Bone Tissue: Histology PDF
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Universidad Europea
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This document provides an outline and detailed information on bone tissue histology from Universidad Europea. It describes the different cell types involved in bone formation and maintenance and explains the process of bone formation and remodeling.
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OUTLINE 4.2 Bone tissue. 4.2.1. General characteristics of bone tissue. 4.2.2. Functions of bone tissue and skeletal system. 4.2.3. Types of bone. 4.2.4. Structure of the bone: parts of a long bone. 4.2.5. Histology of bone tissue. 4.2.6. Types of bone tissue. 4.2.7. Microscopic structure of bones....
OUTLINE 4.2 Bone tissue. 4.2.1. General characteristics of bone tissue. 4.2.2. Functions of bone tissue and skeletal system. 4.2.3. Types of bone. 4.2.4. Structure of the bone: parts of a long bone. 4.2.5. Histology of bone tissue. 4.2.6. Types of bone tissue. 4.2.7. Microscopic structure of bones. 4.2.8. Irrigation and innervation of bone tissue. 4.2.9. Bone formation. Osteogenesis. 4.2.10. Bone remodelling. © Copyright Universidad Europea. Todos los derechos reservados BONE TISSUE: HISTOLOGY J Builds up bones. CELLS BONE MATRIX + RESIDENT FIBRES -Osteogenic -Osteoblasts -Osteocytes - Collagen type I (25% of matrix) -Osteoclasts (phagocytic) © Copyright Universidad Europea. Todos los derechos reservados GROUND SUBSTANCE - Water (10%) - Salts - Proteoglycans - Hyaluronic acid CALCIFIED Osteoid matrix is the initial, non-calcified ground substance. 65% TYPES OF CELLS Bone cells derived from mesoderm (mesenchymal cells) • Osteoprogenitor or osteogenic cells (undifferentiated cells): – can divide to replace themselves & can become osteoblasts. – found in the inner layer of periosteum, in endosteum and in channels with blood vessels. • Osteoblasts: form matrix (non collagenous proteins such as the hormone osteocalcin, the glycoproteins sialoprotein I and II, osteonectin; enzymes such as alkaline phosphatase and collagenase; collagen type I fibres) but can’t divide. They start the calcification process. • Osteocytes: mature cells that no longer secrete matrix. They maintain bone tissue metabolism. Located in lacunae. Internal use TYPES OF CELLS Bone cells derived from mesoderm (mesenchymal cells) © Copyright Universidad Europea. Todos los derechos reservados TYPES OF CELLS Bone cells derived from white blood cell lineage. • Osteoclasts: giant multinucleated cells that derive from fused monocytes (macrophages). – Ruffled border: Important in bone resorption (breakdown of bone matrix). – They secrete lysosomal enzymes and acids to digest and reabsorb extracellular bone matrix (clear zone). © Copyright Universidad Europea. Todos los derechos reservados
