Exam 3 PQ_4 PDF Immunology Past Paper

lecture 22 & 23 1. Match the type of hypersensitivity to each description given. You may use each answer once, more than once, or not at all. Some questions may have more than one correct answer. Mediated primarily by T cells Type IV Antihistamines are u...

lecture 22 & 23 1. Match the type of hypersensitivity to each description given. You may use each answer once, more than once, or not at all. Some questions may have more than one correct answer. Mediated primarily by T cells Type IV Antihistamines are used for some types of this hypersensitivity Type I Dermatitis is/are classically this type(s) of hypersensitivity Type I & Type IV Patients with this type of hypersensitivity have elevated serum IgE Type I Reactions are mediated by IgG or IgM antibodies Type II & III Drug-induced hemolytic anemia Type II Allergy shots may help alleviate these reactions Type I Tissue damage initiated by deposition of small immune complexes Type III An example of this type of hypersensitivity is serum sickness Type III Some forms diagnosed using a Coombs test Type II 2. The immediate phase of a Type I hypersensitivity reaction involves all but one of the following events. Which does NOT predominantly occur in the immediate phase? Dilation of small blood vessels Increased mucus production Contraction of non-vascular smooth muscle Extravasation of eosinophil (This would happen in the late phase of the reaction) Increased vascular permeability 3. Which of the following therapies is important for the treatment of systemic anaphylaxis, but would not be used to treat most other Type I hypersensitivity reactions? Antihistamines Mast cell stabilizers Corticosteroids Epinephrine (Epinephrine should be given immediately and rapidly for systemic anaphylaxis, but is not used to treat most other Type I hypersensitivities.) 4. Which of the following conditions is mediated by antibodies produced by TH2-stimulated B cells? Atopic urticarial (hives) ( Th2-stimulated B cells result in IgE production. This reaction is mediated by IgE) Erythroblastosis fetalis Transfusion reaction Contact dermatitis Serum sickness 5. An indirect ELISA is performed on serum from your patient that you suspect is experiencing allergic asthma. If the diagnosis is correct, the assay would reveal elevated levels of which antibody isotype? IgA IgG IgM IgD IgE (IgE is the antibody isotype mediating the immune response occurring in allergic asthma.) 6. The standard TB test to determine if a patient has tuberculosis is designed to test for which of the following immune responses? Mast cell degranulation Immune complex deposition Antibody-dependent cellular cytotoxicity Complement activation T cell-mediated inflammation (The TB test is assessing if the patient has memory T cells to tuberculosis, thus causing a T cell-mediated inflammatory reaction at the injection site.) 7. A mother brings in her 6-month-old daughter to Urgent Care after she notices a large red and swollen area on her arm. History reveals she received a DTaP booster at the same location a few days prior to this visit. Serum analysis reveals high levels of C3a and C3b. This localized reaction at the injection site is most likely an example of which hypersensitivity? Type I Type II Type III (This localized reaction is known as an Arthus reaction, and occurs when small immune complexes are formed that deposit at the site of injection.) Type IV 8. True or False: Food allergies cannot develop in patients with selective IgA deficiency. True False ( A deficiency in IgA does not affect the person's ability to produce IgE. IgE is the isotype that mediates true food allergies (Type I hypersensitivity responses). 9. A pharmaceutical company is developing a topical cytokine therapy for the treatment of poison ivy-mediated contact dermatitis. Assuming the drug is able to be absorbed through the skin, which of the following cytokines would most likely be effective at reducing the severity of poison ivy reactions? IL-2 IFN- TNF-α IL-10 ( IL-10 is an immunosuppressive cytokine, so this may help to reduce inflammation.)