Bilirubin Metabolism-12.pdf

haemolyticjaundice jaundice Pre-hepatic  Due to increase in RBCs breakdown Causes  The rate of RBCs lysis and bilirubin production more than ability of liver to convert it to the conjugated form  Occur in: Hemolytic anemia ( Thalassemia) hepato-cellular jaundice Post-hepatic obstructivejaundice...

haemolyticjaundice jaundice Pre-hepatic  Due to increase in RBCs breakdown Causes  The rate of RBCs lysis and bilirubin production more than ability of liver to convert it to the conjugated form  Occur in: Hemolytic anemia ( Thalassemia) hepato-cellular jaundice Post-hepatic obstructivejaundice jaundice Hepatic jaundice  Due to obstruction of bile duct which prevents passage of bilirubin into intestine. Blilirubin that is conjugated is not efficiently secreted into bile but leaks to blood (D.Bil. )  D.Bil will back to liver and then to circulation elevating its level in blood and urine. Occur in :  Occur in:  Due to liver cell damage  Conjugation of bilirubin decreased (ID.Bil. ).   Hepatitis (viral ,drug, alcoholic autoimmune, steatohepatits) Cirrhosis. Biliary stricture Cancer of the head of pancreas or gallbladder Bileduct stones Transfusion reaction Gilbert's disease Type of Bil. Conformational test ID.Bil > D.Bil reticulocyte, K+ ( High) CBC (low Hb), Haptoglobin (Low) D.Bil, ID.Bil, T.Bil all (High) D.Bil (High) ALT, AST (High) ALP, GGT ( High)