Question and Answer PDF

Name: Kaing Sivling 1. They are sterile preparations intended to be injected or implanted in the human or animal body. This is the definition of: D. Preparations for parenteral use 7 How to remove precipitates, crystals, fibers from injectable solutions? A. By clarifying filtration using the 0.22...

Name: Kaing Sivling 1. They are sterile preparations intended to be injected or implanted in the human or animal body. This is the definition of: D. Preparations for parenteral use 7 How to remove precipitates, crystals, fibers from injectable solutions? A. By clarifying filtration using the 0.22 μm millipore filter 8 What is the pH range of body fluids? D. 7.35 to 7.45 9 At what pH is the prep. Inj ? A. Do not get away from neutrality 10 What conditions the pH? A. Tolerance by the body 11 We want to make an injectable preparation. How to solve the pH problem, if the API is only stable at pH about 3? B. Acidify with hydrochloric acid 12 We wants to make an injectable preparation. How to solve the pH problem, if the pH is only stable at pH 5-6? A. Buffered with pH buffer about 5-6 13 One wants to make an injectable preparation. How to solve the problem if the solution of the active ingredient is unstable at any pH? A. Present the active substance in sterile powder to be dissolved at the time of use 14. Of the two buffered and unbuffered injectable solutions, which causes pain for longer? Why? B. Buffered injectable solutions. There is competition of drug buffer and tampons of the body. 16. When to control the pH of injections? D. Before and after sterilization 17. What is isotonic solution in relation to the erythrocytes? D. Solution that does not swell or curl erythrocytes. 18. What is the concentration of NaCl, in%, in an isotonic solution? C. 0,9% 19. What is the concentration of glucose, in%, in an isotonic solution? D. 5% 20. Hemolysis appears from what concentration of NaCl? B. 0,48 % 21. They are aqueous liquid preparations containing a high proportion of sugar which gives them their consistency and ensures their preservation under certain conditions. This is the definition of: B. Syrup 23. What is the amount of sugar per 1000 g of water to prepare the cold simple syrup? C. 1800 g 24. What is the amount of sugar per 1000 g of water to prepare the hot single syrup in a closed container? C. 1800 g 25. What is the amount of sugar per 1000 g of water to prepare the hot single syrup in an open container? B. 1650 g 26. Why do we use more cold sugar than hot open container? A. Evaporation of steam during heating 27. What is the boiling point of the syrup? D. 105°C 28. What is the density of the syrup at 25 ° C? D. 1,32 29. What is the density of the syrup at the boil? C. 1,26 31. Are solid consistency preparations each containing a dosage unit of one or more active substances and are obtained by compressively agglomerating a constant volume by copression of particles. This is the definition of: D. Tablet 37. To bond together the particles which can not be under the action of pressure alone. It is owned by: B. Binder 38. Filling when the amount of active ingredient is insufficient to make a tablet of suitable size. It is owned by: C. Diluent 40. When do we put the lubricants? C. At the beginning of dry mixing 41. What causes excess lubricant? C. Tablet friability 42. Shorten the disintegration time of the tablets. It is owned by: D. Disintegrating 43. The disintegrant prorpiety is: B. Accelerate disintegration of tablets 45. A product used as a wetting agent in tablets is: B. Sodium Lauryl Sulfate 49. What is the role of flavoring in the production of tablets? B. Mitigating the unpleasant flavors / odors of active ingredients 51. What is the role of adsorbent or absorbent? D. Retain certain volatile principles 56. What is the purpose of granulation in the manufacture of tablets? B. To increase the powder density 57. The granulation is done in a? D. Granulator 60. What is the shape of a die (matrice)? B. Hole drilled cylinder 61. What is the shape of a punch? C. Nail-shaped 62. What is the shape of hopper and hoof? D. J-shaped 63. What is the shape of the hopper? A. Funnel-shaped 64. What is the fixed part in the alternative machine? A. Die (Matrice) 65. What is the role of the die (matrice) in the alternative machine? B. Retain grain during compression 66. What is the role of hopper and hoof in the alternate machine? C. Feeding grain 67. What is the role of the upper punches in the alternative machine? A. Compress 70. What is the position of the lower punch when feeding into the reciprocating machine? B. In low position 71. What is the position of the upper punch when feeding into the reciprocating machine? A. Is raised 72. What is the position of hopper and hoof when feeding into the alternative machine? D. Above the compression chamber 73. What is the position of the lower punch at the time of shaving in the reciprocating machine? B. In low position 74. What is the position of the upper punch at the time of shaving in the reciprocating machine? A. Is raised 75. What is the position of hopper and hoof at the time of shaving in the alternative machine? D. Moves horizontally by flaring the powder to the upper level of the die (matrice) 76. What is the position of hopper and hoof at the moment of ejection in the alternative machine? D. Moving horizontally to feed the matrix, pushes the tablet out 77. How to adjust the alternate machine to increase the average weight of the tablets? C. Lower the lower punch 78. How to adjust the alternate machine, to increase the hardness of the tablets? B. Lower the upper punch 79. What is the fixed part in the rotary machine? A. Hopper and hoof 80. Individually weigh 20 tablets; Calculate AW: AW = (W1+W2+...+W20)/20; At least 18 tablets belong to [AW±e] and at most 2 tablets belong to [AW-2e; AW-e] U [AW+e; AW+2e]. It is the control of: A. Uniformity of weight 81. Are aqueous or oily sterile solutions or suspensions containing one or more medicinal substances intended for ocular instillation. This is the definition of: A. Eye drops 83. How to solve the pH problem of eye drops, in general? B. A pH between the limits of stability of the API and the tolerance of the eye must be chosen, on the other hand 84. How to solve the pH problem of an eye drops, in case impossible? C. Show sterile powdered eye drops to be dissolved at the time of use 85. How to solve the pH problem of an eye drops if the active principle is stable outside neutrality? A. Adjust with acids or bases 86. What are the buffers used for eye drops? D. B and C (Boric buffer and Phosphoric buffer) 87. At what concentration of NaCl is the osmotic pressure of the tear? B. 0.9% NaCl 88. In what limit of osmotic pressure can it support the healthy eye? B. 0.5 to 1.5% NaCl 89. In what limit of osmotic pressure can it support the pathological eye? B. About 0.9% NaCl 90. By means of which substance the osmotic pressure of eye-drops in general is adjusted? C. NaCl 91. They are preparations of semi-solid consistency intended to be applied to the skin or to certain mucous membranes in order to exert a local action or to achieve the percutaneous penetration of medicinal principles. This is the definition of: D. SSPCA (Semi-Solid Preparation for Cutaneous Application) 92. What is the principle of preparation of hydrophobic ointments? A. Dissolve or disperse one or more API in hydrophobic (lipophilic) excipients. 93. Can absorb large quantities of water. It is owned by: B. Water-absorbing ointments 94. Vaseline, liquid paraffin, vegetable oils or animal fats, synthetic glycerides, waxes and liquid polyalkylsiloxanes are: A. Hydrophobic excipients of ointments 95. Semi-solid preparations for multi-phase skin application (lipophilic and aqueous). This is the definition of: B. Cream 96. Sodium or triethanolamine soaps, sulfated fatty alcohols, polysorbates in combination optionally with other water-in-oil emulsifiers. Those are : D. Emulsifying agents type L / H 99. They are semi-solid preparations consisting of liquids gelled with the aid of the appropriate gelling agents. This is the definition of: C. Gel 100. What is the principle of preparation of hydrophobic gels? D. Dissolve or disperse one or more p.a. in hydrophobic gelling agents. 101. What is the principle of preparation of hydrophilic gels? B. Dissolve or disperse one or more p.a. in the hydrophilic excipients and then gelled by the hydrophilic gelling agents 108. How does the PSSAC affect the passage of medication through the skin? B. The pH of the PSSAC can influence the degree of ionization of the ionizable active ingredients and thus their penetration 111. For the manufacture of PSSACs, why should we knead until complete cooling? C. To avoid the separation of excipients 112. In the preparation of the emulsions, how to introduce the? C. Mix the oily and aqueous phases at the specified temperature 113. How to check homogeneity of PSSAC? A. Macroscopically, by thin-layer spreading on a flat surface using a spatula. 114. With what aid is the hardness of the ointments measured? D. Penetrometer 115. What does the penetrometer display directly indicate? D. The hardness of PSSAC 116. Are preparations of solid consistency that are fusible, dispersible or soluble in the anal mucosa, each containing a unit for taking one or more active substances intended to be slipped into the anus. The mass of a suppository is 1 g to 3 g. This is the definition of: B. Suppository 118. Causes the awakening of a defecation reflex caused by the presence of a foreign body in the rectum. For example, glycerin attracts water into the rectal bulb and triggers the peristaltic movements causing the laxative effect. It's' : A. Mechanical action 119. Causes anti-hemorrhoidal or antiparasitic action. It's': B. Local Action 120. The active principle must pass into the general circulation. It's': C. Systemic action 122. How is the merger of cocoa butter? A. Soften at 30 ° C and melt at 36 ° C 123. How is the solidified glycerin fusion? D. Melt at 37 ° C while soluble in water 124. Problem: What is the mass of cocoa butter to be used to prepare 10 suppo of 0.1 g phenobarbital, given that its displacement factor is 0.62. 1 cocoa butter suppo weighs 3 g? The formula M = F - (f × S) is used. What is the value of M? C. M = 29.38 g 125. They are soft capsules of slightly elongated shape. They contain an active principle dispersed in a pasty or liquid excipient, often an oil added an emulsifier to facilitate diffusion into the rectal ampule. This is the definition of: C. Rectal Capsule 126. Are medicines of ovoid form of solid consistency, intended to be introduced to the bottom of the sexual cavity of the woman, on the neck of the uterus. This is the definition of: B. Ovule 127. The common method is to melt the excipient at the lowest temperature and then incorporate the finely powdered active ingredients. Pour the mass into the molds. Cool. Scrape. And cool down. This is the method of: B. Ovules 128. How to pack ovules? B. PVC / Alu Blisters 129. What is the standard of disintegration of ovule? D. 60 min 130. What is the standard of disintegration of gynecological tablets? B. 30 min 132. These are liquids intended to wash the throat. This is the definition of: A. Gargarisms 133. They are liquids intended to be applied by brushing or spraying on the mucous membranes of the oral cavity and the back of the throat in order to exert local action. This is the definition of: B. Collutoires 134. They are liquids, semisolids or solids administered in the nasal cavities for local or systemic action. This is the definition of: C. Nasal preparations 135. Nasal drop, nasal spray, nasal powder, nasal ointments, nasal wash solution. Those are : C. Nasal preparations 136. These are liquids or solids intended for use in the lower parts of the respiratory tract for local or systemic action. This is the definition of: D. Inhalation preparations 137. Solutions, emulsions, suspensions, powders, tablets or capsules for use in the lower parts of the respiratory tract. Those are: D. Inhalation preparations 140. These are the pharmacodynamic groups that can be administered by air. A proposal is false, which one? A. Antihistamines 142. What is the consequence of the abuse of vaso-constrictor use by air? C. Drug Rhinitis 144. What is the size of particles that can penetrate the Larynx? D. > 30 μ 145. What is the size of particles that can penetrate the nasal cavity? D. > 30 μ 146. Liquid, semi-solid preparations or powders intended for instillation, spraying, insufflation, application in the ear canal or atrial washing. This is the definition of: A. Auricular Preparations 148. What should be taken into account for atrial administration? B. The state of the tympanum