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3Rs and Animal Use Protocol Lecture 3 Summary

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3Rs and Animal Use Protocol Lecture 3 Summary

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Questions and Answers

What is the main purpose of the 3Rs principles mentioned in the text?

To substitute non-animal methods with animals in experiments

To increase pain and distress experienced by animals in experiments

To maximize the number of animals used in experiments

To minimize the number of animals used in experiments (correct)

Who were the scientists involved in the project that led to the publication of 'Principles of Humane Experimental Techniques'?

Charles Hume and R.L. Burch

W.M.S. Russel and Dr. Abeer Mahmoud Badr

Dr. Abeer Mahmoud Badr and Charles Hume

Microbiologist R.L. Burch and Zoologist W.M.S. Russel (correct)

What is considered a prerequisite for successful animal experiments?

Maximizing the pain and distress of animals

Using as many animals as possible

Treating animals humanely (correct)

Ignores the humane treatment of animals

Which of the following does NOT represent one of the 3Rs principles mentioned?

Increase the pain and distress of animals during experiments Signup and view all the answers

When did the proposal for humane experimental techniques first surface?

1954 Signup and view all the answers

What does the term '3Rs' refer to in the context of animal experiments?

Replacement, Reduction, Replication Signup and view all the answers

What is considered a method of 'full replacement' in animal experiments according to the text?

Organs-on-microchips Signup and view all the answers

What is a major disadvantage mentioned in the text regarding in vitro systems as replacements in animal experiments?

Loss of organ structure & cell-cell interaction Signup and view all the answers

What is the difference between 'Duplication' and 'Replication' in animal experiments as per the text?

'Duplication' is performed without scientific justification while 'Replication' is scientifically justified. Signup and view all the answers

What does 'Reduction and Species Selection' focus on in animal experiments according to the text?

Gathering maximum information from each animal Signup and view all the answers

Why is 'Experimental Design' highlighted as good scientific practice in animal experiments as per the text?

To ensure the validity of the experiment Signup and view all the answers

Which organization awarded the Russell and Burch Award in 1990?

Humane Society of United States Signup and view all the answers

'Liver on a chip' is an example of a method used for what purpose in animal experiments?

Partial replacement Signup and view all the answers