DNA and RNA Synthesis
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Questions and Answers

Which Topoisomerase requires energy?

  • Topoisomerase I
  • Topoisomerase II (correct)
  • Topoisomerase III
  • Topoisomerase IV
  • RNA synthesis is known as

  • Transcription (correct)
  • Translation
  • Replication
  • Encoding
  • The purpose of single-strand DNA binding proteins like replication protein A is to

  • denature DNA making a replication "bubble"
  • Denature helix ahead of replication
  • keep single strand template open (correct)
  • Join Okazaki fragments
  • What polymerase replaces DNA polymerase alpha and replicates the leading strand?

    <p>Polymerase Epsilon</p> Signup and view all the answers

    What polymerase replaces DNA polymerase alpha and replicates the lagging strand?

    <p>Polymerase Delta</p> Signup and view all the answers

    Errors that escape proofreading are corrected by

    <p>Mismatch repair enzymes</p> Signup and view all the answers

    Base Excision Repair removes ___

    <p>Abnormal bases</p> Signup and view all the answers

    Each time a chromosome divides its telomere gets shorter. Short telomeres causes cellular _____

    <p>senescence</p> Signup and view all the answers

    What solves the end replication problem

    <p>Telomerase</p> Signup and view all the answers

    The promoter's function is the same in prokaryotes as it is in eukaryotes. That is it defines the Transcription Start Site, defines which DNA strand is the template, and the direction of transcription.

    <p>True</p> Signup and view all the answers

    RNA Polymerase terminates RNA synthesis when the newly made RNA folds into a

    <p>hairpin</p> Signup and view all the answers

    All three RNA polymerases (I,II,III) are sensitive and can be inhibited by

    <p>Actinomycin D</p> Signup and view all the answers

    Rifampin, a first-line antibiotic against TB, is able to bind eukaryotic RNA polymerases.

    <p>False</p> Signup and view all the answers

    The purpose of the Sigma factor is to help bacterial RNA polymerase recognize the promoter

    <p>True</p> Signup and view all the answers

    All RNAs require post-transcriptional processing

    <p>True</p> Signup and view all the answers

    After RNA pol I transcribes, RNases cut the precursor into 3 rRNAs. These are then exported to the cytoplasm. Why?

    <p>Because ribosomes are in the cytoplasm</p> Signup and view all the answers

    Nucleotidyl transferase adds CCA to

    <p>3' end</p> Signup and view all the answers

    Only RNA polymerase ___ transcripts are capped

    <p>II</p> Signup and view all the answers

    Abnormal hemoglobin in severe β(beta)- thalassemia caused by

    <p>splice site mutation</p> Signup and view all the answers

    splicing removes ____

    <p>introns</p> Signup and view all the answers

    A 7-methylguanosine-triphosphate cap protects the

    <p>5' end of eukaryotic mRNAs</p> Signup and view all the answers

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