NURS 3113 Pharmacology Lecture Notes PDF

NURS 3113 PHARMACOLOGY Ch 2: Pharmacologic Principles Ch 7: Over-the-Counter (OTC) Drugs and Herbal and Dietary Supplements Week 1 Class Objectives: › Understand the general concepts of pharmacology including pharmaceutics, pharmacokinetics, and pharmacodynamics (CO 4) ›...

NURS 3113 PHARMACOLOGY Ch 2: Pharmacologic Principles Ch 7: Over-the-Counter (OTC) Drugs and Herbal and Dietary Supplements Week 1 Class Objectives: › Understand the general concepts of pharmacology including pharmaceutics, pharmacokinetics, and pharmacodynamics (CO 4) › Demonstrate an understanding of the various drug dosage forms as related to drug therapy and the nursing implications (CO 3 & 5) › Explain the influences of the patient's age on the effects of drugs and drug responses (CO 2, 4, & 5) What even is Pharmacology?!?  Pharmaceutics Toxicology Pharmacokinetics Pharmacogenomics Pharmacology Pharmacodynamics Pharmacoeconomics Pharmacotherapeutics Pharmacognosy Pharmaceutics  Oral Drug Taken Broken down in GI tract Drug Molecules through GI Mucosa Drug transported to site via blood/lymph  Pharmacokinetics › Absorption › Distribution › Metabolism › Excretion  Absorptio ›nMovement of a drug from administration to the bloodstream for distribution › Bioavailability › First-pass Effect › Routes of Administration › Enteral › Parenteral › Topical  Case Study Scenario: A nurse is caring for 4 different 1.) Why were these specific routes patients with chest pain chosen? (angina), who are each being 2.) Which forms have an immediate treated with nitroglycerin. action? 3.) Why is this important in this scenario? Patient A: Patient B: Takes 6.5 mg Takes a transdermal 4.) Which patient will be affected most (Extended-release) patch that delivers by the first pass effect? Why? tablets PO 3 times 0.2 mg/hr daily 5.) What would happen if patient A Patient C: Patient D: chewed their nitro dose? What about Takes 0.4 mg (currently admitted to the hospital with severe heart failure patient C? sublingually as after myocardial infarction) needed for chest pain Receiving 15 mcg/min (angina) intravenous infusion Distributio n › Transportation of a drug via the bloodstream to the site of action › Extravascular Drug Movement › Drug-Drug Interaction › Blood Brain Barrier Metabolis m › Alteration of a drug into one of these four states: an inactive metabolite, a more soluble compound, a more potent active metabolite, or a less active metabolite › Liver › P-450 Excretion › Elimination of drugs from the body › Kidney › Excretion Process › Half-Life › Onset of Action › Peak › Duration › Trough  Pharmacodynamic s o Mechanism of Action o Interaction Types o Receptor o Enzyme o Nonselective  Pharmacotherapeuti cs oContraindication oTypes of therapies oMonitoring  CH 7: OVER-THE-COUNTERS & HERBAL/DIETARY SUPPLEMENTS  Safety with OTCs Concerns Education Communicatio n With PCP Herbal Supplements › Safety › Education QUESTIONS? ?