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Questions and Answers

What characteristic of a drug describes its ability to produce a therapeutic effect at a lower dose compared to another drug?

  • Efficacy
  • Affinity
  • Toxicity
  • Potency (correct)

Which term describes the maximum effect that a drug can produce regardless of dosage?

  • Efficacy (correct)
  • Therapeutic range
  • Potency
  • Side effect potential

If a drug requires a lower dosage to achieve the same pharmacological effect as another drug, what can be inferred about its potency?

  • It has no effect.
  • It is equally potent.
  • It is less potent.
  • It is more potent. (correct)

Which of the following correctly categorizes morphine in terms of efficacy compared to ibuprofen and aspirin?

<p>Morphine has greater efficacy than aspirin. (B)</p> Signup and view all the answers

What is the relationship between dose response and the therapeutic response in pharmacology?

<p>Dose response helps explain variability in therapeutic response. (A)</p> Signup and view all the answers

Which of the following statements about efficacy and potency is true?

<p>Efficacy is more significant for achieving a therapeutic effect than potency. (D)</p> Signup and view all the answers

What differentiates an agonist from an antagonist in pharmacology?

<p>An antagonist reverses the effect of an agonist. (D)</p> Signup and view all the answers

In the context of drug comparison, what does it mean if two drugs have the same efficacy?

<p>They are equally effective at their maximum dose. (D)</p> Signup and view all the answers

Which aspect is generally more crucial to patients when considering medication?

<p>Efficacy of the drug (B)</p> Signup and view all the answers

What is a receptor in the context of drug action?

<p>A cellular component that binds endogenous molecules (D)</p> Signup and view all the answers

Which type of receptor is opened by changes in voltage across the plasma membrane?

<p>Voltage-gated channels (B)</p> Signup and view all the answers

How does a drug typically attach to its receptor?

<p>In a specific docking manner like a thumb drive to a USB port (A)</p> Signup and view all the answers

What could potentially weaken the binding between a drug and its receptor?

<p>Changes in the drug's molecular structure (C)</p> Signup and view all the answers

Which statement best describes how drugs produce their effects?

<p>They act by modulating existing physiological processes through receptors. (C)</p> Signup and view all the answers

What are the majority of drug receptors classified as?

<p>Proteins (D)</p> Signup and view all the answers

What type of channel is activated by the release of neurotransmitters into the synapse?

<p>Chemical gated channels (B)</p> Signup and view all the answers

What is the role of second messenger events triggered by drug binding?

<p>They involve the conversion of ATP to cyclic AMP and intracellular calcium release. (B)</p> Signup and view all the answers

Which type of molecules can act as intracellular receptors?

<p>DNA and enzymes found in the cytoplasm. (A)</p> Signup and view all the answers

What distinguishes alpha and beta receptor subtypes in pharmacology?

<p>They allow for more specific drug action with fewer side effects. (A)</p> Signup and view all the answers

How do some drugs operate independently of cellular receptors?

<p>By changing cellular membrane permeability or altering pump activity. (B)</p> Signup and view all the answers

What are nonspecific cellular responses?

<p>Effects that result from altering cellular membrane excitability. (B)</p> Signup and view all the answers

What therapeutic consequences can result from drug-receptor interactions?

<p>Interactions can lead to increased or decreased cellular activity. (B)</p> Signup and view all the answers

What is the significance of receptor subtypes in drug development?

<p>They enable the fine-tuning of pharmacologic therapies. (D)</p> Signup and view all the answers

Which substances are known to bind with intracellular components?

<p>Steroid medications, vitamins, and hormones. (D)</p> Signup and view all the answers

What is the primary characteristic of an agonist in pharmacology?

<p>It mimics the effect of an endogenous regulatory molecule. (B)</p> Signup and view all the answers

Which drug is known to compete with acetylcholine for its receptors?

<p>Atropine (A)</p> Signup and view all the answers

What is the definition of a partial agonist?

<p>It binds to a receptor but produces a weaker response than an agonist. (D)</p> Signup and view all the answers

What effect do functional antagonists have on agonists?

<p>They inhibit agonist effects through pharmacokinetic changes. (A)</p> Signup and view all the answers

What does the term efficacy refer to in pharmacology?

<p>The maximal response a drug can produce. (C)</p> Signup and view all the answers

When comparing morphine to codeine, what does the greater pain relief from 10 mg of morphine indicate?

<p>Morphine has a higher efficacy than codeine. (C)</p> Signup and view all the answers

Which of the following statements best describes antagonists?

<p>They prevent endogenous chemicals from binding to receptors. (D)</p> Signup and view all the answers

Butorphanol is categorized as which type of drug?

<p>Partial agonist (A)</p> Signup and view all the answers

Flashcards

Potency

A drug's ability to produce an effect at a lower dose compared to another drug in the same class.

Efficacy

The maximum effect a drug can produce, regardless of the dose.

Grade-Dose Response Relationship

A fundamental concept in pharmacology that studies a patient's response to different doses of a drug.

Agonist

A drug that binds to a receptor and activates it, mimicking the action of a natural substance.

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Partial Agonist

A drug that binds to a receptor but produces a weaker response compared to a full agonist.

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Antagonist

A drug that blocks the action of another drug or natural substance by binding to its receptor without activating it.

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Receptor

A specific protein on a cell that a drug can bind to and elicit a response.

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What is more important, potency or efficacy?

Efficacy is more important for the success of pharmacotherapy because it determines the maximum effect a drug can achieve, while potency only indicates how much of a drug is needed to achieve a certain effect.

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Second messenger

A molecule inside a cell that relays signals from a receptor on the cell surface to the interior of the cell, triggering biochemical changes.

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Intracellular receptors

Receptors located inside the cell, often within the cytoplasm or nucleus, that bind to drugs or hormones that can pass through the cell membrane.

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How do medications affect protein synthesis?

Some medications bind to intracellular receptors and can influence protein synthesis by either stimulating or inhibiting its processes.

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Receptor subtypes

Different versions of the same receptor type that have slightly different structures and responses to drugs.

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Nonspecific cellular responses

Drug actions that don't involve binding to specific cellular receptors but instead affect cellular functions in a more general way.

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Permeability

The ability of a substance to pass through a membrane, often influenced by drugs.

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Depresing membrane excitability

A drug action that reduces the ability of a cell membrane to generate electrical signals.

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Cellular pumps

Specialized proteins embedded in cell membranes that transport substances across the membrane, often affected by drugs.

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What is the biggest difference between efficacy and potency?

Efficacy is the maximum response a drug can produce, while potency is the amount of drug needed to achieve a certain effect.

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Why is efficacy more important than potency in pharmacotherapy?

Efficacy determines the maximum effect a drug can achieve, regardless of dose, which is crucial for successful treatment.

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What are receptors?

Receptors are protein molecules on cells that drugs bind to, triggering specific responses.

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How do drugs influence the body?

Drugs modulate existing physiological and biochemical processes by interacting with specific receptor molecules in the body.

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What's an important fact about receptors?

Receptors exist in the body to bind endogenous molecules like hormones, neurotransmitters, and growth factors. They are not solely for drugs.

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Explain the comparison to a USB port.

A drug attaches to its receptor like a USB drive docks to a computer port. The fit is specific and small changes can drastically change the binding.

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What are the types of receptors by mode of activation?

Receptors can be activated by voltage changes across the membrane (voltage-gated) or by binding of neurotransmitters (chemical-gated).

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What happens when a voltage-gated channel opens?

When an electrical signal reaches the nerve ending, voltage-gated calcium channels open allowing calcium to enter and trigger the release of neurotransmitters.

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What does it mean when a drug is more potent than another?

A drug is more potent than another if it produces a desired effect at a lower dose compared to the other drug.

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What is efficacy?

The maximum effect a drug can produce, regardless of the dose.

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What are functional antagonists?

Drugs that inhibit the effects of an agonist not by competing for a receptor, but by affecting its absorption, metabolism, or excretion.

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What is the relationship between agonists and antagonists?

They can interact with each other, potentially influencing the effects of both drugs.

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What are drug-drug and drug-food interactions?

The effects of taking multiple drugs or consuming certain foods along with a medication.

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Study Notes

Pharmacology Lecture Notes

  • Pharmacodynamics is the study of how a drug affects the body
  • Learning objectives include comparing potency and efficacy, distinguishing between agonists, partial agonists, and antagonists, and explaining the relationship between receptors and drug action
  • Grade-Dose Response: Frequency distribution curves are used to visualize patient variability in responses to medications, both within a population and between individuals. This is fundamental to pharmacology
  • A dose-response relationship graph (Figure 5.3) shows how drug intensity correlates with a log scale of dose; phases 1, 2 and 3 are evident in the graph
  • Potency is a drug's ability to achieve a desired effect at a low dose, compared to other drugs in the same class. Potency is about the amount of drug necessary to produce an effect
  • Efficacy is the maximal effect a drug can produce, regardless of dose, a measure of the drug's ability to produce a therapeutic outcome
  • Efficacy is generally more important than potency in pharmacology
  • Agonist- a drug that produces the same response as an endogenous substance. Agonists can sometimes cause a larger maximal response
  • Partial agonists - produce weaker, less effective responses than a true agonist
  • Antagonist- a drug that blocks the action of an agonist by occupying a receptor
  • Antagonists can compete with agonists for receptor binding sites
  • Functional antagonism is about how a therapy affects pharmacokinetic factors, for instance, by affecting absorption, metabolism, or excretion
  • Different types of receptor interactions are possible
  • Receptors are not limited to plasma membrane, some are intracellular molecules such as DNA or enzymes in the cytoplasm (e.g., steroid medications, vitamins, hormones)
  • New receptor subtypes are consistently being discovered, allowing better "fine-tuning" of pharmacology
  • Drugs can act independently of cell receptors (e.g., osmotic diuretics)
  • Drug-receptor interactions can produce either enhanced or inhibited cellular activity
  • Drugs can mimic the effects of natural regulatory molecules (endogenous substances)
  • Different types of receptors and their specific drug interactions are crucial in pharmacology
  • The ED50, or effective dose in 50% of patients, is used to determine a drug's effectiveness; understanding what occurs in the other 50% is important to consider

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