Week 2 - Pharmacokinetics PDF

Pharmacokinetics  Pharmacokinetics is the study of what the body does to a drug. It refers to the changing concentrations or amounts of a drug and its metabolites in blood, plasma, urine and other body tissues and fluids Absorption - Routes of Administration...

Pharmacokinetics  Pharmacokinetics is the study of what the body does to a drug. It refers to the changing concentrations or amounts of a drug and its metabolites in blood, plasma, urine and other body tissues and fluids Absorption - Routes of Administration Enteral: Oral Sublingual Rectal Parenteral: Intravenous Intramuscular Subcutaneous Transdermal Inhalation Epidural Intra-articular Topical The Henderson Hasselbalch equation is an approximate equation that shows the relationship between the pH or pOH of a solution and the pKa or pKb and the ratio of the concentrations of the dissociated chemical species. In order to use the equation, the acid dissociation constant must be known. Elimination (Clearance)  Kinetics of Drug Elimination Zero-order Kinetics First-order Kinetics The rate of elimination is constant In this case the t1/2 is constant and and independent of drug the rate of elimination depends on how much drug is present, being concentration. The t1/2 depends on higher at higher plasma drug the amount of drug given, and is concentrations. A constant fraction longer when more of the drug has of the drug is being eliminated in been administered. unit time. Most drugs are eliminated with Few drugs are eliminated this way. first-order kinetics. Parmacokinetics https://www.youtube.com/watch?v=NKV5iaUVBUI