Development of Digestive System PDF
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Katerina Grygarová
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Summary
These lecture notes cover the development of the digestive system, from the folding of the embryo to the formation of the gut tube and different parts like foregut, midgut, hindgut. The document also discusses rotations, inborn defects like atresia and stenosis of duodenum, and other related topics.
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Development of digestive system Structure of the seminar and necessary terms Module A, Course 2 MUDr. Katerina Grygarová What's on the program? Development of GIT 1. Folding of the embryo 2. Formation of a gut tube 3. Foregut 4. Midgut 5. Hindgut 6. Rotatio...
Development of digestive system Structure of the seminar and necessary terms Module A, Course 2 MUDr. Katerina Grygarová What's on the program? Development of GIT 1. Folding of the embryo 2. Formation of a gut tube 3. Foregut 4. Midgut 5. Hindgut 6. Rotation of the gut 7. Inborn defects Let's draw ! Folding of the embryo Trilaminar disc lateral folding craniocaudal folding What are the relations between ectoderm, endoderm and mesoderm? Formation of the gut tube Primitive gut 4th week oropharyngeal membrane cloacal membrane stomodeum proctodeum What is the origin of various layers of the wall of fully formed GI tube? Foregut stomodeum / mem. oropharyngea → proximal part of duodenum A: celiac trunk (except pharynx, and oesophagus, and RT) gl. submandibularis and sublingualis thyroid gland base for RT formation liver, gall bladder, anterior part of pancreas oesophagus, stomach proximal part of duodenum Midgut proximal part of duodenum - fl. coli sin. (CB point) A: Sup. mes. a. part of duodenum, small intestine, part of large intestine Hindgut fl. coli sin. (CB point) - linea pectinata A: Inf. mes. a. last part of GIT CAVE! + epithelium of urinary bladder and part of urethra! cloacal membrane / proctodeum – rupture at the end of 8th week Mesentery ? ventral mesentery dorsal mesentery Intraperitoneal ? Retroperitoneal? Secondary retroperitoneal? Location? ventral (mesentery) mesegastrium dorsal mesogastrium Intraperitoneal ? Retroperitoneal? Secondary retroperitoneal? Adventitia? Retroperitoneal organs Abdominal Ao 2nd, 3rd, 4th part of VCI duodenum Adrenal glands ascending colon Kidneys descending colon Ureter head and body of the Bladder pancreas Lower rectum Rotation of the foregut 90 degrees, clockwise Oesophagus: obliteration and re-canalasation Stomach: asymmetric Liver and spleen Dorsal Mesog: greater omentum Ventral Mesog: lesser omentum Rotation of the midgut Development of midgut 270 degrees combined, clockwise physiological herniation (W 6 -10 ) Inborn defects to know esophageal atresia atresia / stenosis of duodenum gastroschisis omphalocele Hirschprungs disease umbilical hernia Esophageal atresia Gastroschisis Omphalocele Umbilical hernia Inborn defects to know esophageal atresia atresia / stenosis of duodenum gastroschisis omphalocele Hirschprungs disease umbilical hernia
