Tech Sheet_GlutatthioneComplex_01_V4web.pdf

LIPOSOMAL GLUTATHIONE COMPLEX THIS INFORMATION IS PROVIDED AS A MEDICAL AND SCIENTIFIC EDUCATIONAL RESOURCE FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS (“PRACTITIONERS”). THIS INFORMATION IS INTENDED...

LIPOSOMAL GLUTATHIONE COMPLEX THIS INFORMATION IS PROVIDED AS A MEDICAL AND SCIENTIFIC EDUCATIONAL RESOURCE FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS (“PRACTITIONERS”). THIS INFORMATION IS INTENDED FOR PRACTITIONERS TO USE AS A BASIS FOR DETERMINING WHETHER TO RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. ALL RECOMMENDATIONS REGARDING PROTOCOLS, DOSING, PRESCRIBING AND/OR USAGE INSTRUCTIONS SHOULD BE TAILORED TO THE INDIVIDUAL NEEDS OF THE PATIENT CONSIDERING THEIR MEDICAL HISTORY AND CONCOMITANT THERAPIES. THE DIETARY SUPPLEMENTS OFFERED BY QUICKSILVER SCIENTIFIC ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT, DIAGNOSE, OR MITIGATE ANY DIESEASE OR OTHER MEDICAL CONDITION. Glutathione Complex is an advanced liposomal formula that blends glutathione, the body’s master antioxidant, with B complex vitamins, trimethylglycine (TMG), and milk thistle seed extract for optimal support of high-level detoxification. EDUCATION GLUTATHIONE SUPPORTS ALL THREE PHASES OF DETOXIFICATION Glutathione is present in every single cell of our bodies— at surprisingly high levels equal to that of glucose, potassium or cholesterol.1 Concentrations are five to ten times higher in hepatocytes than other cells as the liver is constantly processing and removing toxins.2 Glutathione offers comprehensive, broad spectrum antioxidant protection3, binding to a wide array of damaging molecules, including reactive oxygen species (ROS), lipid peroxides, xenobiotics, pesticides, mycotoxins, oxidized vitamin E, oxidized vitamin C, methylmercury, medications, heavy metals, and other harmful substances. Glutathione also provides potent protection inside the mitochondria, our cells’ energy powerhouses; is critical to our immune system function, helps dampen inflammation; is a key player in autoimmunity; and may confer protection from cancer, heart disease, and Alzheimer’s disease.4,5,6,7,8 Strengthening the glutathione system supports all three phases of detoxification, but in particular phases II and III.9 Phase I - Oxidation: The liver converts a lipid-soluble toxin into a less harmful compound, preparing it for phase II detoxification. This occurs through oxidation, reduction and hydrolysis of substances via cytochrome P450 enzymes. Phase II—Conjugation: Glutathione binds to the toxin, rendering it water soluble. This occurs through sulfation, glucuronidation, and glutathione conjugation of toxins. Phase III—Elimination: Cellular transport and elimination of the conjugated substances through bile or urine. Optimal phase II and III detoxification requires the activation of the cellular master switch Nrf2.10 Nrf2 regulates over 500 genes involved in detoxification. GLUTATHIONE EXERTS POTENT ANTI-INFLAMMATORY ACTION AND AUTOIMMUNE SUPPORT Glutathione is integral to the proper function of our immune system. Altered intracellular levels of reduced glutathione (GSH) have been seen in infections and autoimmune disease, along with immune activation and inflammation.11 The two arms of the immune system, TH1 and TH2, are regulated by intracellular glutathione levels, and even a modest increase in intracellular glutathione (GSH) and glutathione disulfide (GSSG) levels potentiates the immune action of lymphocytes.12,13 Reduced levels of GSH have been linked with lupus, rheumatoid arthritis, autoimmune thyroiditis, cataracts, and aging.14,15,16,17,18,19,20,21 Supplementing glutathione improves markers of immune function.22 GLUTATHIONE CONJUGATES AND ELIMINATES MYCOTOXINS, METHYLMERCURY AND OTHER NEUROTOXINS Glutathione plays an essential role in defending us from mercury toxicity. Mercury is a potent biological toxin that is present in auto pollution, fish, dental amalgam, vaccines, and contaminated air and water. Glutathione targets and binds methylmercury and prevents it from penetrating the cell, thereby reducing inflammation and protecting against oxidative damage.23 Glutathione is also critical in conjugating and eliminating other heavy metals, such as arsenic.24 Chronic exposure to mycotoxins from mold can decrease levels of the enzymes needed to form glutathione, leading to compromised glutathione production and tissue damage or systemic illness.25 Liposomal glutathione has been reported to be beneficial in the management of mycotoxin-related conditions.26 GLUTATHIONE PROTECTS THE HEART AND BRAIN Glutathione is the most abundant antioxidant in the heart. Lowered levels play an important role in the development of cardiovascular diseases, and have been found in patients with coronary artery disease.27 Depressed GSH synthesis can lead to atherogenesis (fatty plaques) and is also associated with hypertension.28 In contrast, an increased level of GSH is correlated with lower blood pressure and a decreased incidence of diabetes.29 In addition, glutathione is a key antioxidant for the mitochondria, which are more abundant in heart muscle than any other tissue in the body.7 Just as glutathione protects the heart, it can be neuroprotective and help support brain function. Neurodegenerative diseases are linked to increased mitochondrial oxidative stress, and lowered levels of mitochondrial glutathione.30 The increased oxidative stress noted in Alzheimer’s disease and mild cognitive impairment has been attributed to lowered levels of glutathione in the brain.31,32 MILK THISTLE AND BETAINE SUPPORT LIVER FUNCTION & DETOXIFICATION Disturbances in glutathione homeostasis correlate with liver diseases induced by drugs, alcohol, diet and environmental toxins. Not surprisingly, glutathione is present in high levels in the liver.33 Milk thistle (Silybum marianum) has been used as an herbal remedy for 2000 years, in particular for treatment of hepatobiliary diseases.34 Milk thistle contains three potent flavonolignans together known as silymarin. Silymarin can prevent the absorption of harmful compounds into the liver’s hepatocytes and may protect against liver injury due to chemical and environmental compounds. It has a beneficial effect on bile flow and novel anticholestatic properties.35 Laboratory and animal studies show that silymarin boosts glutathione levels.36,37 Betaine is synthesized in the liver and kidney, where it is abundant, and supports both liver and kidney function.38,39 Betaine has been shown to improve conditions ranging from diabetes to obesity and Alzheimer’s disease.40 Betaine is widely found in foods and is well tolerated in supplement form.41 B VITAMINS FUEL CELLULAR METABOLISM B vitamins are critical to overall health and wellbeing. They serve as cofactors for enzymatic reactions, and are necessary for gene expression, oxidation and reduction, energy metabolism, methylation, DNA repair, immune function, detoxification, and mitochondrial function.42 Our B-Complex includes the active form of B2 (riboflavin 5’-phosphate), B6 (pyridoxine hydrochloride), folate (as folinic acid), and MethylB12, as well as B1, B3, B5 and biotin. These provide the building blocks for healthy, balanced methylation and detoxification.43 Quicksilver Delivery Systems® improve upon liposomal and emulsification technology with smaller, more stable particles made from the highest-grade ingredients available. In addition to exceptional absorption rates, these tiny liposomal and nanoemulsified particles increase diffusion across mucus membranes, enhance lymphatic circulation of nutrients and support cellular delivery. ® TS220010 Rev. 01 References available at quicksilverscientific.com/glutathionecomplexreferences/