Pharmacotherapy in Obesity PDF

‫بسم هللا الرحمن الرحیم‬ ‫‪03.12.2024‬‬ ‫‪Hamed Mohammadi‬‬ ‫‪1‬‬  Tehran University of Medical Sciences School of Nutrition and Dietetics Pharmacotherapy in Obesity Dr. Hamed Mohammadi...

‫بسم هللا الرحمن الرحیم‬ ‫‪03.12.2024‬‬ ‫‪Hamed Mohammadi‬‬ ‫‪1‬‬  Tehran University of Medical Sciences School of Nutrition and Dietetics Pharmacotherapy in Obesity Dr. Hamed Mohammadi Assistant Professor Department of Clinical nutrition School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences 03.12.2024 Hamed Mohammadi 2  nadir of the curve was observed at BMI 23-24 among never smokers, 22-23 among healthy never smokers, and 20-22 with longer durations of follow-up. 03.12.2024 Hamed Mohammadi 3 03.12.2024 Hamed Mohammadi 4 03.12.2024 Hamed Mohammadi 5  FDA-Approved Medications for Weight management Today, nine FDA-approved AOMs remain on the market, with six approved for long-term weight loss, of which one is indicated for specific monogenic obesity mutations, and one “device” that functions as a medication. 03.12.2024 Hamed Mohammadi 6  *Short-term use is generally accepted as 3 months 03.12.2024 Hamed Mohammadi 7 03.12.2024 Hamed Mohammadi 8 03.12.2024 Hamed Mohammadi 9 03.12.2024 Hamed Mohammadi 10 03.12.2024 Hamed Mohammadi 11 03.12.2024 Hamed Mohammadi 12 03.12.2024 Hamed Mohammadi 13 03.12.2024 Hamed Mohammadi 14 03.12.2024 Hamed Mohammadi 15 03.12.2024 Hamed Mohammadi 16 03.12.2024 Hamed Mohammadi 17 03.12.2024 Hamed Mohammadi 18 03.12.2024 Hamed Mohammadi 19 03.12.2024 Hamed Mohammadi 20 03.12.2024 Hamed Mohammadi 21 03.12.2024 Hamed Mohammadi 22 03.12.2024 Hamed Mohammadi 23 03.12.2024 Hamed Mohammadi 24 03.12.2024 Hamed Mohammadi 25 03.12.2024 Hamed Mohammadi 26 03.12.2024 Hamed Mohammadi 27  What is IMCIVREE™ (setmelanotide)? ✓Proopiomelanocortin (POMC) –The neuron system that causes weight-loss. If you are deficient in POMC, it can affect your inability to lose weight. ✓Proprotein convertase subtilisin/kexin type 1 (PCSK1) – Disrupts the regulation of glucose homeostasis and food intake. ✓Leptin receptor (LEPR) deficiency – Causes constant hunger and quick weight gain leading to obesity. ✓These conditions occur when both copies of the relevant gene (one inherited from the mother and one from the father) have a specific change, or variant. 03.12.2024 Hamed Mohammadi 28  What is IMCIVREE™ (setmelanotide)? We all have pathways that are responsible for carrying messages between the brain and the body. One of these pathways signals to the body when to eat and when to stop eating, and helps regulate metabolism. Changes in the POMC, PCSK1, and LEPR genes can “block” this pathway, stopping these messages from getting through. Symptoms of POMC, PCSK1, or LEPR deficiency, include severe obesity early in life and intense hunger. IMCIVREE™ is the first-ever FDA-approved therapy for obesity due to these conditions. 03.12.2024 Hamed Mohammadi 29  The Usage of IMCIVREE™ IMCIVREE™ should not be used in people with obesity due to suspected POMC, PCSK1, or LEPR deficiency not confirmed by genetic testing (benign or likely benign result), or other types of obesity not related to POMC, PCSK1, or LEPR deficiency, including obesity associated with other genetic conditions and general obesity. 03.12.2024 Hamed Mohammadi 30  Why Would I Need IMCIVREE™ (setmelanotide)? People living with obesity due to POMC, PCSK1 or LEPR deficiency struggle with: ✓ Extreme, insatiable hunger all the time ✓ Focusing on anything else except for hunger Insatiable hunger, or hyperphagia, is not the same as regular hunger. It is a deep hunger that feels like the body is always in need of food. Children, from early infancy up to the age of 10, may gain far more weight than would be expected for their age. IMCIVREE™ helps activate the areas in the brain that control appetite, feeling full, and metabolism to help lose weight and keep it off. 03.12.2024 Hamed Mohammadi 31  Side Effects of IMCIVREE™ Problems with male and female sexual function Depression and suicidal thoughts or actions Increased skin pigmentation Darkening of skin lesions (moles or nevi) that a patient already has Benzyl alcohol toxicity 03.12.2024 Hamed Mohammadi 32 Common side effects of IMCIVREE™ Injection site reactions Darkening of the skin Nausea Headache Diarrhea Abdominal pain Back pain Fatigue Vomiting Depression Upper respiratory tract infections Erections that happen without any sexual activity in males 03.12.2024 Hamed Mohammadi 33 03.12.2024 Hamed Mohammadi 34 03.12.2024 Hamed Mohammadi 35 03.12.2024 Hamed Mohammadi 36 03.12.2024 Hamed Mohammadi 37 03.12.2024 Hamed Mohammadi 38 03.12.2024 Hamed Mohammadi 39 03.12.2024 Hamed Mohammadi 40