21 Questions
Which Topoisomerase requires energy?
Topoisomerase II
RNA synthesis is known as
Transcription
The purpose of single-strand DNA binding proteins like replication protein A is to
keep single strand template open
What polymerase replaces DNA polymerase alpha and replicates the leading strand?
Polymerase Epsilon
What polymerase replaces DNA polymerase alpha and replicates the lagging strand?
Polymerase Delta
Errors that escape proofreading are corrected by
Mismatch repair enzymes
Base Excision Repair removes ___
Abnormal bases
Each time a chromosome divides its telomere gets shorter. Short telomeres causes cellular _____
senescence
What solves the end replication problem
Telomerase
The promoter's function is the same in prokaryotes as it is in eukaryotes. That is it defines the Transcription Start Site, defines which DNA strand is the template, and the direction of transcription.
True
RNA Polymerase terminates RNA synthesis when the newly made RNA folds into a
hairpin
All three RNA polymerases (I,II,III) are sensitive and can be inhibited by
Actinomycin D
Rifampin, a first-line antibiotic against TB, is able to bind eukaryotic RNA polymerases.
False
The purpose of the Sigma factor is to help bacterial RNA polymerase recognize the promoter
True
All RNAs require post-transcriptional processing
True
After RNA pol I transcribes, RNases cut the precursor into 3 rRNAs. These are then exported to the cytoplasm. Why?
Because ribosomes are in the cytoplasm
Nucleotidyl transferase adds CCA to
3' end
Only RNA polymerase ___ transcripts are capped
II
Abnormal hemoglobin in severe β(beta)- thalassemia caused by
splice site mutation
splicing removes ____
introns
A 7-methylguanosine-triphosphate cap protects the
5' end of eukaryotic mRNAs
Lecture 9
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