Midazolam PDF - Drug Information
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Mesa Community College
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Summary
This document provides information about the drug midazolam, including its mechanisms of action, indications, and dosages. It covers both adult and pediatric dosages and administration routes. This is a useful reference for healthcare professionals.
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GENERIC NAME midazolam TRADE, BRAND, OR PROPRIETARY NAME • Versed® CLASSES • Benzodiazepine • Anticonvulsant • Sedative • Hypnotic STANDARD SUPPLY • Vial MECHANISMS OF ACTION • Produces sedation by acting on the limbic system, the thalamus, and hypothalamus • Binds to gamma-amino butyric acid (GAB...
GENERIC NAME midazolam TRADE, BRAND, OR PROPRIETARY NAME • Versed® CLASSES • Benzodiazepine • Anticonvulsant • Sedative • Hypnotic STANDARD SUPPLY • Vial MECHANISMS OF ACTION • Produces sedation by acting on the limbic system, the thalamus, and hypothalamus • Binds to gamma-amino butyric acid (GABA) benzodiazepine receptors in the brain • Raises the seizure threshold • Produces tranquilizing (antianxiety) effect on the central nervous system INDICATIONS • Seizure activity • Status epilepticus • Procedural sedation for intubation and cardioversion • Chemical restraint for agitated (excited) delirium CONTRAINDICATION • Known hypersensitivity to the drug ADVERSE REACTIONS/SIDE EFFECTS • Sedation • Transient amnesia • Respiratory depression • Respiratory arrest • Bradycardia • Hypotension • Dizziness • Blurred vision • Nausea • Vomiting MIDAZOLAM 1 ROUTES OF ADMINISTRATION • IV • IO • IM ONSETS OF ACTION • IV/IO: 2 to 5 minutes • IM: 15 to 30 minutes ADULT DOSAGES • Seizure IV/IO: 0.1 mg/kg • Maximum dosage: 4.0 mg • Seizure IM: 0.2 mg/kg • Maximum dosage: 10 mg • Procedural sedation IV/IO: 0.5 to 2.5 mg • Maximum dosage: 0.1 mg/kg • Chemical restraint IV/IO: 0.05 to 0.1 mg/kg • Chemical restraint IM: 0.1 to 0.15 mg/kg PEDIATRIC DOSAGES • Seizure IV/IO: 0.05 to 0.1 mg/kg • Seizure IM: 0.2 mg/kg • Maximum dosage: 10 mg • Procedural sedation IV/IO: 0.05 to 0.5 mg/kg • Maximum dosage 0.1 mg/kg SPECIAL CONSIDERATIONS • Consider decreased dosages for elderly patients and patients with liver and kidney disease due to slower metabolic function • The peak effect of IV/IO administration of the drug is 3 to 5 minutes • The duration of IV/IOI administration of the drug is less than 2 hours • The peak effect of IM administration of the drug is 30 to 60 minutes • The duration of IMI administration of the drug is 1 to 6 hours MIDAZOLAM 2
