasia

<p>Squamous Osseous Myeloid</p> Signup and view all the answers

Atypical Proliferative changes due to chronic irritation or inflammation

<p>Dysplasia</p> Signup and view all the answers

considered less serious, do not spread, and not life-threatening

<p>Benign</p> Signup and view all the answers

It means “new growth” and a tumor.

<p>Neoplasia</p> Signup and view all the answers

Cells are undifferentiated with variable nuclear and cell structure and numerous mitotic figures

<p>Anaplasia</p> Signup and view all the answers

Incomplete development of an organ so that it fails to reach adult size

<p>Hypoplasia</p> Signup and view all the answers

Cell adaptation that are reversible changes.

<p>Atrophy Hypertrophy Hyperplasia Metaplasia</p> Signup and view all the answers

This means cancerous

<p>Malignant</p> Signup and view all the answers

Failure of cell production

<p>Aplasia</p> Signup and view all the answers

denotes pathologic changes that can be reversed when the stimulus is removed, or if the cause of injury is mild

<p>Reversible cell injury</p> Signup and view all the answers

denotes pathologic changes that are permanent and cause cell death

<p>Irreversible injury</p> Signup and view all the answers

Oxygen deprivation

<p>Hypoxic Cell Injury</p> Signup and view all the answers

Causes of Cell Injury

<p>Hypoxic Cell Injury Free Radical Injury Physical Agent Chemical Agent Infectious Agent Immune System Genetic Imbalance Nutritional Imbalance Aging</p> Signup and view all the answers

vital process that helps eliminate unwanted cells

<p>Apoptosis</p> Signup and view all the answers

cardiorespiratory failure

<p>Inadequate oxygenation</p> Signup and view all the answers

changes produced by enzymatic digestion of dead cellular elements

<p>Necrosis</p> Signup and view all the answers

this is when dead cells undergo disintegration and affected tissue is liquified

<p>Liquefactive necrosis</p> Signup and view all the answers

Necrosis of fat by pancreatic enzymes

<p>Enzymatic fat necrosis</p> Signup and view all the answers

loss of blood supply

<p>Ischemia</p> Signup and view all the answers

internally programmed series of events

<p>Unwanted cells</p> Signup and view all the answers

Morphologic expression of cell death

<p>Necrosis</p> Signup and view all the answers

typically seen in hypoxic environment

<p>Coagulative necrosis</p> Signup and view all the answers

direct effects of bacterial toxins; cytopathic effects of viruses.

<p>Infectious Agents</p> Signup and view all the answers

specific form of coagulation necrosis typically caused by mycobacteria

<p>Caseous necrosis</p> Signup and view all the answers

usually with superimposed infection

<p>Gangrenous necrosis</p> Signup and view all the answers

Causes of Apoptosis

<p>Physiologic Pathologic</p> Signup and view all the answers

2 ways on how death of cells occurs

<p>Necrosis Apoptosis</p> Signup and view all the answers

traumatic fat necrosis

<p>Fat Necrosis</p> Signup and view all the answers

restricted to necrosis involving spirochaetal infections

<p>Gummatous necrosis</p> Signup and view all the answers

caused by immune mediated vascular damage

<p>Fibrinoid necrosis</p> Signup and view all the answers

how many cells are produced every second by mitosis and a similar number die by apoptosis in the human body

<p>100,000</p> Signup and view all the answers

Embryogenesis and fetal development; Elimination of self reactive lymphocytes

<p>Physiologic Apoptosis</p> Signup and view all the answers

it is due to blockage of the venous drainage of an organ or tissue

<p>Haemorrhagic necrosis</p> Signup and view all the answers

Neutralization of Free Radicals

<p>Spontaneous Delay Superoxide dismutase Glutathione Catalase Endogenous and Exogenous antioxidants</p> Signup and view all the answers

“per”

<p>throughout</p> Signup and view all the answers

DNA damage due to radiation and chemotherapy

<p>Pathologic Apoptosis</p> Signup and view all the answers

“neo”

<p>new</p> Signup and view all the answers

“multi”

<p>many</p> Signup and view all the answers

“inter”

<p>between</p> Signup and view all the answers

“intra”

<p>within</p> Signup and view all the answers

“micro”

<p>small</p> Signup and view all the answers

“hyper”

<p>above</p> Signup and view all the answers

“hypo”

<p>below</p> Signup and view all the answers

“epi”

<p>covering</p> Signup and view all the answers

“andr”

<p>male</p> Signup and view all the answers

“bio”

<p>life</p> Signup and view all the answers

“an”

<p>without</p> Signup and view all the answers

“cyst”

<p>bladder</p> Signup and view all the answers

“-ectas”

<p>extension</p> Signup and view all the answers

“auto”

<p>self</p> Signup and view all the answers

“-cele”

<p>swelling</p> Signup and view all the answers

“-scopy”

<p>visual examination</p> Signup and view all the answers

“-pexy”

<p>surgical fixation</p> Signup and view all the answers

“-plasty”

<p>surgical repair</p> Signup and view all the answers

Flashcards

What is Pathology?

The study of disease.

What is Etiology?

The study of the cause of disease.

What are Clinical Manifestations?

Signs and symptoms of a disease.

What are Cells?

Structural and functional units of tissues and organs.

Signup and view all the flashcards

What is Cellular Adaptation?

The capability of cells in adjusting their structures and functions in response to various psychological and pathological conditions.

Signup and view all the flashcards

What is Metaplasia?

A reversible change in which one adult cell type is replaced by another adult cell type.

Signup and view all the flashcards

What are Labile Cells?

Continuously dividing cells.

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What are Permanent Cells?

Nondividing cells.

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What are Stable Cells?

Quiescent cells.

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What is Physiologic Adaptation?

Occurs due to normal stressor/stimuli and results to enhanced function.

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What is Pathologic Adaptation?

Occurs due to an abnormal stressor/stimuli and results in dysfunction and mortality.

Signup and view all the flashcards

What is Hypertrophy?

Increased in the size of cells, which results in enlargement of the organs.

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What is Hyperplasia?

Increased in the number of cells in an organ or tissue.

Signup and view all the flashcards

What is Atrophy?

Shrinkage in the size of the cell by loss of substance.

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What is Dysplasia?

Atypical proliferative changes due to chronic irritation or inflammation.

Signup and view all the flashcards

What is Neoplasia?

It means “new growth” and a tumor.

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What is Anaplasia?

Cells are undifferentiated with variable nuclear and cell structure and numerous mitotic figures.

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What is Hypoplasia?

Incomplete development of an organ so that it fails to reach adult size.

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What is Benign?

Less serious, do not spread, and not life-threatening.

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What is Malignant?

This means cancerous.

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What is Aplasia?

Failure of cell production.

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What is Reversible Cell Injury?

Denotes pathologic changes that can be reversed when the stimulus is removed, or if the cause of injury is mild.

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What is Irreversible Cell Injury?

Denotes pathologic changes that are permanent and cause cell death.

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What is Hypoxic Cell Injury?

Oxygen deprivation.

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What is Necrosis?

Changes produced by enzymatic digestion of dead cellular elements.

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What is Apoptosis?

Internally programmed series of events.

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What is Liquefactive Necrosis?

This is when dead cells undergo disintegration and affected tissue is liquified.

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What is Enzymatic Fat Necrosis?

Necrosis of fat by pancreatic enzymes.

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What is Caseous Necrosis?

Specifically a type of coagulative necrosis typically caused by mycobacteria.

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What is Gangrenous Necrosis?

Usually with superimposed infection.

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What is Fibrinoid Necrosis?

Caused by immune mediated vascular damage.

Signup and view all the flashcards

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