Drugs for Cardiac Failure PDF

Ibnisina university Faculty of medicine Drugs for Cardiac Failure 1.Match each drug used in cardiac failure with the appropriate description (each lettered option can be selected once, more...

Ibnisina university Faculty of medicine Drugs for Cardiac Failure 1.Match each drug used in cardiac failure with the appropriate description (each lettered option can be selected once, more than once, or not at all). A. Captopril ACEIs B. Digoxin To inhibition of Na \ K ATpase C. Dobutamine B1 Agonist D. Furosemide Loop Diuretics E. Losartan AngiontensinII receptor Inhibitor F. Milrinone Phospodiesterase Inhibitor G. Nesiritide Vasodilator H. Propranolol Non selective B blocker I. Spironolactone K sparing diuretics 1.This drug can cause peripheral vasodilation by blocking phosphodiesterase type 3 Milirinone 2. This drug can increase the synthesis of cyclic adenosine monophosphate (cAMP) in the heart. Dobutamine 3. The chronic use of this aldosterone antagonist can reduce mortality in patients with severe heart failure. Spironolactone 4. This drug can cause peripheral vasodilation by increasing the synthesis of cyclic guanosin monophosphate (cGMP). Nesiritide 5. This drug can increase central parasympathetic ring. Digoxin By Increase stimulating Vagal 2.Gaffer a 68-year-old recently diagnosed with stage C heart failure started a treatment with metoprolol, losartan, furosemide, and digoxin. Which of the following molecular actions most likely mediated the positive inotropic action of digoxin? A. Closing of calcium channels in cardiac cell membranes B. Increased release of Ca2+ from the sarcoplasmic reticulum during systole C. Activation of Na+/K+ ATPase D. Activation of the Ca2+/Na+ exchanger in cardiac cell membranes E. Opening of K+ channels in cardiac cell membranes 3.Adam a 63-year-old complained to his physician of nausea, vomiting, and a visual sensation of green-yellow halos around bright objects. The man, recently diagnosed with cardiac failure and atrial fibrillation, had started an appropriate treatment 2 weeks earlier. Which of the following drugs most likely caused the patient’s symptoms? A. Verapamil B. Propranolol C. Digoxin D. Lidocaine E. Furosemide F. Captopril 4.Safia a 68-year-old woman recently diagnosed with stage C heart failure started a treatment with digoxin. Knowing that digoxin has a clearance of about 7 L/h and an oral bioavailability of about 70%, which of the following doses (in milligrams) was most likely given to achieve a mean steady-state plasma concentration of 1 μg/L? ‫هنا نستخدم قانون المفروض اخذناه في الجينرال‬ Maintenance Dose = ( Css * cl * t ) \ F = (1 * 7 * 24 h) \ 0.7 = 240 μg = 240\1000= 0.24 milligrams/L ‫ ساعه جرعه لكن لست متاكد‬24 ‫المسئله لست متاكد من حلها بسبب عدد الجرعات فعلت خالل‬ A. 1.4 B. 0.125 C. 0.24 D. 2.0 E. 0.5 F. 2.4 5. Hamid a 73-year-old man complained to his physician of increasing fatigue and shortness of breath that was often worse at night, forcing him to “sit bolt upright.” He also not iced that his feet were getting swollen. Past history was unremarkable. Vital signs were blood pressure 150/90, respirations 17/min. On examination, mild pitting edema was seen on the legs. An electrocardiogram disclosed a second-degree atrioventricular block. His physician diagnosed initial cardiac failure and prescribed an appropriate therapy. Which of the following drugs would be contraindicated for this patient? A. Captopril B. Hydrochlorothiazide C. Digoxin D. Losartan E. Furosemide F. Spironolactone 6.Muna a 63-year-old recently diagnosed with systolic heart failure started a treatment with furosemide and captopril. Plasma levels of which of the following pairs of compounds were most likely increased after the administration of captopril? A. Vasopressin and sodium B. Norepinephrine and angiotensin II C. Bradykinin and angiotensin I D. Atrial natriuretic peptide and serotonin E. Angiotensin III and prostaglandins 7. Saeed a 54-year-old complained to his physician of an abnormal increase in the size of his breastsThe man had been suffering from systolic heart failure for 3 years. Two months earlier, the cardiologist had added a drug to the patient’s therapeutic regimen. Which of the following drugs most likely caused the patient’s symptom? A. Furosemide B. Losartan C. Carvedilol D. Spironolactone (due to spironolactone Anatgonize Mineralocoticoid Reveptor and also androgen and progesterone receptors) E. Indapamide (an abnormal increase in the size of his breasts(Man has Gynecomastia need to progesterone receptors ‫) للتوضيح‬