Control of Gene Expression PDF
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University of Missouri, Columbia
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Summary
This document discusses the regulation of gene expression, focusing on the steps involved in eukaryotes and the different types of genes regulated. It examines how gene products are produced and regulated, including constitutive genes and regulated genes.
Full Transcript
Regulation of gene expression • DNA RNA = primary site of regulation (Transcription) • Steps regulated in eukaryotes to control when and which gene products produced: 1. modifications to access regions of DNA 2. posttranscriptional modifications 3. posttranslational modifications 3 Regulation...
Regulation of gene expression • DNA RNA = primary site of regulation (Transcription) • Steps regulated in eukaryotes to control when and which gene products produced: 1. modifications to access regions of DNA 2. posttranscriptional modifications 3. posttranslational modifications 3 Regulation of gene expression • Not all genes are tightly regulated • Constitutive genes = expressed at constant levels products required for basic cellular functions • “housekeeping genes” • i.e. ribosomes • • Regulated genes: • only expressed when needed • expressed in all cells or subset of cells • i.e. hepatocytes 4 Regulation of gene expression • All cells have the same DNA that codes for all genes • Gene regulation determines: 1. What gene product is made? How much product is made? 3. When gene product is made? 4. Where gene product is made? 2. 5
