TE Quiz#3 2024 Key PDF

Quiz #3 1. An adaptive/cell-mediated immune response to an implanted material/device always indicates a failure of the implant. A) True B) False 2. A study is exploring the impacts of a drug on early wound healing processes. Experimental data from administration of this drug at the ti...

Quiz #3 1. An adaptive/cell-mediated immune response to an implanted material/device always indicates a failure of the implant. A) True B) False 2. A study is exploring the impacts of a drug on early wound healing processes. Experimental data from administration of this drug at the time of skin wounding shows that fibrin clot formation is significantly impaired. What is the drug most likely doing that explains this data? A) Blocking vasoconstriction B) Blocking monocyte differentiation C) Blocking Factor X activation and activity D) All of the above 3. A surgeon has resected a cancerous tumor from a tissue and needs a histological analysis rapidly to determine if all of the cancerous tissue has been removed and the surgery can be completed, or if the surgery needs to continue because further resection is needed. What tissue fixation method is best for this scenario? A) Fresh B) Fixed C) H&E D) Immunostaining 4. You want to visualize the laminin distribution on a new biomaterial you have developed; which special histological stain would be most useful for this purpose? A) Collagen antibody staining B) Von Kossa C) PAS D) All of the above E) None of the above 5. Nidus formation is not a concern for implanted biomaterials. A) True B) False 1 6. You are trying to specifically detect/stain for a protein that is present in very low levels in you tissue of interest. What method is best for this scenario? A) Routine staining B) Antibody staining C) Indirect immunostaining D) Direct immunostaining 7. You have been working to engineer bone tissue and want to image the distribution of collagen in the tissue. What special stain is best for this analysis? A) Trichrome B) Von Kossa C) Alcian Blue D) H&E 8. Which of the following is most important for visualizing features/regions of interest in a histologic tissue section? A) Magnification B) Resolution C) Tissue type D) None of the above 9. In the context of wounds, macrophages: A) Secrete growth factors/cytokines B) Manage the wound bed environment C) Activate other wound bed cells D) Differentiate from monocytes E) All of the above 10. The Vroman Effect describes the _____ composition on biomaterial _____ as they evolve over _____ when exposed to a complex medium such as blood. A) protein, surfaces, time B) nucleic acid, membranes, distance C) cellular scaffold, time D) All of the above E) None of the above 2