Amines PDF

# Chapter 09: Amines  ## Topic 1: Introduction 1. Amines are derived from ammonia molecule by replacing one or more hydrogen atoms with **alkyl group(s) only** and **proteins/vitamins/carbohydrates/fats**. 2. In nature, amines are found in **proteins** and **vitamins**. 3. Synthetic exam...

# Chapter 09: Amines  ## Topic 1: Introduction 1. Amines are derived from ammonia molecule by replacing one or more hydrogen atoms with **alkyl group(s) only** and **proteins/vitamins/carbohydrates/fats**. 2. In nature, amines are found in **proteins** and **vitamins**. 3. Synthetic example of amine containing substances are alkaloids and hormones. 4. **True** * Adrenaline and ephedrine are biologically active compounds containing amino group. * Both adrenaline and ephedrine are used to decrease/reduce the blood pressure. 5. | Column I (Compound) | Column II (Uses) | | ------------------------ | ------------------- | | Novocain | Anaesthetic (dentistry) | | Benadryl | Antihistaminic drug | | Quaternary ammonium salt | Surfactants | | Diazonium salt | Preparation of dyes | ## Topic 2: Classification & Structure of Amines 6. CH3-NH-CH3 7. **pyramidal** and the nitrogen orbitals are **sp³** hybridised. 8. (C2H5)2CHNH2 9. A: Primary amine, B: Secondary amine 10. Both I and II 11. different alkyl or aryl groups ## Topic 3: Nomenclature 12. Methanamine 13. **di** and **tri** prefixes before the name of **alkyl** group respectively. 14. **False** 15. Aniline 16. **amine**  17. | Column I (Structure) | Column II (Name) | | ------------------------ | ------------------- | | | 4-bromoaniline | | | N, N-dimethyl aniline | | | Benzenamine | 18. | Amine | Common Name | IUPAC Name | | ------------------------ | ------------------- | ------------------- | | CH3CH2CH2NH2 | | propan -1 -amine | | | Isopropylamine | | | | | N, N-diethyl-butan-1-amine | | NH2-CH2-CH=CH2 | | | ## Topic 4: Preparation of Amines 21. **alkyl** and **nucleophilic** 22. ammonolysis 23. **True** 24. | | A | B | C | D | | ------------------------ | ------------------- | ------------------- | ------------------- | ------------------- | | | C6H5NO2 | C6H5NH2 | C6H5N2Cl | C6H5F | 25. | | (i) | (ii) | | ------------------------ | ------------------- | ------------------- | | | RNH2 | R2N | ## Topic 5: Physical Properties 42. **Fishy** 43. Higher amines - Gas 44. **True** 45. **sparingly soluble** in water 46. C6H5NH2, C2H5NH2 , (C2H5)2NH  47. Solubility ≤ 1/molar mass of amines 48. **insoluble** 49. **Only II** * Alcohols are less polar than amines. * Amines form weaker intermolecular hydrogen bonds than alcohols. 50. **Secondary amines** 51. **no** 52. Tertiary amines, Primary amines, Secondary amines  53. n-C₄H₉NH2  ## Topic 6: Chemical Reactions 54. * The presence of a lone pair of electrons on nitrogen * The presence of carbon-nitrogen bond 55. **True** 56. nucleophile 57. **basic** 58. R- NH2 + HCl → [R - NH3]+ Cl- 59. A: R, B: H+, C: X- 60. **Water** 61. Lewis bases 62. **higher** 63. +I-effect 64. **Aromatic amines** 65. Electron donating nature 66. Both I and II 67. A: Electron releasing, B: Electron withdrawing 68. **stronger** 69. NH3, Primary amines, Secondary amines, Tertiary amines  70. **R-N-H---OH2** * **H---OH2** 71. **True** 72. * Steric hindrance * The +I effect of the alkyl group  * Solvation effects 73. NH3, C2H5NH2, (C2H5)2NH, (C2H5) 3N  ## Topic 7: Methods of Preparation, Physical and Chemical Properties of Diazonium Salts 106. R-N2-X+  107. | | (i) | (ii) | | ------------------------ | ------------------- | ------------------- | | | Benzenediazonium Chloride | benzenediazonium hydrogen sulfate | 108. **True** 110. ArNH2 + NaNO2/HCl, 0-5°C → ArN2Cl + 2H2O 111. **4** 112. Colourless, Crystalline solids, Soluble in water 113. **Br** 114. Both I and II 115. N2 + HCl + CuCl ## Topic 8: Importance of Diazonium Salts in Synthesis of Aromatic Compounds 120. | Column I (Reactions) | Column II (Reagents) | | ------------------------ | ------------------- | | | H₂O/H3PO2 | | | NaNO2/HCI | | | KMnO4/OH | 121. | | | | | ------------------------ | ------------------- | ------------------- | | | NaNO2/HCl | Sn/HCl | 122. A: * -N2(+)Cl(-) * CH3 * Br B: * -NH2 * CH3  * Br 123. * Br * NO2 * NH2 * H * H * H * H * H * H * H * H 124. **orange** 125. Diazonium chloride salt ## Assertion-Reason Questions 1. **Both A and R are true but R is not the correct explanation of A.** 2. **Both A and R are true and R is the correct explanation of A.** 3. **Both A and R are true and R is the correct explanation of A.** 4. **A is false but R is true.** 5. **Both A and R are true and R is the correct explanation of A.** 6. **A is false but R is true.** 7. **Both A and R are true but R is not the correct explanation of A.** 8. **Both A and R are true and R is the correct explanation of A.**  9. **Both A and R are true and R is the correct explanation of A.** 10. **A is true but R is false.**