Lecture 30 – The Fate of Pyruvate

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Questions and Answers

What is required for glycolysis to continue functioning?

  • Oxygen
  • NAD+ (correct)
  • Glucose
  • ADP

Under aerobic conditions, what happens to pyruvate?

  • It is converted to lactate.
  • It is oxidized in the citric acid cycle. (correct)
  • It is fermented to ethanol.
  • It is converted to glucose.

What is the primary purpose of fermentation?

  • To produce glucose
  • To regenerate NAD+ (correct)
  • To synthesize proteins
  • To release oxygen

Which of the following is a product of lactate fermentation?

<p>Lactate (C)</p> Signup and view all the answers

What is the fate of pyruvate in anaerobic conditions for animal cells?

<p>It is reduced to lactate. (B)</p> Signup and view all the answers

Which of the following environments can lead to temporary anaerobic conditions?

<p>Muscle cells during intense exercise (B)</p> Signup and view all the answers

What is the ΔG° value for the complete oxidation of glucose?

<p>-2.9 x 10³ kJ/mol (B)</p> Signup and view all the answers

Which cofactor is necessary for the decarboxylation of pyruvate?

<p>Thiamine pyrophosphate (TPP) (C)</p> Signup and view all the answers

What is the role of the pyruvate dehydrogenase complex?

<p>To convert pyruvate to acetyl-CoA (B)</p> Signup and view all the answers

What happens to acetyl-CoA after it is produced from pyruvate?

<p>It enters the citric acid cycle. (B)</p> Signup and view all the answers

What is the function of the dihydrolipoamide in the pyruvate dehydrogenase complex?

<p>It transfers acetyl groups to CoA. (B)</p> Signup and view all the answers

How does phosphorylation affect the pyruvate dehydrogenase complex?

<p>It inactivates the complex. (B)</p> Signup and view all the answers

What are anaplerotic reactions?

<p>Reactions that replenish citric acid cycle intermediates (B)</p> Signup and view all the answers

Which of the following is a key intermediate that can be replenished via pyruvate carboxylation?

<p>Oxaloacetate (C)</p> Signup and view all the answers

What is one consequence of a vitamin B1 deficiency?

<p>Neurological disorders like beriberi (B)</p> Signup and view all the answers

What is the effect of adding pyruvate along with organic acids like citrate?

<p>Increased oxygen consumption (B)</p> Signup and view all the answers

What does malonate inhibit in the citric acid cycle?

<p>The conversion of succinate to fumarate (B)</p> Signup and view all the answers

What are the three names used to refer to the citric acid cycle?

<p>Krebs cycle, tricarboxylic acid cycle, TCA cycle (C)</p> Signup and view all the answers

How does the pyruvate dehydrogenase complex increase efficiency?

<p>Through non-covalent interactions between enzymes (B)</p> Signup and view all the answers

What is the primary role of the electron transport chain?

<p>To oxidize NADH (D)</p> Signup and view all the answers

What triggers the activation of the pyruvate dehydrogenase complex?

<p>High levels of ADP and NAD+ (B)</p> Signup and view all the answers

What is the main product of the oxidative decarboxylation of pyruvate?

<p>Acetyl-CoA (C)</p> Signup and view all the answers

Which reaction does pyruvate carboxylase catalyze?

<p>Conversion of pyruvate to oxaloacetate (B)</p> Signup and view all the answers

What is the role of ADP in the regulation of the pyruvate dehydrogenase complex?

<p>It activates the complex. (B)</p> Signup and view all the answers

Which compound acts as both electron donor and acceptor during fermentation?

<p>Glucose (B)</p> Signup and view all the answers

Which type of reaction is facilitated by the pyruvate dehydrogenase complex?

<p>Decarboxylation (B)</p> Signup and view all the answers

What is the significance of the sparker effect in metabolism?

<p>It indicates the catalytic activity of organic acids. (B)</p> Signup and view all the answers

What does the term "cyclic nature" refer to in the citric acid cycle?

<p>The regeneration of cycle intermediates (B)</p> Signup and view all the answers

What is the primary role of the cofactor lipoamide in the pyruvate dehydrogenase complex?

<p>It picks up acetyl groups. (D)</p> Signup and view all the answers

Why is the control of the pyruvate dehydrogenase complex crucial in metabolism?

<p>It determines the direction of acetyl-CoA utilization. (B)</p> Signup and view all the answers

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