Animal Research Ethics: 3Rs and ASPA
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Questions and Answers

What is the primary reason for not inflicting pain or suffering unnecessarily in animal research?

  • For ethical reasons and to avoid negative public perception (correct)
  • To reduce the cost of animal care and maintenance
  • To ensure the accuracy of scientific results
  • To comply with the 3R's principle

What is the main purpose of the Animal Scientific Procedures Act 1986?

  • To encourage the development of non-animal testing methods
  • To regulate and protect animals used in scientific procedures (correct)
  • To provide funding for animal research projects
  • To promote the use of animals in scientific studies

What is the status of humans under the Animal Scientific Procedures Act 1986?

  • They are protected under ASPA
  • They are exempt from ASPA (correct)
  • They are only protected during certain stages of development
  • They are not mentioned in ASPA

At what point are fish and amphibia protected under the Animal Scientific Procedures Act 1986?

<p>Once they can feed independently (B)</p> Signup and view all the answers

Why might ASPA not apply to certain individuals or organizations?

<p>Because they are not using animals for scientific purposes (B)</p> Signup and view all the answers

What is the primary reason for avoiding unnecessary pain and suffering in animal research?

<p>To avoid changing the system being investigated (C)</p> Signup and view all the answers

What is the minimum requirement for an animal to be considered for re-homing?

<p>The animal must be in good health and pose no human health risks (D)</p> Signup and view all the answers

What is the maximum level of pain, suffering, or distress that a procedure can cause before it is classified as severe?

<p>Long-lasting severe pain, suffering, or distress (B)</p> Signup and view all the answers

What is the purpose of a Project Licence in animal research?

<p>To outline the project goals and methods (C)</p> Signup and view all the answers

What is the main principle behind the 'Replacement' aspect of the 3R's in animal research?

<p>Replacing animals with alternative models or methods (C)</p> Signup and view all the answers

What is the fate of an animal that has undergone a 'non-recovery' procedure?

<p>The animal is humanely killed after the procedure (B)</p> Signup and view all the answers

Flashcards

Why avoid unnecessary pain in animal research?

The ethical obligation to minimize pain and suffering in animal research, which also contributes to the reliability of research results.

Purpose of ASPA

The Animal Scientific Procedures Act 1986 aims to ensure the humane treatment of animals used in scientific research by regulating procedures and promoting ethical practices.

Humans and ASPA

Humans are not subject to the regulations of the Animal Scientific Procedures Act 1986.

ASPA protection for fish and amphibians

Fish and amphibians are protected under the ASPA once they reach the stage where they can feed themselves independently.

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Exemptions from ASPA

Individuals and organizations not involved in scientific research using animals are not subject to the ASPA regulations.

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Project License and ASPA

Performing procedures without a valid project license is a serious violation of ASPA regulations.

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Replacement (3R's)

The 'Replacement' principle encourages the use of non-animal methods like computer simulations or cell cultures whenever possible in research.

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Recovery procedures under ASPA

Animals undergoing procedures from which they are expected to recover must be provided with appropriate care and monitoring.

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Animals unsuitable for re-homing

The Animal Scientific Procedures Act 1986 aims to ensure the humane treatment of animals used in scientific research by regulating procedures and promoting ethical practices.

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Severe procedures under ASPA

Procedures causing prolonged severe pain, suffering, or distress are classified as severe under ASPA guidelines.

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Non-recovery procedures under ASPA

Animals undergoing procedures from which they are not expected to recover are humanely euthanized after the procedure concludes.

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Study Notes

Ethics in Animal Research

  • Unnecessary infliction of pain or suffering is avoided for ethical reasons and to maintain a positive public image of research.

The 3Rs in Animal Research

  • Reduction: minimize the number of animals used
  • Refinement: minimize suffering and improve animal welfare
  • Replacement: replace animals with alternative methods or models

Animal Scientific Procedures Act (ASPA) 1986

  • Legislation protecting animals used in scientific studies
  • Applies to the use of animals for scientific purposes, not for non-scientific reasons

Protected Animals

  • All living vertebrates, except humans
  • Cephalopods (e.g., octopuses, squids)
  • Fish and amphibians: protected once they can feed independently
  • Cephalopods: protected from the point of hatching
  • Embryonic and foetal forms of mammals, birds, and reptiles: protected during the last third of gestation or incubation

Procedure Classifications

  • Regulated procedure: equivalent to or greater than the pain caused by inserting a hypodermic needle
  • Non-recovery: procedure under general anesthesia from which the animal will not recover consciousness
  • Mild: short-term mild pain, suffering, or distress
  • Moderate: short-term moderate pain, suffering, or distress, or long-lasting mild pain, suffering, or distress
  • Severe: severe pain, suffering, or distress, or long-lasting moderate pain, suffering, or distress

Licensing

  • Project licence: outlines project goals, methods, locations, number of animals, and types of regulated procedures
  • Personal licence: outlines individual permissions within a project

Animal Fates

  • Humanely killed
  • Re-used (only if same results cannot be obtained from a naive animal)
  • Re-homed (must be in good health, pose no human health risks, and have undergone an approved socialisation scheme)
  • Setting free

Penalties for Non-Compliance

  • Temporary withdrawal of licence
  • Permanent withdrawal of licence
  • Financial penalty
  • Jail sentence

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Learn about the principles guiding animal research, including the 3Rs of Reduction, Refinement, and Replacement, and the Animal Scientific Procedures Act 1986 (ASPA) that regulates animal use in scientific studies and testing. Understand the importance of ethical considerations in animal research and testing.

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