PPY400 Unit 2 Inflammation and Immune Pathology PDF

PPY 400: Unit 2 *Inflammation and Immune Pathology * Pain Chapters 5, 6, 4 Immune System Recall the structures of the immune system: 1. Skin and mucous membranes 2. Monocytes and macrophages 3. Lymphoid system (spleen, thymus gland, lymph nodes) 4. Bone marrow *WBCs or leukocytes...

PPY 400: Unit 2 *Inflammation and Immune Pathology * Pain Chapters 5, 6, 4 Immune System Recall the structures of the immune system: 1. Skin and mucous membranes 2. Monocytes and macrophages 3. Lymphoid system (spleen, thymus gland, lymph nodes) 4. Bone marrow *WBCs or leukocytes in the immune system to mediate inflammation and immunity. Remember, leukocytes locate and eliminate pathogens and foreign molecules Immune System continued The immune system is usually categorized into two defense types: 1. Innate – no previous exposure to pathogen/antigen; natural killer (NK) cells and phagocytic cells (neutrophils and macrophages) are able to respond to infection by a variety of antigens 2. Specific – more effective on 2nd exposure to an antigen; recognize specific antigens; B cells and T cells responsible for this type of immunity Review these defense systems and immune system structure using your text book Inflammation Inflammation occurs when cells are injured no matter the cause; protective mechanism and begins healing process Purpose of Inflammation: 1. To neutralize/destroy harmful invading agents 2. To limit the spread of harmful agents to other organs 3. To prepare damaged tissue for repair Signs of Inflammation 1. Redness 2. Swelling 3. Heat 4. Pain 5. Loss of function “-itis” is used to describe inflammation ex. Tendonitis, appendicitis etc. *Infection is usually accompanied by inflammation; but inflammation is not always caused by infection Inflammation Inflammation can be caused by exogenous sources (surgery, trauma, burns etc) or endogenous sources (ex. tissue ischemia from MI) Acute inflammation is short in duration, lasts