Class Tests Q's

Characteristic(process) of drug metabolic conjugates usually include(s):

Grapefruit and grapefruit juice are thought to:

Concerning the cytochrome P450 superfamily:

A "base" is a substance capable of yielding a proton (H+).

____________is the study of how an individual’s genetic inheritance affects the body’s response to drugs.

Characteristic(s) of enantiomers

Competitive inhibition:

The EC50 refers to the drug concentration at which

Structure that has some activity against the chosen target, but not yet good enough to be the drug itself

A constituent of St. John's wort, hyperforin, is an activator of the PXR receptor (pregnane X receptor). As a result:

Typically, the magnitude of drug effects is thought proportional to the number of occupied receptors:

Tissue reservoirs can become sites for accumulation and slow release of drugs/toxins. Name two tissue reservoirs and examples of agents that may accumulate there.

Name the four types of drug receptors?

Example(s) of major plasma proteins important for drug binding

Characteristic processes of drug metabolic conjugates usually include:

Describe first order kinetics of drug elimination

The study of the time course of drug absorption, distribution, metabolism and excretion is called

The structural features directly responsible for activity

Which one(s) of the following statements concerning G protein Coupled Receptors (GCPRs) is/are correct?

Metabolites generated by phase I drug biotransformation may exhibit

Name two of the four broad categories of the genes used in pharmacogenomics

Individuals lacking CYP2D6 activity (poor metabolizers, PM) suffer from

SLC2A2 encodes the facilitated glucose transporter

Flavin-containing monooxygenases (FMOs) represent another group (superfamily) of phase I enzymes

Give examples of 2 Type A (augmented) adverse drug reactions (ADR)

Which of these anti-diabetic drugs works by increasing endogenous incretin (GLP-1, GIP) concentrations by inhibiting their degradation?

Bisphosphonate drugs are used to treat

A drug that specifically dilates veins will result in…

Which of the following inflammatory cells are found in excessive numbers in the lungs of asthma patients?

Salbutamol is a first line treatment option for asthma in the UK. Which receptor does this drug activate in the lungs of asthmatic patients?

Beta-blockers are used for the treatment of angina because they:

Which of these is NOT a drug used in the treatment of hyperthyroidism

Genital herpes simplex infection would be treated using

In two or three sentences detail the cell signalling processes that occur following binding of a glucocorticoid to its receptor

Psychomotor stimulant drugs such as amphetamines are used to treat which TWO disorders?

Which of these drugs is used to induce ovulation in treating fertility?

Theophylline can sometimes be used as an alternative treatment in the management of respiratory disorders. State two pharmacological actions of theophylline

Define the term preload

Which of these hormones are secreted by the posterior pituitary?

Describe the two main strategies that are used to limit incidence of serious adverse effects with gluccorticoid therapy in asthmatic patients

Disulfiram is used to treat alcoholism, what is its mechanism of action?

Patients taking glucocorticoids should be monitored for evidence of which of the following?

Which of the anti-rheumatoid drugs is a monoclonal antibody

Which of the following factors facilitates drugs diffusion fairly freely across the BBB (blood brain barrier )?

GABAB receptor is a

Which of these drugs is a COX-2 specific NSAID?

NANC mediators are important in the regulation of the respiratory system and progression towards asthma. What does the acronym NANC stand for, and name one stimulatory and one inhibitory NANC mediator

Which of these drugs would be used to treat gout?

Giving examples, what are the three types of diuretic drugs?

Which of these drugs is a selective serotonin re-uptake inhibitor (SSRI) antidepressant drug?

Which of the following classes of drugs are NOT available via the inhalation route for the treatment of asthma?

How is cardiac output calculated?

Capital of France (example flashcard)