Renal Physiology I: GFR (PDF)
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This document provides information on renal physiology, focusing specifically on glomerular filtration rate (GFR). It defines terms like renal blood flow and renal plasma flow, and explains how GFR is measured. The information in this PDF is about kidney function.
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07/01/24 Renal physiology I: GFR Learning objective: de ne and describe auto regulation of renal blood ow. Learning objective: de ne what is glomerular ltration rate and how it is regulated. Definitions: RBF- Renal Blood Flow. The volume of blood delivered to the kidneys per unit time. RPF- Renal Pl...
07/01/24 Renal physiology I: GFR Learning objective: de ne and describe auto regulation of renal blood ow. Learning objective: de ne what is glomerular ltration rate and how it is regulated. Definitions: RBF- Renal Blood Flow. The volume of blood delivered to the kidneys per unit time. RPF- Renal Plasma Flow. The volume of plasma delivered to the kidneys per unit time. GFR- Glomerular Filtration Rate. How much uid is squeezed through the glomerular bed per unit time. FF- Filtration Fraction. GFR/RPF x100. RPC- Renal Plasma Clearance. The volume of plasma that is cleared of a known substance per unit time. Because your plasma makes up 55% of your blood, your RPF is 55% of your RBF. How to measure GFR: We need to use a substance that can: Be ltered freely ( smaller than 30000 Daltons ). Not secreted or reabsorbed. Not toxic. Not broken down/ metabolised. GFR UX p V U= solute concentration in the urine. V= volume of urine excreted per minute. P= solute concentration in the plasma. Inulin is the only substance, where GFR and renal clearance are the same value. Because of its complexity, it cannot be used routinely. Overview:
