3Rs and Animal Use Protocol Lecture 3 Summary
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Questions and Answers

What is the main purpose of the 3Rs principles mentioned in the text?

  • To substitute non-animal methods with animals in experiments
  • To increase pain and distress experienced by animals in experiments
  • To maximize the number of animals used in experiments
  • To minimize the number of animals used in experiments (correct)

Who were the scientists involved in the project that led to the publication of 'Principles of Humane Experimental Techniques'?

  • Charles Hume and R.L. Burch
  • W.M.S. Russel and Dr. Abeer Mahmoud Badr
  • Dr. Abeer Mahmoud Badr and Charles Hume
  • Microbiologist R.L. Burch and Zoologist W.M.S. Russel (correct)

What is considered a prerequisite for successful animal experiments?

  • Maximizing the pain and distress of animals
  • Using as many animals as possible
  • Treating animals humanely (correct)
  • Ignores the humane treatment of animals

Which of the following does NOT represent one of the 3Rs principles mentioned?

<p>Increase the pain and distress of animals during experiments (D)</p> Signup and view all the answers

When did the proposal for humane experimental techniques first surface?

<p>1954 (C)</p> Signup and view all the answers

What does the term '3Rs' refer to in the context of animal experiments?

<p>Replacement, Reduction, Replication (D)</p> Signup and view all the answers

What is considered a method of 'full replacement' in animal experiments according to the text?

<p>Organs-on-microchips (B)</p> Signup and view all the answers

What is a major disadvantage mentioned in the text regarding in vitro systems as replacements in animal experiments?

<p>Loss of organ structure &amp; cell-cell interaction (A)</p> Signup and view all the answers

What is the difference between 'Duplication' and 'Replication' in animal experiments as per the text?

<p>'Duplication' is performed without scientific justification while 'Replication' is scientifically justified. (A)</p> Signup and view all the answers

What does 'Reduction and Species Selection' focus on in animal experiments according to the text?

<p>Gathering maximum information from each animal (C)</p> Signup and view all the answers

Why is 'Experimental Design' highlighted as good scientific practice in animal experiments as per the text?

<p>To ensure the validity of the experiment (B)</p> Signup and view all the answers

Which organization awarded the Russell and Burch Award in 1990?

<p>Humane Society of United States (A)</p> Signup and view all the answers

'Liver on a chip' is an example of a method used for what purpose in animal experiments?

<p>Partial replacement (A)</p> Signup and view all the answers

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