Unit-5 Reagents PDF

Unit-5 Reagents SPCHE03 M.Sc. Chemistry SPH NFSU The Grignard Reagent  The Grignard Reagent The Nobel Prize in Chemistry 1912 Discovered in 1900 in University of Lyon, France "for the discovery of the so-called Grignard reagent, which in recent years has greatly...

Unit-5 Reagents SPCHE03 M.Sc. Chemistry SPH NFSU The Grignard Reagent  The Grignard Reagent The Nobel Prize in Chemistry 1912 Discovered in 1900 in University of Lyon, France "for the discovery of the so-called Grignard reagent, which in recent years has greatly advanced the progress of organic chemistry" Victor Grignard  Discovered in 1900 in University of Lyon, France – Key factors are ethereal solvent and water-free conditions Awarded Nobel Prize in 1912 By 1975, over 40000 papers published using Grignard reagents – Mostly synthetic applications – Physical nature complicated Alkyl Grignards are most widely studied – Allyl and cyclic Grignard reagents will also be covered The Grignard Reagent  The Grignard Reagent X = Cl, Br, I R = methyl 1°, 2°, 3° alkyl vinyl alkynyl aryl  The Grignard Reagent X = Cl, Br, I R = methyl 1°, 2°, 3° alkyl vinyl alkynyl aryl  The Grignard Reagent +2 X = Cl, Br, I R = methyl 1°, 2°, 3° alkyl vinyl alkynyl aryl  The Grignard Reagent +2 -1 X = Cl, Br, I R = methyl 1°, 2°, 3° alkyl vinyl alkynyl aryl  The Grignard Reagent +2 -1 -1 X = Cl, Br, I R = methyl 1°, 2°, 3° alkyl vinyl alkynyl aryl  The Grignard Reagent X = Cl, Br, I R = methyl 1°, 2°, 3° alkyl vinyl alkynyl aryl  The Grignard Reagent X = Cl, Br, I R = methyl 1°, 2°, 3° alkyl vinyl alkynyl aryl  The Grignard Reagent X = Cl, Br, I R = methyl 1°, 2°, 3° alkyl vinyl alkynyl aryl  The Grignard Reagent X = Cl, Br, I R = methyl 1°, 2°, 3° alkyl vinyl alkynyl aryl  The Grignard Reagent X = Cl, Br, I R = methyl 1°, 2°, 3° alkyl vinyl alkynyl aryl The Grignard Reagent The Grignard Reagent The Grignard Reagent The Grignard Reagent The Gilman Reagent  Professor Henry Gilman (May 9, 1893 – Nov 7, 1986). Born in Boston, Massachusetts, he received his B. S. (1915), an M. S. (1916), and a Ph.D. (1918) in Chemistry from Harvard University. For his pre-doctoral work he studied in Europe at Zurich Polytechnikum, the Sorbonne in Paris, and at Oxford in London. Dr. Gilman began his career at the University of Illinois as an Instructor of Chemistry in 1919. Later that year, he accepted the position of Assistant Professor (1919 - 1920) at Iowa State College (University). By 1923 Dr. Gilman had been promoted to full Professor teaching all the Organic Chemistry courses at Iowa State College. His main area of research was in the Organometallic Chemistry area of Grignard reagents where he developed numerous Organometallic reagents, including the dialkyllithium reagent which bears his name. http://www.lib.iastate.edu/spcl/exhibits/150/template/gilman.html The Gilman Reagent The Gilman Reagent The Gilman Reagent The Gilman Reagent The Gilman Reagent DIBAL-H Applications of DIBAL-H  The Suzuzi – Miyaura Cross Coupling The Nobel Prize in Chemistry 2010 "for palladium-catalyzed cross couplings in organic synthesis" Richard F. Heck Ei-ichi Negishi Akira Suzuki The Suzuzi – Miyaura Cross Coupling Used in preparation of biaryls The Suzuzi – Miyaura Cross Coupling Used in preparation of biaryls The Suzuzi – Miyaura Cross Coupling Used in preparation of biaryls The Suzuzi – Miyaura Cross Coupling The Suzuzi – Miyaura Cross Coupling The Suzuzi – Miyaura Cross Coupling The Suzuzi – Miyaura Cross Coupling The Suzuzi – Miyaura Cross Coupling The Suzuzi – Miyaura Cross Coupling The Suzuzi – Miyaura Cross Coupling The Suzuzi – Miyaura Cross Coupling The Suzuzi – Miyaura Cross Coupling The Sonogashira Cross Coupling Used in preparation of arylalkynes The Sonogashira Cross Coupling Used in preparation of arylalkynes The Sonogashira Cross Coupling Used in preparation of arylalkynes The Sonogashira Cross Coupling Used in preparation of arylalkynes