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Questions and Answers
What characteristic of a drug describes its ability to produce a therapeutic effect at a lower dose compared to another drug?
What characteristic of a drug describes its ability to produce a therapeutic effect at a lower dose compared to another drug?
- Efficacy
- Affinity
- Toxicity
- Potency (correct)
Which term describes the maximum effect that a drug can produce regardless of dosage?
Which term describes the maximum effect that a drug can produce regardless of dosage?
- Efficacy (correct)
- Therapeutic range
- Potency
- Side effect potential
If a drug requires a lower dosage to achieve the same pharmacological effect as another drug, what can be inferred about its potency?
If a drug requires a lower dosage to achieve the same pharmacological effect as another drug, what can be inferred about its potency?
- It has no effect.
- It is equally potent.
- It is less potent.
- It is more potent. (correct)
Which of the following correctly categorizes morphine in terms of efficacy compared to ibuprofen and aspirin?
Which of the following correctly categorizes morphine in terms of efficacy compared to ibuprofen and aspirin?
What is the relationship between dose response and the therapeutic response in pharmacology?
What is the relationship between dose response and the therapeutic response in pharmacology?
Which of the following statements about efficacy and potency is true?
Which of the following statements about efficacy and potency is true?
What differentiates an agonist from an antagonist in pharmacology?
What differentiates an agonist from an antagonist in pharmacology?
In the context of drug comparison, what does it mean if two drugs have the same efficacy?
In the context of drug comparison, what does it mean if two drugs have the same efficacy?
Which aspect is generally more crucial to patients when considering medication?
Which aspect is generally more crucial to patients when considering medication?
What is a receptor in the context of drug action?
What is a receptor in the context of drug action?
Which type of receptor is opened by changes in voltage across the plasma membrane?
Which type of receptor is opened by changes in voltage across the plasma membrane?
How does a drug typically attach to its receptor?
How does a drug typically attach to its receptor?
What could potentially weaken the binding between a drug and its receptor?
What could potentially weaken the binding between a drug and its receptor?
Which statement best describes how drugs produce their effects?
Which statement best describes how drugs produce their effects?
What are the majority of drug receptors classified as?
What are the majority of drug receptors classified as?
What type of channel is activated by the release of neurotransmitters into the synapse?
What type of channel is activated by the release of neurotransmitters into the synapse?
What is the role of second messenger events triggered by drug binding?
What is the role of second messenger events triggered by drug binding?
Which type of molecules can act as intracellular receptors?
Which type of molecules can act as intracellular receptors?
What distinguishes alpha and beta receptor subtypes in pharmacology?
What distinguishes alpha and beta receptor subtypes in pharmacology?
How do some drugs operate independently of cellular receptors?
How do some drugs operate independently of cellular receptors?
What are nonspecific cellular responses?
What are nonspecific cellular responses?
What therapeutic consequences can result from drug-receptor interactions?
What therapeutic consequences can result from drug-receptor interactions?
What is the significance of receptor subtypes in drug development?
What is the significance of receptor subtypes in drug development?
Which substances are known to bind with intracellular components?
Which substances are known to bind with intracellular components?
What is the primary characteristic of an agonist in pharmacology?
What is the primary characteristic of an agonist in pharmacology?
Which drug is known to compete with acetylcholine for its receptors?
Which drug is known to compete with acetylcholine for its receptors?
What is the definition of a partial agonist?
What is the definition of a partial agonist?
What effect do functional antagonists have on agonists?
What effect do functional antagonists have on agonists?
What does the term efficacy refer to in pharmacology?
What does the term efficacy refer to in pharmacology?
When comparing morphine to codeine, what does the greater pain relief from 10 mg of morphine indicate?
When comparing morphine to codeine, what does the greater pain relief from 10 mg of morphine indicate?
Which of the following statements best describes antagonists?
Which of the following statements best describes antagonists?
Butorphanol is categorized as which type of drug?
Butorphanol is categorized as which type of drug?
Flashcards
Potency
Potency
A drug's ability to produce an effect at a lower dose compared to another drug in the same class.
Efficacy
Efficacy
The maximum effect a drug can produce, regardless of the dose.
Grade-Dose Response Relationship
Grade-Dose Response Relationship
A fundamental concept in pharmacology that studies a patient's response to different doses of a drug.
Agonist
Agonist
A drug that binds to a receptor and activates it, mimicking the action of a natural substance.
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Partial Agonist
Partial Agonist
A drug that binds to a receptor but produces a weaker response compared to a full agonist.
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Antagonist
Antagonist
A drug that blocks the action of another drug or natural substance by binding to its receptor without activating it.
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Receptor
Receptor
A specific protein on a cell that a drug can bind to and elicit a response.
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What is more important, potency or efficacy?
What is more important, potency or efficacy?
Efficacy is more important for the success of pharmacotherapy because it determines the maximum effect a drug can achieve, while potency only indicates how much of a drug is needed to achieve a certain effect.
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Second messenger
Second messenger
A molecule inside a cell that relays signals from a receptor on the cell surface to the interior of the cell, triggering biochemical changes.
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Intracellular receptors
Intracellular receptors
Receptors located inside the cell, often within the cytoplasm or nucleus, that bind to drugs or hormones that can pass through the cell membrane.
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How do medications affect protein synthesis?
How do medications affect protein synthesis?
Some medications bind to intracellular receptors and can influence protein synthesis by either stimulating or inhibiting its processes.
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Receptor subtypes
Receptor subtypes
Different versions of the same receptor type that have slightly different structures and responses to drugs.
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Nonspecific cellular responses
Nonspecific cellular responses
Drug actions that don't involve binding to specific cellular receptors but instead affect cellular functions in a more general way.
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Permeability
Permeability
The ability of a substance to pass through a membrane, often influenced by drugs.
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Depresing membrane excitability
Depresing membrane excitability
A drug action that reduces the ability of a cell membrane to generate electrical signals.
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Cellular pumps
Cellular pumps
Specialized proteins embedded in cell membranes that transport substances across the membrane, often affected by drugs.
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What is the biggest difference between efficacy and potency?
What is the biggest difference between efficacy and potency?
Efficacy is the maximum response a drug can produce, while potency is the amount of drug needed to achieve a certain effect.
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Why is efficacy more important than potency in pharmacotherapy?
Why is efficacy more important than potency in pharmacotherapy?
Efficacy determines the maximum effect a drug can achieve, regardless of dose, which is crucial for successful treatment.
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What are receptors?
What are receptors?
Receptors are protein molecules on cells that drugs bind to, triggering specific responses.
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How do drugs influence the body?
How do drugs influence the body?
Drugs modulate existing physiological and biochemical processes by interacting with specific receptor molecules in the body.
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What's an important fact about receptors?
What's an important fact about receptors?
Receptors exist in the body to bind endogenous molecules like hormones, neurotransmitters, and growth factors. They are not solely for drugs.
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Explain the comparison to a USB port.
Explain the comparison to a USB port.
A drug attaches to its receptor like a USB drive docks to a computer port. The fit is specific and small changes can drastically change the binding.
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What are the types of receptors by mode of activation?
What are the types of receptors by mode of activation?
Receptors can be activated by voltage changes across the membrane (voltage-gated) or by binding of neurotransmitters (chemical-gated).
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What happens when a voltage-gated channel opens?
What happens when a voltage-gated channel opens?
When an electrical signal reaches the nerve ending, voltage-gated calcium channels open allowing calcium to enter and trigger the release of neurotransmitters.
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What does it mean when a drug is more potent than another?
What does it mean when a drug is more potent than another?
A drug is more potent than another if it produces a desired effect at a lower dose compared to the other drug.
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What is efficacy?
What is efficacy?
The maximum effect a drug can produce, regardless of the dose.
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What are functional antagonists?
What are functional antagonists?
Drugs that inhibit the effects of an agonist not by competing for a receptor, but by affecting its absorption, metabolism, or excretion.
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What is the relationship between agonists and antagonists?
What is the relationship between agonists and antagonists?
They can interact with each other, potentially influencing the effects of both drugs.
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What are drug-drug and drug-food interactions?
What are drug-drug and drug-food interactions?
The effects of taking multiple drugs or consuming certain foods along with a medication.
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Pharmacology Lecture Notes
- Pharmacodynamics is the study of how a drug affects the body
- Learning objectives include comparing potency and efficacy, distinguishing between agonists, partial agonists, and antagonists, and explaining the relationship between receptors and drug action
- Grade-Dose Response: Frequency distribution curves are used to visualize patient variability in responses to medications, both within a population and between individuals. This is fundamental to pharmacology
- A dose-response relationship graph (Figure 5.3) shows how drug intensity correlates with a log scale of dose; phases 1, 2 and 3 are evident in the graph
- Potency is a drug's ability to achieve a desired effect at a low dose, compared to other drugs in the same class. Potency is about the amount of drug necessary to produce an effect
- Efficacy is the maximal effect a drug can produce, regardless of dose, a measure of the drug's ability to produce a therapeutic outcome
- Efficacy is generally more important than potency in pharmacology
- Agonist- a drug that produces the same response as an endogenous substance. Agonists can sometimes cause a larger maximal response
- Partial agonists - produce weaker, less effective responses than a true agonist
- Antagonist- a drug that blocks the action of an agonist by occupying a receptor
- Antagonists can compete with agonists for receptor binding sites
- Functional antagonism is about how a therapy affects pharmacokinetic factors, for instance, by affecting absorption, metabolism, or excretion
- Different types of receptor interactions are possible
- Receptors are not limited to plasma membrane, some are intracellular molecules such as DNA or enzymes in the cytoplasm (e.g., steroid medications, vitamins, hormones)
- New receptor subtypes are consistently being discovered, allowing better "fine-tuning" of pharmacology
- Drugs can act independently of cell receptors (e.g., osmotic diuretics)
- Drug-receptor interactions can produce either enhanced or inhibited cellular activity
- Drugs can mimic the effects of natural regulatory molecules (endogenous substances)
- Different types of receptors and their specific drug interactions are crucial in pharmacology
- The ED50, or effective dose in 50% of patients, is used to determine a drug's effectiveness; understanding what occurs in the other 50% is important to consider
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