CPJE Top 400 Drugs Training Wheel Flashcards PDF

CG CPJE Top 400 Drugs training wheel 11 studiers today Leave the first rating Others also viewed these textbooks Clinical Reasoning Cases in Nursing Pharmacology and 7th Edition • ISBN: 9780323527361 7th Edition • ISBN: 97803 Julie S Snyder, Mariann M Harding Julie S Snyder, Linda Lille 2,56...

CG CPJE Top 400 Drugs training wheel 11 studiers today Leave the first rating Others also viewed these textbooks Clinical Reasoning Cases in Nursing Pharmacology and 7th Edition • ISBN: 9780323527361 7th Edition • ISBN: 97803 Julie S Snyder, Mariann M Harding Julie S Snyder, Linda Lille 2,565 solutions 397 solutions Search for a textbook or question Students also viewed htn combo drugs 25 terms Preview sandy_li2 Terms in this set (416) Azithromycin CI: hepatic dysfxn w/ prior use Warnings: Zithromax, Z-Pak (D,food,SE) -QT prolongation -Hepatotoxicity 500mg on Day 1, then 250mg Days 2-5 *No renal dose adjustment Clarithromycin CI: hepatic dysfxn w/ prior use; current lovastatin or simvastatin use; colchicine in RI/HI; h/o QT prolongation or ventricular arrhythmias Warnings: -QT prolongation Biaxin (D,SE) -Hepatotoxicity -Major CYP3A4 inhibitor -Caution in pts with CAD PO: 250-500mg Q12H or 1g XL daily *Dose adjust for CrCl <30 *Do not refrigerate reconstituted oral suspension https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 1 of 54 Erythromycin CI: hepatic dysfxn w/ prior use; current lovastatin or simvastatin use Warnings: -QT prolongation E.E.S, Ery-Tab, Erythrocin (D,SE) -Hepatotoxicity -Major CYP3A4 inhibitor 400mg PO QID *No renal dose adjustment *Refrigerate oral suspension Trimethoprim/sulfamethoxazole -SS: 400mg SMX/80mg TMP -DS: 800mg SMX/160 mg TMP Bactrim, Septra (D,CI,food,SE) CI: sulfa allergy, pregnancy/bf, folate deficiency anemia, severe RI/HI, <2months old Warnings: G6PD def; Blood dyscrasias; SJS/TEN, TTP; Teratogenic *Mod-strong CYP2C8 and 2C9 inhibitor SE: -crystalluria, photosensitivity hemolytic anemia, hyperkalemia Daptomycin, IV only Warnings: -Eosinophilic pneumonia (Not used for pneumonia!) -Myopathy/rhabdo -False ↑PT/INR (but not bleed risk) Cubicin (Warnings, monitoring, use) -Peripheral neuropathy Monitor CPK weekly (dc if >10,000 units/L or >1,000 + muscle pain) neuropathy, dyspnea Approved for complicated SSTI, MRSA; active against both sp. of VRE, E. faecium & E. faecalis Linezolid CI: MAOI within 14 days Warnings: -Myelosuppression -Peripheral/optic neuropathy -Serotonin syndrome Zyvox (CI, Warnings, Monitoring, use, D) -Hypoglycemia Monitor CBC weekly MRSA, VRE (E. faecium & E. faecalis) PO/IV: 600mg Q12H *No renal dose adjustment Minocycline Warnings: ≤8yo, pregnant/bf Minocin, Solodyn, Dynacin (Warnings, D) -photosensitivity -drug-induced lupus PO/IV: 200mg x1 f/b 50-100mg Q12H https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 2 of 54 Doxycycline Warnings: ≤8yo, pregnant/bf Vibramycin (D, Warnings) photosensitivity PO/IV: 100mg bid WF (for GI upset) +8oz H₂0; sit upright 30min to avoid esophageal irritation *No renal dose adjustment Tigecycline BBW: ↑risk of death, use only when alternative treatments are not suitable Warnings: Hepatotoxicity, pancreatitis, photosensitivity, avoid in <8yo, ↓cure rates in VAP -Do not use for bloodstream infxns (lipophilic) Tygacil (BBW, warnings, D, coverage) IV: 100mg x 1, then 50mg bid *Reconstituted soln is yellow/orange *No renal dose adjustment Covers: MRSA, VRE, GN, anaerobes, and atypicals but LACKS activity against the "3 Ps" -Pseudomonas, Proteus, Providencia Liposomal Amphotericin B Used as initial tx for many invasive infxns including Cryptococcal meningitis, histoplasmosis, mucormycosis BBW: Death d/t errors confusing lipid based (AmBisome, Abelcet) & conventional deoxycholate→ AmBisome (Use, BBW, SE) max 1.5mg/kg/day, requires pre-med *verify product name/dose if >1.5mg/kg/day *OD can cause cardiopulmonary arrest SE: infusion-rxns; thrombophlebitis, ↓K, MG, nephrotoxicity Injection: 3-6mg/kg/day Fluconazole Fungal meningitis (Penetrates CNS) *Reliable activity against C. albicans & C. tropicalis Warnings: hepatotoxicity, SJS, avoid in pregnancy; Diflucan (D,SE) *strong inhibitor of 3A4, 2C9, 2C19 SE: ↑ LFTs, QT prolongation PO/IV ratio is 1:1; 500-800mg daily Vaginal candidiasis: 150mg po x1 * ↓dose 50% for CrCl <50 Flucytosine (5-FC) Used with amphoB for invasive Cryptococcal meningitis or Candida infxns Ancobon (use, BBW, SE) BBW: Extreme caution in pts with RI, monitor hematologic, renal & hepatic status closely SE: myelosuppresion (dose related), ↑Sc, BUN, hepatitis, ↑bilirubin, many CNS effects, hypoglycemia, ↓K Terbinafine (Rx = po) I: onychomycosis Lamisil (I,W,D) W: hepatotoxic 250mg po daily (6 wks for fingernail, 12 wks toenail) Nystatin Mycostatin, Bio-Statin (I,D) Thrush: Swish and swallow 4-5 times daily -Vaginal insert: 100,000 unit x 2 weeks https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 3 of 54 Voriconazole *DOC for Aspergillus CI: use of 3A4 inducers: PPE PCORNSS, ergot alkaloids pimozide, quinidine, ritonavir, sirolimus, terfenadine, astemizole, barbiturates Warnings: Hepatotoxicity, optic neuritis, phototoxicity, avoid in pregnancy, QT prolongation, infusion rxns, SJS; strong 3A4 inhibitor & substrate Vfend, Vfend IV (I, CI, warnings, SE D) SE: visual changes (20%), ↑LFTs, Scr, CNS toxicities, ↓K, BG LD: 5mg/kg IV Q12H x2 MD: 4mg/kg IV Q12H or 200mg po Q12H Target trough: 1-5mcg/mL *CrCl <50: oral vori preferred (SBECD IV vehicle accumulates) *take on empty stomach Posaconazole CI: use of sirolimus, atorvastatin, lovastatin, simvastatin, quinidine Warnings: QT prolongation, med errors (tablet & suspension are not interchangeable), neurotoxicity Noxafil (CI, warnings, admin) with vincristine Oral treatment preferred if eGFR <50 *Take with a full meal Caspofungin (IV) Cancidas Candidemia Given once daily; no renal dose adjustment Warnings: histamine mediated rxns, ↑ LFTs, SJS Micafungin Mycamine Candidemia/esophageal candidiasis Given once daily; no renal dose adjustment Warnings: histamine mediated rxns, ↑ LFTs, SJS Iron Sucrose (IV) Venofer Total dose needed to replenish iron stores: 1,000mg; can be given in a single infusion *Give by slow IV infusion to ↓risk of hypotension SE: All parenteral iron products carry a risk for hypersensitivity rxns (including anaphylaxis) Ferumoxytol (IV iron) BBW: serious/fatal anaphylactic rxns Feraheme *Slow IV infusion to ↓risk of hypotension Total dose needed to replenish iron stores: 1,000mg; can be given in a single infusion Injection (IM/deep SC) Lozenges, tablets, SL liquid Nasal solution (Nascobal): one nostril once weekly Cyanocobalamin (B12) -Formulations,CI,Warnings CI: Cobalt or vitamin B12 allergy (intradermal test dose recommended if suspected sensitivity prior to intranasal or injectable use) Warnings: parenteral products may contain aluminum (accumulation can cause CNS & bone toxicity in RI) or benzyl alcohol (can cause fatal toxicity & "gasping syndrome" in neonates) https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 4 of 54 Filgrastim (Neupogen) Pegfilgrastim (Neulasta) Colony Stimulating Factors: stimulate WBC production, ↓ time pt is at risk for infxn d/t neutropenia & Neupogen & Neulasta ↓ mortality from infxn when given as ppx -IV/SC, started 24-72H AFTER chemo Indication: all patients with >20% chance of chemo-induced febrile neutropenia SE: bone pain, arthralgias, myalgias, fever, rash; pts should report any signs of enlarged spleen (upper L abdominal pain or respiratory distress syndrome) Neulasta: do not give within 14 days prior to next chemo cycle Meperidine (opioid, CII) 50-150mg IM/PO q3-4h prn *short DOA (3hrs) Demerol (D,DOA,Uses,SE,) *No longer recommended as an analgesic *Used off-label for post-op rigors (shivering) SE: serotonergic; CNS toxicity including seizures (esp. in renal impairment) Morphine ER (po) MS Contin, Kadian, Roxanol, Oramorph, Avinza (D) -15-200mg po Q8-12H prn Kadian: capsule contents can be sprinkled on food Infumorph, Duramorph (D) Morphine IR for IV injection 2.5-5 mg Q3-4H prn (opioid-naive) Hydrocodone/acetaminophen Norco, Lortab, Lorcet, Vicoden (D) 2.5-10/325mg po q4-6h prn BBW: Starting 3A4 inhibitors (or stopping inducers) can cause fatal OD Hydrocodone/ibuprofen Vicoprofen, Ibudone (D) 5-7.5/200mg po q4-6h prn BBW: Starting 3A4 inhibitors (or stopping inducers) can cause fatal OD Oxycodone IR 5-20mg po q4-6hr Roxicodone (D, BBW) *Lower dose/avoid in renal impairment BBW: Starting 3A4 inhibitors (or stopping inducers) can cause fatal OD Oxycodone CR BBW: Starting 3A4 inhibitors (or stopping inducers) can cause fatal OD OxyContin (D, BBW) 10-80mg po bid *Lower dose/avoid in renal impairment Oxycodone/acetaminophen (IR) BBW: Starting 3A4 inhibitors (or stopping inducers) can cause fatal OD Percocet, Endocet (D, BBW) 2.5-10/325mg po q4-6hr *Lower dose/avoid in renal impairment Percodan (D) https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY Oxycodone/aspirin (IR) 4.83/325mg po q6h prn (max 12 tabs/hr) 1/7/24, 6:06 PM Page 5 of 54 Methadone BBW: QT prolongation; Major 3A4 substrate: starting inhibitors or stopping inducers can cause fatal Dolophine (D,I,BBW) OD *Opioid addiction, chronic pain 2.5-10mg q8-12hr Hydromorphone BBW: Risk of med errors with high potency (HP) injection (use in opioid-tolerant pts only) Dilaudid (D -PO/IV, BBW) Dilaudid HP (10mg/mL) vs Dilaudid (1mg/mL) 1.5mg IV/IM = 7.5mg PO = 10mg morphine IV/IM = 30mg morphine PO Fentanyl injection Sublimaze (D IM/IV, BBW) BBW: mod-strong 3A4 inhibitors ↑ effects; potential med errors when converting between dosage forms Fentanyl patch Med Guide 1 patch q72 Duragesic (D, BBW) *Apply on upper arm, chest or back BBW: mod-strong 3A4 inhibitors ↑ effects; potential med errors when converting between dosage forms; avoid exposing patch to external heat Fentanyl IR transmucosal lozenge Med Guide Only indicated for cancer BTP Actiq (D, I) 200mcg x up to 4 BTP episodes/day. REMS: requires documentation of pt's opioid tolerance with each Rx BBW: mod-strong 3A4 inhibitors ↑ effects; potential med errors when converting between dosage forms I: pain, cough *Converted to morphine by 2D6: avoid 2D6 inhibitors; risk of respiratory depression in ultra-rapid metabolizers BBW: resp. depression / death (including children who received codeine after tonsillectomy or Codeine (CV) adenoidectomy & nursing infants of mothers who were ultra-rapid metabolizers) CI: <12 yo; <18 yo following tonsillectomy/adenoidectomy Nalbuphine Mixed opioid agonist/antagonist (not a C.S.) Nubain, Nalpain (I,Max) I: pain in labor/anesthesia max 160mg/day Tramadol, CIV Med Guide IR: 50-100mg po q4-6h prn (Max 400 mg/day) Ultram (D, CI, SE, sched) *Requires conversion to active metabolite by 2D6: avoid 2D6 inhibitors CI: <12 yo; <18 yo following tonsillectomy/adenoidectomy SE: Seizure, serotonin syndrome risks https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 6 of 54 Tapentadol, CII (opioid & NE reuptake inhibitor) Med Guide Nucynta (D,SE, sched) 50-100mg q4-6 hr prn SE: Seizure, serotonin syndrome risk *less GI effects than other opioids Narcan (D) Naloxone nasal spray 4 mg in one nostril; may need to repeat dose(s) in alternating nostrils Nalmefene Revex (I) Opioid antagonist *for opioid OD Naltrexone Med Guide ReVia, Vivitrol Opioid antagonist for alcohol and opioid dependence ReVia = daily po tablet Vivitrol = monthly IM injection -25mg po x 1, then 50mg po qd on Day 2 Isoniazid I: TB (included in latent and active TB regimens) BBW: severe/fatal hepatitis INH (D,BBW,I,SE) CI: active liver dz, previous severe adverse rxn to INH Warnings: peripheral neuropathy (supplement pyridoxine/B6 25mg/d); drug-induced lupus; hemolytic anemia; agranulocytosis, optic neuritis D: 300mg po daily on an empty stomach Rifampin CI: use with protease inhibitors SE: ↑LFTs, orange body fluids, (+) Coombs test, flu-like syndrome Max dose: 600mg po daily, take on empty stomach Rifadin (CI, SE, D, DDIs) Potent inducer of 1A2, 2C8, 2C9, 2C19, 3A4 and P-gp Warfarin: very large ↓ in INR is common Oral contraceptives: ↓ efficacy DOACs: should be avoided Peginterferon alfa 2a & 2b Pegasys & PegIntron (D, BBW) -2a: Pegasys 180 mcg SC qw -2b: PegIntron 1.5mcg/kg SC qw *BBW: worsening autoimmune system, infection, psych problems, ischemic problems, blood problems Ribavirin (po for HCV) Med Guide I: HCV in combination with DAAs and/or IFNɑ BBW: teratogenic; not effective for monotherapy of HCV; hemolytic anemia CI: Pregnancy, women of childbearing potential, male partners of pregnant women, Ribasphere, Rebetol, Copegus (BBW,CI,SE) hemoglobinopathies, CrCl <50, autoimmune hepatitis, use of didanosine SE: insomnia, anorexia, myalgias, hypothyroidism Monitoring: CBC + diff, PLTs, e-lytes, LFTs/bili, HCV-RNA, TSH, monthly pregnancy tests Note: avoid pregnancy during & for 6 months after completion. 2 forms of BC req'd during & for 6 months post-tx (also applies to female partners of males who are being treated) *Combo SEs: anemia, birth defects, eye problems https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 7 of 54 Simeprevir I: Hep C genotype 1 & 4 Olysio (I,D,food,SE) D: 150mg po qd x 12 weeks + PEG-IFN/RBV or sofosbuvir *Take w/ food *SEs: anemia, requiring ESA, photosensitivity Acyclovir I: HSV-1 & HSV-2, invasive HSV including HSV encephalitis (IV); shingles Warnings: TTP/HUS in immunocompromised; maintain hydration, infuse slowly over 1H to prevent renal Zovirax (I,D,food) damage; ↑LFTs, neutropenia, seizures *Dose based on IBW, even in obese pts PO: 200-800mg 5x daily Topical cream: Apply 5x daily for 4 days (can be used on oral or genital sores) Valacyclovir Valtrex (I,D) I: HSV, shingles Shingles: 1g po TID x7 days *Prodrug of acyclovir Famciclovir Famvir (I,D) I: HSV, shingles -Shingles: 500mg po tid x 7 days w/in 72 hrs onset Ganciclovir I: DOC for CMV disease BBW: myelosuppression; carcinogenic, teratogenic Cytovene (I, BBW, SE, W) SE: thrombocytopenia, neutropenia, leukopenia; ↑ Scr Hazardous Drug: special handling req'd Reproductive potential: females should use contraception during tx + 30 days after, males for 90 days ValGANciclovir *Prodrug of ganciclovir I: DOC for CMV disease Valcyte (I, BBW, SE, W) BBW: myelosuppression; carcinogenic, teratogenic SE: thrombocytopenia, neutropenia, leukopenia; ↑ Scr; retinal detachment (monitor) Hazardous Drug: special handling req'd Reproductive potential: females should use contraception during tx + 30 days after, males for 90 days Amantadine I: Parkinson's: for initial tremor Symmetrel (I,D) D: 100mg po bid or tid W: Psychosis, livedo reticularis (mottled purplish discoloration of the lower extremities) - d/c SE: Dizziness (light-headedness), orthostasis Oseltamivir I: flu tx and ppx; preferred in pregnancy Warnings: neuropsychiatric events, SJS Tamiflu (I,D,SE,age,time to start) Tx: 75mg po BID x 5 d Ppx: 75mg po QD x 10 d *Dose adjust for CrCl <60 https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 8 of 54 Zanamivir I: flu tx and ppx Relenza (I,D,ROA,age) Tx: 10mg po BID x 5 d Ppx: 10mg po QD x 10 d *oral inhalation *for >/= 7 yoa Foscarnet Foscavir (BBW) BBW: only for CMV retinitis in immunocompromised pts and acyclovir-resistant HSV; renal impairment, seizures Dornase alfa Pulmozyme (I,D) I: cystic fibrosis D: 2.5mg nebulizer qd or bid if needed Atenolol Max dose: 100mg qd *Cardioselective Tenormin (max,BBW,COi,SE) BBW: Do not stop abruptly to avoid acute tachycardia, HTN and/or ischemia *CI: diabetes, asthma/COPD, bradycardia, heart block *SE: dyslipidemia, weight gain, fluid retention, fatigue, dizziness Metoprolol tartrate *IR *Cardioselective Lopressor (Max,BBW,CI,SE) *Max: 450mg/d (doses are bid) *BBW: Do not stop abruptly to avoid acute tachycardia, HTN and/or ischemia *CI: diabetes, asthma/COPD, bradycardia, heart block *SE: dyslipidemia, weight gain, fluid retention, fatigue, dizziness Metoprolol succinate β1 selective -HTN: Max 400mg/day Toprol XL (I,max,BBW,CI,SE) -HF Target dose: 200mg/d BBW: Do not stop abruptly CI: diabetes, asthma/COPD, bradycardia, heart block SE: dyslipidemia, weight gain, fluid retention, fatigue, dizziness Esmolol *IV only for HTN emergency Brevibloc (I,BBW,CI,SE) β1 selective BBW: Do not stop abruptly CI: diabetes, asthma/COPD, bradycardia, heart block SE: dyslipidemia, weight gain, fluid retention, fatigue, dizziness Ranolazine I: stable ischemic heart dz (inhibits late Na current & ↓ intracellular Ca) *Little to no effect on HR or BP CI: Cirrhosis, strong 3A4 inhibitors & inducers Ranexa (CI, W, M) W: QT prolongation M: ECG, K, renal function Dosed BID *500mg BID when used with mod3A4 inhibitors (diltiazem, verapamil) *Max 20mg simvastatin if used together https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 9 of 54 Propranolol (Nonselective) IR: 80mg BID, ER: 80mg QD (Max for both: 640mg/d) Inderal (D,food,BBW,CI,SE) *Take with food BBW: Do not stop abruptly CI: diabetes, asthma/COPD, bradycardia, heart block SE: dyslipidemia, weight gain, fluid retention, fatigue, dizziness Timolol (Nonselective) 40mg po BID Blocadren (D,BBW,CI,SE) BBW: Do not stop abruptly CI: diabetes, asthma/COPD, bradycardia, heart block SE: dyslipidemia, weight gain, fluid retention, fatigue, dizziness Timolol eye drops I: Glaucoma CI: asthma/COPD, bradycardia, CHF Timoptic, Betimol (I,CI,SE) Caution: arrhythmias, diabetes, depression, thyroid dz SE: bronchospasm, ↓ HR/BP, ↓ libido, depression Dosed BID Bepreve Ciprodex Bepotastine eye drops 2nd gen antihistamine Ciprofloxacin/dexamethasone ear drops Timolol/dorzolamide Cosopt (I,CI,SE) I: Glaucoma CI: sulfa allergy, kidney disease SE: metallic taste, HA, hypokalemia Labetalol (Nonselective; also blocks α1) 800mg po BID (Max: 2400mg/d) Normodyne, Trandate (I,food,BBW,CI,SE) *Take with food BBW: Do not stop abruptly CI: diabetes, asthma/COPD, bradycardia, heart block SE: dyslipidemia, weight gain, fluid retention, fatigue, dizziness Carvedilol, nonselective BB, also blocks α1 BBW: Do not stop abruptly to avoid acute tachycardia, HTN and/or ischemia CI: diabetes, asthma/COPD, bradycardia, heart block SE: dyslipidemia, wt gain, fluid retention, fatigue, dizziness Coreg (BBW,CI,SE,D) 3.125-25 mg po BID with food HF target dose: 25mg po BID 6.25mg IR = 20 mg CR Carteolol Ocupress (I,CI,SE) I: glaucoma *CI: asthma/COPD, bradycardia, CHF, depression or MG *SE: bronchospasm, bradycardia, low BP and libido, CNS depression Betaxolol Betoptic (I,CI,SE) I: glaucoma *CI: asthma/COPD, bradycardia, CHF, depression or MG *SE: bronchospasm, bradycardia, low BP and libido, CNS depression https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 10 of 54 Diltiazem Cardizem (I,max,SE) I: HTN, angina Max dose: 120mg/day qd, bid or tid SE: bradycardia, gingival hyperplasia, constipation Verapamil I: HTN, angina Max dose: 120mg/day qd, bid or tid Calan, Isoptin, Verelan, Covera (I,max,SE) *non-DHP (more cardioselective) *Preferred if CKD and nephropathy *SE: bradycardia, gingival hyperplasia, constipation *Ok to give in HF if EF is normal Amlodipine I: HTN, angina Max dose: 10mg/d Norvasc (I,max,CI,SE) CI: CHF, do not give w/ BB if acute MI SE: reflex tachycardia, HA, flushing, edema, gingival hyperplasia Major 3A4 substrate: Max 20mg simvastatin Felodipine ER I: HTN, angina Plendil (I,max,CI,SE) Max dose: 10mg/d CI: CHF, do not give w/ BB if acute MI SE: reflex tachycardia, HA, flushing, edema Isradipine CR I: HTN, angina DynaCirc (I,CI,SE) Max dose: 10mg/d CI: CHF, do not give w/ BB if acute MI SE: reflex tachycardia, HA, flushing, edema Nicardipine I: HTN, angina Cardene (I,D,CI,SE) 60mg BID or TID CI: CHF, do not give w/ BB if acute MI SE: reflex tachycardia, HA, flushing, edema Nifedipine ER I: HTN, angina Adalat CC, Procardia XL (I,max,CI,SE) Max dose: 90mg/d CI: CHF, do not give w/ BB if acute MI SE: reflex tachycardia, HA, flushing, edema Doxazosin alpha blocker (nonselective) I: BPH, HTN (2ⁿᵈ or 3ʳᵈ line) Cardura (I,D,SE) IR: start 1mg QHS, titrate slowly (orthostasis/syncope esp. w/ 1st dose) Cardura XL: take 4mg w/ BF; can leave a ghost tablet in stool *must taper off Prazosin I: HTN (2ⁿᵈ or 3ʳᵈ line), BPH Minipress (I,D,SE) D: 5mg po bid or tid (for both indications) *Caution: syncope, dizziness, fatigue --> Titrate *must taper off https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 11 of 54 Terazosin (Non-selective α blocker) I: BPH, HTN (2ⁿᵈ or 3ʳᵈ line), BPH Hytrin (I,D,SE) BPH: start 1mg po QHS, titrate slowly (1st dose syncope) *Normal dose: 10mg QHS (max 20mg) *must taper off Clonidine ER I: ADHD Kapvay 0.1mg QHS (max 0.4mg/day) *must be tapered off to ↓ risk of rebound hypertension, nervousness & anxiety Guanfacine ER I: ADHD 1mg daily (max 4mg/day with stimulants, or 7mg/day when used alone) Intuniv *Do not take with high-fat meal (↑ absorption) W/ strong 3A4 inducers double dose W/ strong 3A4 inhibitors: ↓ dose 50% Must be tapered off to ↓ risk of rebound HTN, nervousness, anxiety Clonidine I: resistant HTN or pts who can't swallow, ADHD *off-label: opioid withdrawal, anxiety and sleep Catapres, Catapress TTS-1,2,3 (I,D,apply,SE) D: -0.1-0.3 mg po BID -0.1, 0.2, 0.3 mg/24 hr/wk *Apply to upper outer arm or chest and rotate site weekly *Caution: bradycardia, dry mouth, fatigue, depression, psych rxns, impotence, rebound HTN *must taper off Methyldopa D: 500mg BID (max 3000mg/d) Aldomet (D,SE) *SE: lupus sx, hepatitis, myocarditis, hemolytic anemia *Caution: bradycardia, dry mouth, fatigue, depression, psych rxns, impotence, rebound HTN *preferred in pregnancy *must taper off Reserpine Serpasil (I,D,SE) I: HTN (old drug) Caution: bradycardia, depression *must taper Hydralazine I: HTN Apresoline (I,D,SE) D: 75mg po qid *SE: lupus *Caution: reflex tachycardia Minoxidil I: HTN Loniten (I,D,SE) D: 40mg po qd *SE: hair growth *Caution: reflex tachycardia https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 12 of 54 Chlorothiazide (IV/PO) [Thiazide] I: HTN, edema D: 500-2000 mg qd in 1-2 divided doses Diuril CI: Sulfa allergy SE: metabolic alkalosis, ↓K, Na, Mg, and ↑BG, TG, Chol, UA, Ca Not effective if CrCl < 30 *Can ↓Lithium renal CL and lead to toxicities HCTZ/triamterene I: HTN, edema Dyazide, Maxzide D: 1-2 tabs po qd *CI: Sulfa allergy *SE: metabolic alkalosis, decreases K+, Na+ and Mg2+, increases BG, TG, Chol, uric acid and Ca2+ *Diuretic of choice if no renal impairment Hydrochlorothiazide [Thiazide] I: HTN, edema D: 12.5-50mg PO QD *CI: Sulfa allergy Microzide *SE: metabolic alkalosis, ↓ K+, Na+, Mg2+, and ↑ BG, TG, Chol, uric acid and Ca2+ *Diuretic of choice if no renal impairment Not effective if CrCl < 30 *Can ↓Lithium renal CL and lead to toxicities Chlorthalidone I: HTN D: 12.5 - 25mg QD CI: Sulfa allergy Thalidone (I,D,CI,SE) SE: metabolic alkalosis, ↓K, Na, Mg, ↑BG, TG, Chol, UA, Ca *Better at ↓ BP than loop diuretics, 1st line agent Not effective if CrCl < 30 *Can ↓Lithium renal CL and lead to toxicities Metolazone [thiazide] I: HTN, edema Zaroxolyn (I,D,CI,SE) D: target dose 20mg/d *CI: Sulfa allergy *SE: metabolic alkalosis, decreases K+, Na+ and Mg2+, increases BG, TG, Chol, uric acid and Ca2+ *Ok if there's renal dysfunction Indapamide [thiazide] I: HTN, edema Lozol (I,D,CI,SE) D: Target dose 2.5mg/d CI: Sulfa allergy SE: metabolic alkalosis, ↓K, Na, Mg, ↑BG, TG, Chol, UA, Ca Furosemide I: HTN, HF, edema D: Target dose 40mg po BID (max: 600mg/d) Lasix (I,D,CI,SE,loop equal) CI: sulfa allergy SE: metabolic alkalosis, Decreases K+, Na+, Mg2+, Ca2+ and bone density, increases BG, TG, Chol, and uric acid *IV: Ototoxicity and avoid use w/ aminoglycosides *Equivalency: BTFE = 1:20:40:50 https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 13 of 54 Torsemide I: HTN, HF, edema D: Target dose 10mg qd *CI: sulfa allergy Demadex (I,D,CI,SE) *SE: metabolic alkalosis, Decreases K+, Na+, Mg2+, Ca2+ and bone density, increases BG, TG, Chol, and uric acid *Requires K+ supp *Diuretic of choice for renal disease *IV: Ototoxicity and avoid use w/ aminoglycosides *Equivalency: BTFE = 1:20:40:50 Bumetanide I: HTN, HF, edema D: Target dose: 1mg po bid *CI: sulfa allergy Bumex (I,D,CI,SE) *SE: metabolic alkalosis, Decreases K+, Na+, Mg2+, Ca2+ and bone density, increases BG, TG, Chol, and uric acid *Requires K+ supp *Diuretic of choice for renal disease *IV: Ototoxicity and avoid use w/ aminoglycosides *Equivalency: BTFE = 1:20:40:50 Ethacrynic acid I: HTN, HF, edema SE: metabolic alkalosis, ↑BG, TG, Chol, uric acid ↓K+, Na+, Mg²⁺, Ca²⁺, BMD Edecrin (I,D,SE) *IV: Ototoxicity; avoid use w/ aminoglycosides *Diuretic of choice for renal disease *only loop that is ok in sulfa allergy 25-50mg po daily *Equivalence: BTFE = 1:20:40:50 Triamterene [K+ Sparing Diuretics] I: HTN, glaucoma, edema Dyrenium D: 300mg po qd *SE: metabolic acidosis, Increase K+, decrease Ca2+, gout *CI if CrCl <30 Amiloride I: HTN, glaucoma, edema Midamor (I,D,SE,CI) D: 20mg po qd *K+-sparing diuretic *SE: metabolic acidosis, Increase K+, decrease Ca2+, gout *CI if CrCl <30 Spironolactone I: HF (decreases morbidity), HTN Aldactone (I,D,SE,CI) D: 25-50mg po qd *K+-sparing diuretic *SE: gynecomastia, metabolic acidosis, Increase K+, decrease Ca2+, gout *CI: pregnancy, CrCl <30 Eplerenone (aldosterone antagonist) I: HF (EF <35% or post-MI for EF <40%), HTN CI: pregnancy, Scr >2, CrCl <30, K>5 Inspra (I,D,SE,CI) SE: ↑K+ D: 25-50mg po qd HF target dose: 50 mg daily https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 14 of 54 Benazepril I: HTN BBW: pregnancy, bilateral renal artery stenosis Lotensin (I,D,BBW,SE) SE: metabolic acidosis, ↑K+, dry cough, angioedema *Avoid w/ NSAIDs bc of renal damage 10-40mg po daily or in 2 divided doses Captopril I: HTN, HF Capoten (i,D,BBW,SE) Target dose: 50mg po tid BBW: pregnancy, bilateral renal artery stenosis SE: metabolic acidosis, ↑K+, angioedema, dry cough *Avoid NSAIDs - renal damage Enalapril I: HTN, HF Vasotec (i,D,BBW,SE) Target dose: 20mg po qd BBW: pregnancy, bilateral renal artery stenosis SE: metabolic acidosis, ↑K+, angioedema, dry cough *Avoid NSAIDs - renal damage Fosinopril I: HTN, HF Monopril (I,D,BBW,SE) Target dose: 40mg po qd BBW: pregnancy, bilateral renal artery stenosis SE: metabolic acidosis, ↑K+, angioedema, dry cough *Avoid NSAIDs - renal damage Lisinopril I: HTN, HF Zestril, Prinivil (I,D,BBW,SE) Target dose: 20mg po qd BBW: pregnancy, bilateral renal artery stenosis SE: metabolic acidosis, ↑K+, angioedema, dry cough *Avoid NSAIDs - renal damage Moexipril I: HTN, HF Univasc (i,D,BBW,SE) Target dose: 15mg po qd BBW: pregnancy, bilateral renal artery stenosis SE: metabolic acidosis, ↑K+, angioedema *Avoid NSAIDs - renal damage Quinapril I: HTN, HF Accupril (I,D,BBW,SE) Target dose: 40mg po qd BBW: pregnancy, bilateral renal artery stenosis SE: metabolic acidosis, ↑K+, angioedema *Avoid NSAIDs - renal damage Ramipril I: HTN, HF Altace (I,D,BBW,SE) Target dose: 10mg po qd BBW: pregnancy, bilateral renal artery stenosis SE: metabolic acidosis, ↑K+, angioedema *Avoid NSAIDs - renal damage https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 15 of 54 Candesartan I: HTN, HF Atacand (I,D,BBW,SE) Target dose: 32mg po qd BBW: pregnancy, bilateral renal artery stenosis SE: metabolic acidosis, ↑K+, angioedema *Avoid NSAIDs - renal damage Irbesartan I: HTN, HF Avapro (I,D,BBW,SE) Target dose: 300mg po qd BBW: pregnancy, bilateral renal artery stenosis SE: metabolic acidosis, ↑K+, angioedema *Avoid NSAIDs - renal damage Losartan I: HTN, HF Cozaar (I,D,BBW,SE) Target dose: 50-100mg po qd BBW: pregnancy, bilateral renal artery stenosis SE: metabolic acidosis, ↑K+, angioedema *Avoid NSAIDs - renal damage Valsartan I: HTN, HF Diovan (I,D,BBW,SE) Target dose: 320mg po qd BBW: pregnancy, bilateral renal artery stenosis SE: metabolic acidosis, ↑K+, angioedema *Avoid NSAIDs - renal damage Olmesartan I: HTN, HF Benicar, (I,D,BBW,SE) Target dose: 40mg po qd BBW: pregnancy, bilateral renal artery stenosis SE: sprue-like enteropathy; metabolic acidosis, ↑K+, angioedema *Avoid NSAIDs - renal damage Telmisartan I: HTN, HF Micardis (I,D,BBW,SE) Target dose: 80mg po qd BBW: pregnancy, bilateral renal artery stenosis SE: metabolic acidosis, ↑K+, angioedema *Avoid NSAIDs - renal damage Aliskiren I: HTN Target dose: 300mg po qd Tekturna (I,D,BBW,SE, food) *BBW: pregnancy, bilateral renal artery stenosis *SE: metabolic acidosis, increase K+, dry cough, angioedema *Avoid w/ NSAIDs bc of renal damage *High fat meals decreases absorption Lovastatin IR I: high cholesterol Mevacor (I,D,CI,SE,food) D: 20 po qd or bid with food (Max: 80mg/d) CI: Pregnancy *Caution: rhabdomyolysis, myopathy https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 16 of 54 Atorvastatin I: high cholesterol Lipitor (I,D,CI,SE) D: 10-80mg po qd *CI: Pregnancy *Caution: rhabdomyolysis, myopathy *medium-high intensity Fluvastatin IR I: high cholesterol D: 20-80mg po qd Lescol (I,D,CI,SE,time) *CI: Pregnancy *Caution: rhabdomyolysis, myopathy *low-medium intensity *Take at bedtime Rosuvastatin I: high cholesterol Crestor (I,D,CI,SE) D: 5-20mg po qd *CI: Pregnancy *Caution: rhabdomyolysis, myopathy *medium-high intensity Pravastatin I: high cholesterol Pravachol (I,D,CI,SE) D: 10-80mg po qd *CI: Pregnancy *Caution: rhabdomyolysis, myopathy *low-medium intensity Simvastatin I: high cholesterol D: 10-40mg po qd Zocor (I,D,CI,SE,time) *CI: Pregnancy *Caution: rhabdomyolysis, myopathy *low-medium intensity *Take at bedtime Ezetimibe I: high cholesterol Zetia (I,D,SE,adj) D: 10mg po qd *Caution: myopathy *Can be used w/ statin Niacin (B3) Niaspan = Extended release (Rx) I: TG >500 Niaspan ER, Niacor, Niacin (I,D,age,CI,SE,time,food) CI: peptic ulcer, bleeding W: ↑uric acid, ↑BG, myopathy/rhabdo if used w/ statin 500mg po QHS after lowfat snack ; pregnant/BF: 18mg daily (Max 2g/day; tolerability ↓ w/ doses >1gm - flushing/itching) *Taking WF helps with tolerability, slows absorption Colesevelam I: high cholesterol D: 6 tabs po qd Welchol (I,D,CI,SE) *CI: bowel obstruction *SE: constipation, gas, bloating (Welcol has less GI SEs) *OK w/ statins and hepatic disease *2nd line https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 17 of 54 Colestipol I: high cholesterol D: max 16g tab/d or 30g powder/d Colestid (I,D,CI,SE) *CI: bowel obstruction *SE: constipation, gas, bloating *OK w/ statins and hepatic disease *2nd line Cholestyramine I: high cholesterol Questran, Prevalite (I,CI,SE) *CI: bowel obstruction *SE: constipation, gas, bloating *OK w/ statins and hepatic disease *2nd line Gemfibrozil I: TG >500 CI: liver/renal/gallbladder disease Lopid (I,D,CI,SE,food) SE: rhabdomyolysis, myopathy *Avoid w/ statin D: 600mg po bid 30min before BF/dinner Fenofibrate I: high TG D: 145mg po qd Tricor, Triglide, TriLipix, Antara (I,D,CI,SE,food) *CI: liver/renal/gallbladder disease *SE: rhabdomyolysis, myopathy *Avoid w/ statin *Take w/ food Nitroglycerin SL tablet I: angina attack and prevention CI: PDE-5 inhibitors ͒ , riociguat SE: HA, flushing, tingling in mouth, hypotension, dizziness, syncope Nitrostat, Nitroquick (I,D,CI,SE,food) 0.3-0.6 mg q5m, max 3 doses in 15 min *call 911 if 1ˢᵗ dose does not relieve CP ͒avanifil in past 12H, sildenafil or vardenafil in past 24H or tadalafil in past 48H *Avoid alcohol Nitroglycerin spray (short acting) I: angina attack and prevention CI: PDE-5 inhibitors ͒, riociguat SE: HA, flushing, stinging in mouth, hypotension, dizziness, syncope *Don't shake NitroMist, Nitrolingual Pump Spray (I,D,CI,SE,food,set up) *Prime (5 sprays for Nitrolingual, 10 sprays for NitroMist) *Spray 1-2 (0.4mg) sprays onto or under tongue, do not inhale spray *Close mouth after spraying *Try not to swallow quickly or spit Max 3 doses in 15 min ͒avanifil in past 12H; sildenafil or vardenafil past 24H; tadalafil past 48H *Avoid alcohol https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 18 of 54 Nitroglycerin transdermal patch I: angina prevention (long acting NTG) CI: PDE-5 inhibitors Minitran, Nitro-Dur (I,D,CI,SE,food) SE: HA, flushing, hypotension, dizziness, syncope *Avoid alcohol 0.1-0.8mg/hr *Wear on for 12-14H, off for 10-12H, rotate sites, can be worn anywhere above knees (chest preferred) Nitroglycerin ointment 2% I: angina prevention (long acting NTG) CI: PDE-5 inhibitors SE: HA, flushing, hypotension, dizziness, syncope Nitro-BID (I,D,CO,SE) *Avoid alcohol Dosed BID (6H apart, with 10-12H nitrate-free interval) Measure dose with dosing applicator supplied with the tube. Apply to chest, or other desired area. Do not rub into the skin. Tape applicator into place. *Can stain clothing, cover completely Isosorbide mononitrate IR/ER tablet I: stable ischemic heart disease (long acting nitrate) Monoket, Imdur IR product: use BID, separated by 8H ER product: use QAM Nitroglycerin infusion D5W Low dose: venous dilator, high doses: arterial dilator I: Myocardial ischemia, uncontrolled HTN Tridil (I,D,CI,SE,food) CI: SBP <90, use w/ PDE-5 inhibitors or riociguat Warnings: severe hypotension, ↑ ICP SE: HA, tachycardia, tachyphylaxis w/i 24-48H of cont administration *Requires non-PVC container (glass, polyolefin) Isosorbide dinitrate (long acting) I: angina prevention, HF w/ hydralazine (BiDil) -Standard add-on in AA or ACEI/ARB intolerance d/t renal insufficiency, hyperkalemia, or hypotension CI: PDE-5 inhibitors (sildenafil, tadalafil) Isordil (I,D,CI,SE,food) SE: HA, flushing, hypotension, dizziness *Avoid alcohol Initial Dose: 10 mg po TID Target Dose: 40mg po TID Clopidogrel Med Guide I: ACS, recent MI/stroke; PAD or CAD to ↓ risk of clot, stable ischemic heart dz in ASA allergy BBW: Prodrug, converted to active metabolite by 2C19, test to check genotype & avoid in 2C19 poor metabolizers Plavix (I,D,SE,test,CI) *Avoid w/ omeprazole, esomeprazole SE: bleeding, bruising, pruritis W: ↑ risk of thrombosis is dc prematurely, TTP ACS: 300-600mg po LD MD: 75mg po daily https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 19 of 54 Ticagrelor I: ACS BBW: ASA maintenance doses >100mg ↓ effectiveness of ticagrelor (only use in ACS x1); avoid when CABG likely, stop 5 days before any surgery Brillinta LD: 180mg MD: 90 mg BID x1year, then 60mg BID *Tablets can be crushed & mixed w/ water to be swallowed or given via NG tube Major 3A4 substrate, avoid w/ strong inducers or inhibitors Prasugrel I: ACS in patients who are to be managed with PCI BBW: bleeding, do not initiate if CABG likely, stop 7 days prior to elective surgery CI: serious bleeding; h/o TIA or stroke Effient *Not recommended in pts >75 unless pt is high risk (prior MI, DM) LD: 60mg po no later than 1H after PCI MD: 10 mg po daily with ASA (5mg if wt<60kg) *Dispense in original container Ticlopidine Ticlid (I,D,SE) I: ACS, recent MI/stroke, PAD D: 250mg BID SE: bleeding, bruising, risk of neutropenia, hematopoietic d/o Abciximab (IV GP-IIb/IIIa inh) I: PCI only D: 0.25mg/kg bolus pre-PCI, then 0.125mcg/kg/min x 12hr Reopro (I,D,SE,ROA,storage) SE: thrombocytopenia, bleeding, hypotension *refrigerate *filter Eptifibatide I: ACS + PCI D: 180mcg/kg bolus, then 2mcg/kg/min x 25h Integrilin (I,D,ROA,SE,storage) *IV only *SE: thrombocytopenia, bleeding, hypotension *refrigerate *protect from light Dipyridamole Persantine (I,D,SE) I: TIA/stroke prevention D: 75-100mg po QID *SE: CP, HA, dizziness, angina exacerbation, abnormal ECG Aspirin/dipyridamole Aggrenox (I,D,SE) I: TIA/stroke prevention D: 25mg/200mg po BID *SE: HA, dyspepsia, N/D, bleeding Cilostazol Pletal (I,D) I: intermittent claudication D: 100mg po bid 30 min before or 2 hrs after meals x 3 months Pentoxifylline Trental (I,D) I: intermittent claudication D: 400mg po TID https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 20 of 54 Disopyramide I: Class 1a AAD: blocks Na/K channels, ventricular arrhythmias Norpace(I,SE,CI,food) W: hypotension, HF, BPH/urinary retention, glaucoma, myasthenia gravis (d/t anticholinergic effects) SE: ↑ QT interval, anticholinergic, hypotension *Take on empty stomach I: Class 1a AAD: arrhythmia BBW: ↑ mortality in AF/AFl; control AV conduction before initiating CI: FQs (QT prolongation), ritonavir, thrombocytopenia, TTP, myasthenia gravis W: hepatotoxicity, hemolysis (avoid in G6PD def), can cause + Coombs test Quinidex (Quinidine) (I,BBW,SE,food,DDI) SE: DILE, diarrhea, stomach cramping, cinchonism (overdose: tinnitus, hearing loss, blurred vision, delirium) *Take WF or milk to ↓ GI upset *DDI w/ digoxin (↓digoxin by 50%), warfarin, grapefruit and non-DHP CCBs I: Class 1a AAD: blocks Na/K channels, ventricular arrhythmias BBW: agranulocytosis (monitor closely in 1st 3 months & periodically thereafter); positive ANA which Pronestyl (Procainamide) (I,BBW,SE) can result in DILE; reserve for life-threatening ventricular arrhythmias SE: hypotension, rash Active metabolite NAPA is renally cleared, ↓ dose when CrCl <50 *Th. Range: 4-10 mcg/mL Lidocaine I: Class 1b AAD: refractory VT/cardiac arrest Xylocaine (I,DDI,monitor) CI: allergy to corn W: Caution in elderly & pts w/ HI or HF *Monitor LFTs *DDI that ↑ lidocaine: amiodarone, BB, non-DHP CCBs, grapefruit, macrolides, etc Amiodarone Med Guide I: Class III AAD: blocks K channels; broad spectrum (Safe in HF and post MI) BBW: pulmonary toxicity, hepatotoxicity. Use only for life-threatening arrhythmias d/t toxicities. Patients should be hospitalized when loading dose is given. CI: iodine hypersensitivity W: Thyroid (hypo more common), optic neuropathy, photosensitivity (blue skin discoloration), Cordarone, Nexterone (I,D,SE,monitor,food) peripheral neuropathy, SJS SE: hypotension, bradycardia, corneal microdeposits, dizziness, ataxia, constipation, tremor, DILE M: ECG, BP, HR, e-lytes, pulm (X-ray) at BL & annually, LFTs at BL & Q6months, TSH at BL & Q36months, eye exams *Avoid in pregnancy/BF *Non-PVC container for infusions >2H (PVC tubing is ok). 0.22micron filter. Incompatible w/ heparin (flush line) *3A4/P-gp substrate; mod 2C9/2D6 inhibitor | When starting amio, ↓digoxin 50% & ↓warfarin 30-50% | max 20mg simva & 40mg lovastatin | do not use w/ sofosbuvir d/t bradycardia Sotalol I: Class III AAD: AF/AFl BBW: Initiate/↑dose in hospital w/ cont ECG monitoring; CrCl determines dosing interval→ QT Betapace (I,D,SE) prolongation ∝ concentration CI: QTc >450 msec, bronchospastic condition, CrCl <40, K <4 SE: bradycardia, fatigue, bronchoconstriction, HF D: 160mg po bid; CrCl <60: ↓frequency https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 21 of 54 Digoxin I: add-on for HF, AF W: vesicant - avoid extravasation SE: dizziness, mental disturbances M: ECG, BP, e-lytes, renal fxn, digoxin lvl (drawn 12-24H after dose) Toxicity: Initial= N/V, loss of appetite, bradycardia. Severe= blurred/double vision, greenish-yellow halos, confusion, delirium, prolonged PR intervals, arrhythmias ↓K, ↓Mg, ↑Ca : ↑risk of dig toxicity *K+ 4-5 to avoid toxicity Lanoxin, Digitek (I,W,SE,Tox,D) *Antidote: Digibind or DigiFab 125-250 mcg po daily *CrCl <50: ↓ dose or frequency. *Th. Range, HF: 0.5-1 | AF: 0.8-1.2 *↓ dose by 25% when going from po→IV *(+) inotrope, (-) chronotrope P-gp substrate, inhibitors ↑ Dig levels: amiodarone, dronedarone, quinidine, verapamil, erythromycin, clarithromycin, itraconazole, propafenone & many others. ↓dig dose 50% w/ amio or dronedarone. Isotrentinoin Med Guide, iPLEDGE REMS Accutane, Absorica, Amnesteem, Claravis, Myorisan, Sotret, Zenatane (I,BBW,SE) I: severe acne BBW: pregnancy (2 forms of BC, informed consent) *No pregnancy one month before, during & x1 month after tx *Full effect in 3-5 months *SE: dryness Permethrin 5% (Rx) Elimite (I,application) I: head lice, scabies *May repeat in 7 days after initial application Permethrin 1% Nix (I,application) I: head lice *OTC for >1 yoa *May repeat in 7 days after initial application Calcium acetate Phoslyra, Phoslo, Calphron (I,D,SE) I: control of hyperphosphatemia (ESRD on dialysis) D: 1334mg w/ meal SE: GI effects, hypercal Sevelamer I: Hyperphosphatemia (occurs as CKD progresses, & contributes to ↑ PTH which can lead to bone dz/fractures) Renagel, Renvela (I,CI,W,M,D) CI: bowel obstruction Warnings: can ↓ dietary absorption of vits D, E, K and folic acid; consider supplementation Monitor: Ca, PO4, HCO3, Cl, PTH D: 800-1,600mg po TID WF, titrate based on PO4 levels Lanthanum MedGuide: Warning for GI obstruction, sev. constipation I: ↓ serum phosphorus (CKD) Fosrenol (I,D,SE) SE: N/V/D, stomach pain 1500 mg QD (upto 4500mg) with or right after meals Chewable tablets Oral powder - sprinkle on applesauce or similar (does not dissolve in liquids) https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 22 of 54 Cinacalcet: ↑Ca-receptor sensitivity of parathyroid gland: ↓PTH, ↓Ca, ↓PO4 I: Hyperparathyroidism in dialysis pts, parathyroid carcinoma CI: Hypocalcemia Sensipar (I,CI,W,SE,M,D) Warnings: Caution if h/o seizures SE: hypocalcemia, paresthesia, myalgia M: Ca, PO4, PTH D: 30-180mg po daily WF Amphojel, DermaMed (I) TUMS (I) Aluminum hydroxide I: antacid, skin protectant Calcium carbonate I: antacid Calcitriol (Vit D3) Rocaltrol (I,SE) I: hypocalcemia in hypoparathyroidisim, 2ndary hyperparathyroism in CKD SE: excessive vit D, hypercal Drisdol (I) Ergocalciferol (Vit D2) I: hypoparathyroidism Levothyroxine (T4) I: hypothyroidism; myxedema coma (IV) D: 1.6 mcg/kg/day (IBW) with water 60min before BF or QHS (3H after last meal) *If CAD: start 12.5-25mcg QD Euthyrox, Levoxyl, Synthroid, Tirosint, Unithroid (I,D, BBW, CI, SE) BBW: thyroid supplements are ineffective & potentially toxic when used for obesity or weight loss, esp. if euthyroid; high doses ↑ risk of serious or life-threatening effects esp. with anorectic drugs (e.g. sympathomimetic amines) CI: uncorrected adrenal insufficiency SE: ↓BMD; If dose too high: ↑HR, palpitations, sweating, wt loss, arrhythmias, irritability Thyroid desiccated *Natural porcine-derived thyroid with both T3 & T4 *Not preferred, but some feel better using it Armour Thyroid BBW: thyroid supplements are ineffective & potentially toxic when used for obesity or weight loss, esp. if euthyroid; high doses ↑ risk of serious or life-threatening effects esp. with anorectic drugs (e.g. sympathomimetic amines) CI: uncorrected adrenal insufficiency SE: ↓BMD; If dose too high: ↑HR, palpitations, sweating, wt loss, arrhythmias, irritability Liothyronine (T3) I: hypothyroidism; myxedema coma (but IV levothyroxine preferred) D: PO 25mcg QD (25-75 mcg QD maintenance) Cytomel, Triostat (BBW,I,D) BBW: thyroid supplements are ineffective & potentially toxic when used for wt loss, esp. if euthyroid; high doses ↑ risk of serious or life-threatening effects esp. with anorexants (e.g. sympathomimetic amines) CI: uncorrected adrenal insufficiency SE: ↓BMD; If dose too high: ↑HR, palpitations, sweating, wt loss, arrhythmias, irritability Methimazole I: hyperthyroidism D: 5mg po Q8H Tapazole (I,D, BBW,SE) SE: GI upset, drug-induced lupus erythematosus, hepatitis, agranulocytosis, taste perversion BBW: PTU preferred over methimazole in 1ˢᵗ trimester of pregnancy (↑risk of fetal abnormalities from methimazole) Methimazole often recommended for 2ⁿᵈ & 3ʳᵈ trimesters (d/t ↑risk of liver toxicity from PTU) https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 23 of 54 Propylthiouracil MedGuide I: hyperthyroidism, thyroid storm D: 50-150mg po Q8H PTU (BBW,I,D,SE) SE: GI upset, drug-induced lupus erythematosus, hepatitis, agranulocytosis, taste perversion BBW: hepatotoxicity; preferred in 1ˢᵗ trimester of pregnancy (↑risk of fetal abnormalities from methimazole) Methimazole often recommended for 2ⁿᵈ & 3ʳᵈ trimesters (d/t ↑risk of liver toxicity from PTU) Mesalamine (5-ASA) Canasa: Suppository (retain ≥1-3H) Rowasa: Enema (retain ≥30min) Canasa Asacol HD, Lialda: ER tabs Rowasa Asacol HD, Lialda Apriso, Delzicol, Pentasa (I, formulations) Apriso, Delzicol, Pentasa: ER caps I: ulcerative colitis, induction tx for acute flares, and maintenance Counseling: suppositories/enemas stain fabric, flooring, painted surfaces, marble, granite, vinyl & enamel Imodium Loperamide Diphenoxylate/atropine, CV Lomotil I: Diarrhea D: 1-2 tab QID AC Pepto-Bismol Bismuth subsalicylate Kaopectate Bismuth subsalicylate Metamucil Psyllium Nujol Milk of Magnesia (I) Miralax (I) Glycolax Mineral oil Magnesium hydroxide I: antacid, laxative Polyethylene glycol I: constipation Polyethylene glycol Pramlintide (SQ) SymlinPen 120, SymlinPen 60 (BBW,I) MedGuide BW: hypoglycemia I: T1DM, T2DM Lactulose Constulose, Enulose, Gemnerlac, Kristalose (I,D) I: constipation, portal systemic encephalopathy, overt heapatic encephalopathy D: 16.7g (25mL) Q1-2h until at least 2 loose stools, titrate to 2-3 bowel movements Bisacodyl Dulcolax (I,D) I: Bowel cleansing (enema only), constipation D: PO 5-15mg QD; rectal 1 enema QD Exlax, Senokot, (I) https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY Senna I: constipation 1/7/24, 6:06 PM Page 24 of 54 Docusate sodium (PO/rectal) Colace (I,ROA,D) I: stool softener D: PO 240mg QD; rectal 1 enema QD-TID Metformin [Biguanide] Max PO: 2g - 2.55g per day SE: lactic acidosis, VitB12 deficiency Glucophage, Glumetza, Fortamet, Riomet CI: eGFR<30, acute or chronic metabolic acidosis (includes DKA) BBW: lactic acidosis *Take WITH FOOD to ↓GI sxs Glipizide (PO) [SU] PO IR: 5mg 30min before BF (max 40mg/d); doses >15mg should be divided BID Glucotrol PO XL: 5mg with BF (max 20mg/d) SE: hypogly, weight gain, hemolytic anemia in G6PD deficiency CI: DKA, sulfa allergy Glyburide (PO) [SU] D: 2.5-5mg with BF (max 20mg/d) SE: hypogly, weight gain, hemolytic anemia in G6PD deficiency Micronase, Diabeta, Glynase CI: DKA, sulfa allergy On Beers List Renal elimination of active metabolite Glimepiride (PO). [SU] D: 1-2mg with BF (max: 8mg/d) SE: hypogly, weight gain, hemolytic anemia in G6PD deficiency Amaryl (I,D,SE) CI: DKA, sulfa allergy On Beers List XL Formulation - OROS system - ghost cap Nateglinide (PO) [Meglitinide] Starlix D: 60-120mg TID 1-30 min before meals SE: hypogly, weight gain Repaglinide (PO) [Meglitinide] D: 0.5-2 mg 15-30 min before each meal (TID AC) Prandin Max: 16mg/day SE: hypogly, weight gain CI: concurrent use of gemfibrozil Pioglitazone [TZD -PPARgamma agonist] D: 15-30mg QD (max 45mg/d) Actos (BBW,I,D,SE) Med Guide BBW: Can cause or exacerbate HF CI: NYHA Class III/IV HF SE: bladder cancer, edema, weight gain, fractures, hepatotoxicity https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 25 of 54 Canagliflozin [SGLT2 inhibitor] D: 100mg before BF (max 300mg/d) Med Guide BBW: ↑ risk of amputations Invokana CI: eGFR<30, ESRD or dialysisterm SE: AKI, UTI, keto acidosis, weight loss, ↑ urinary frequency, volume depletion, thirst, hypotension, ↑ LDL, fractures, hyperkalemia ↓ CV risk in pts with T2DM & ASCVD Rosiglitazone (TZD) Med Guide I: T2DM, ↓A1c 0.5-1.5% Avandia (BBW,I,D,SE) BBW: Can cause/exacerbate HF, ↑ risk of MI CI: NYHA Class III/IV HF SE: edema, weight gain, HF, fractures, hepatotoxicity, ovulation in premenopausal women D: 4-8mg QD (max 8mg/d) Dapagliflozin [SU] D: 5mg QAM (max 10 mg/d) Farxiga Med Guide CI: eGFR<30 SE: AKI, UTI, ketoacidosis, weight loss, ↑ urinary frequency, volume depletion, thirst, hypotension, ↑ LDL, risk of bladder cancer Empagliflozin [SU] D: 10 mg QAM (max 25 mg/d) Med Guide Jardiance CI: eGFR<30 SE: AKI, UTI, DKA, weight loss, ↑ urinary frequency, volume depletion, thirst, hypotension, ↑ LDL ↓ CV risk in pts with T2DM & ASCVD Sitagliptin [DPP4 inhibitor] Med Guide T2DM, ↓A1c 0.5-0.8% Januvia Warnings: Acute pancreatitis, arthralgia SE: peripheral edema *CrCl 30-49: 50mg; CrCl <30: 25mg Saxagliptin [DPP4 inhibitor] T2DM, ↓A1c 0.5-0.8% Onglyza W: Acute pancreatitis, arthralgia, risk of HF SE: peripheral edema 2.5-5mg po QAM (eGFR <45: 2.5 mg daily) Linagliptin [DPP4 inhibitor] T2DM, ↓A1c 0.5-0.8% Tradjenta W: Acute pancreatitis, arthralgia SE: peripheral edema 5mg po QAM (no renal dose adj.) https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 26 of 54 Alogliptin T2DM, ↓A1c 0.5-0.8% Nesina W: Acute pancreatitis, arthralgia, HF, hepatotoxicity SE: peripheral edema 25mg po QAM (CrCl 30-59: 12.5mg; CrCl <30: 6.25mg) Exenatide [GLP1 agonist] Med Guide T2DM, ↓A1c 0.5-1.5% Warnings: pancreatitis; avoid in severe GI dz, including gastroparesis Byetta SE: nausea, weight loss D: 5 mcg SC BID within 60 min meals x1month; can ↑ to 10 mcg SC BID *Discard pen after 30days *ESRD or CrCl <30: not recommended Exenatide [GLP1 agonist] Med Guide T2DM, ↓A1c 0.5-1.5% BBW: risk of thyroid C-cell carcinomas Bydureon, Bydureon BCise CI: personal or family h/o thyroid cancer or multiple endocrine neoplasia (MEN2) Warnings: pancreatitis; avoid in severe GI dz, including gastroparesis SE: nausea, weight loss, serious injection-site rxns D: 2mg SC once weekly ESRD or CrCl <30: not recommended Liraglutide [GLP1 agonist] Med Guide T2DM (↓A1c 0.5-1.5%), ↓ CV risk in diabetics with ASCVD BBW: risk of thyroid C-cell carcinomas CI: personal or family h/o thyroid cancer or multiple endocrine neoplasia (MEN2) Victoza Warnings: pancreatitis; avoid in severe GI dz, including gastroparesis SE: nausea, weight loss Stable at room temp x30 days D: 0.6 mg SC daily x1week, then 1.2 mg SC daily; can ↑ to 1.8 mg SC daily Saxenda for weight loss Dulaglutide Med Guide T2DM, ↓A1c 0.5-1.5% BBW: risk of thyroid C-cell carcinomas Trulicity CI: personal or family h/o thyroid cancer or multiple endocrine neoplasia (MEN2) Warnings: pancreatitis; avoid in severe GI dz, including gastroparesis SE: nausea, weight loss D: 0.75mg SC once weekly, can ↑ to 1.5mg SC once weekly Lixisenatide T2DM, ↓A1c 0.5-1.5% W: pancreatitis; avoid in severe GI dz, including gastroparesis Adlyxin (I, W, SE, D) SE: nausea, weight loss 10mcg SC daily within 60min before BF x14days then ↑ to 20mcg daily eGFR <15: not recommended https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 27 of 54 Acarbose (PO) I: T2DM Precose (I,D) D: 25mg TID with the first bite of each meal (max 100mg TID) Glucose tablets req'd to treat hypoglycemia; cannot be treated with sucrose (table sugar, fruit juice, candy) Miglitol (PO) I: T2DM Glyset (I,D) Glucose tablets req'd to treat hypoglycemia; cannot be treated with sucrose (table sugar, fruit juice, candy) D: 25mg TID with first bite of each meal (max 100mg TID) Lispro (rapid acting insulin ) *Give up to 15min before or immediately after meals Humalog, Admelog Onset: ~15 min Peak: ~1H DOA: 2-3H Refrigerate; stable at room temp for 28 days Aspart (rapid acting insulin) *Give up to 15min before or immediately after meals Novolog, Fiasp Onset: 10-30min Peak: 0.5-3H DOA: 3-5H Apidra Glulisine (rapid acting) **** Regular insulin (short-acting) I: T1DM, T2DM (SQ) Give 30 min before meals Humulin R *Insulin of choice for IV solutions, including TPN *Available without Rx Onset: 15-30 min Peak: 2.5-5H DOA: 4-12H Regular insulin (short-acting) Novolin R Onset: 15-30 min Peak: 2.5-5H DOA: 4-12H NPH (intermediate acting insulin) *Cloudy appearance *Can mix with rapid or short acting insulins, draw up rapid or short acting insulin first (clear before cloudy) Novolin N *Available without Rx Onset: 1-2H Peak: 4-12H DOA: 14-24H https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 28 of 54 NPH (intermediate acting insulin) *Cloudy appearance *Can mix with rapid or short acting insulins, draw up rapid or short acting insulin first (clear before cloudy) Humulin N *Available without Rx Onset: 1-2H Peak: 4-12H DOA: 14-24H Glargine -long acting insulin *acidic pH: can sting upon injection *Do not mix with other insulins Lantus, Toujeo, Basaglar Onset: 3-4H (Toujeo: 6H) Peak: N/A DOA: ≥24H Detemir -long acting insulin *If given once daily, dose with evening meal or qhs *Do not mix with other insulins Levemir (I,D,SE) Onset: 3-4H Peak: N/A DOA: 6-23H (dose-dependent) Colchicine (PO) Med Guide Colcrys, Gloperba, Mitigare (I,D) I: Gout Ppx: 0.6mg QD-BID (max 1.2mg/d) Tx: 1.2mg at first sign of flare, in 1H 0.6mg (max 1.8mg on day 1), then 0.6mg QD-BID until flare resolves Allopurinol - XO inhibitor, ↓ UA production I: Chronic management of gout (ppx of future attacks) W: HLA-B*5801 testing in Asians: ↑risk of SJS; BM suppression, hepatotoxicity SE: Rash, acute gout attacks, nausea, diarrhea, ↑LFTs Aloprim, Zyloprim (I,W,SE,D) Start: 100mg po once daily after a meal (to ↓nausea) ↑by 100mg/day q2-5wks until UA <6mg/dL *doses >300mg should be divided BID *max 800mg/day Ppx for acute gout flares (NSAIDs or colchicine) recommended for first 3-6 months Probenecid I: Gout: ↑ uric acid excretion W: Precipitates acute gout (Colcrys/NSAID x3-6months); avoid in G6PD deficiency 250mg po BID x 1-2wks f/b 500mg BID (max 2g/d) Benemid (I,D) *Avoid in CrCl <50 Probenecid ↓ renal CL of other meds: - Beta lactams: PCNs/Cephs/Carbapenems - Methotrexate - Salicylates https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 29 of 54 Gels: apply at same time each morning; flammable until dry. ⋄1% - upper arms, shoulders and/or abdomen ⋄1.62% should only be applied to upper arms or shoulders (not the abdomen) AndroGel BBW: secondary exposure to testosterone in children can occur causing virilization; children should avoid contact w/ any unwashed or unclothed application sites CI: breast/prostate cancer, pregnancy, breast-feeding W: ↑ risk of breast/prostate ca, CV events, VTE, dyslipidemia, gynecomastia HI, priapism, may worsen BPH SE: ↑ appetite, ↑ Scr, sensitive nipples, acne, edema, hepatotoxicity, ↓ sperm count Alendronate Med Guide Fosamax, Binosto (I,D,SE) I: osteoporosis D: PO 70mg Qwkly or 10mg Qd (TX); PO 35mg Qwkly or 5mg QD (prevention) Bone fractures, bone/joint/muscle pain, GI irritation, hypocal, ocular effects, ONJ Ibandronate (PO/IV) MedGuide I: Osteoporosis in postmenopausal females Boniva (food,I,D,SE) SE: bone fx, bone/joint/muscle pain, GI irritation, ↓Ca , ONJ 150mg po once monthly or 3mg IV q 3 months *take in upright position with full glass water, avoid lying down for 60 min (↓GI effects) Zoledronic acid MedGuide I: Osteoporosis ppx/tx (Reclast); Zometa, Reclast (IV) (I;D;SE) Hypercalcemia of malignancy (Zometa) SE: bone fx, ↓Ca, MSK pain, ocular infection, ONJ Reclast: Ppx: 5mg IV q 2 years; Tx: 5mg IV every year Zometa: IV 4mg Q3-4wks (Zometa) Risedronate Med Guide I: osteoporosis 5mg daily or 35mg weekly or 150mg monthly Actonel, Atelvia (I,D) Atelvia (delayed release risedronate) requires an acidic gut for absorption; H2RAs and PPIs should be avoided completely *Only oral bisphosphonate formulation that should be taken immediately after BF (only available as 35mg, once weekly) Raloxifene: SERM MedGuide I: tx/ppx of osteoporosis in postmenopausal women; breast cancer prophylaxis in postmenopausal Evista (BW,I,D) women BBW: ↑VTE risk CI: h/o DVT/PE SE: hot flashes, night sweats, viginal spotting/dryness, ↓ libido, ↓BMD (Ca/vit D supp) D: 60mg po QD Miacalcin, Fortical nasal spray (I) Calcitonin I: hypercal, postmenopausal osteoporosis Yaz, Yasmin, Gianvi, Jasmiel, Loryna, Nikki, Ocella, Syeda, Zarah, Estrogen/progestin Zumandimine (BW) BW: smoking+ CV events https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 30 of 54 Levonorgestrel Plan B (I,D) I: emergency contraception D: 2 dose regimen= 0.75mg ASAP within 72H, then 0.75mg 12H after 1st dose; 1 dose regimen= 1.5mg ASAP within 72H Ulipristal Ella (I,D) I: emergency contraception D: 30mg ASAP, but within 120H (5 days) Premphase, Prempro (BW) Premarin (BW) Alora, Climara, Delestrogen, Divigel, Dotti, Elestrin, Estrace, Evamist, Femring, Minivelle, Vivelle-dot (BW) Provera, depo-provera (BW) Conjugated estrogens BW: endometrial cancer, CV disease, breast cancer, dementia Conjugated estrogens BW: endometrial cancer, CV disease, breast cancer, dementia Estradiol BBW: endometrial cancer, CV disease, breast cancer, dementia I: vasomotor sx of menopause including hot flashes & night sweats Medroxyprogesterone BW: CV disorders (DVT/PE, stroke, MI), breast cancer, dementia, bone loss) Cetirizine Zyrtec (I,D) I: allergic rhinitis/conjunctivitis, uritcaria D: 10mg QD Levocetirizine Xyzal (I,D) I: chronic idiopathic uritcaria, allergic rhinitis D: 5mg QD (PM) (upto 10mg BID) Loratadine Claritin (I,D) I: allergic rhinitis, uritcaria D: 10mg QD or 5mg BID Desloratadine Clarinex (I,D) I: chronic itiopathic urticaria, allergic rhinitis D: 5mg QD Fexofenadine Allegra (I,D) I: upper resp. allergy D: 60mg BID (max 120mg/d) or 180mg QD Diphenhydramine (PO/IM/IV) Benadryl (I,D) I: allergy, cold, motion sickness, uritcaria D: 25mg Q4-6H or 50mg Q6-8H Chlorpheniramine (OTC) Chlor-Trimeton (I,S,SE) I: 1st Gen Anti-HM: allergy, urticaria/pruritus, N/V, motion sickness D: IR 4mg Q4-6H; ER 12mg Q12H (max 24mg/24H) SE: CNS depression Hydroxyzine pamoate (PO/IM) Vistaril (I,D,SE,ROA) I: antiemetic, anxiety, pruritis, hives D: IM 25-100mg/d SE: CNS depression, QT risk https://quizlet.com/521646510/cg-cpje-top-400-drugs-training-wheel-flash-cards/?i=fhqjq&x=1jqY 1/7/24, 6:06 PM Page 31 of 54 Hydroxyzine HCl (IM/PO) Atarax (ROA,I,D,SE) I: antiemetic D: Im 25-100mg/d SE: CNS depression, QT risk Promethazine (PO/IM/IV) I: allergies, motion sickness, N/V, sedation Phenergan, Phenadoz, Promethegan (ROA,BW,I,D) BBW: resp depression, severe tissue injury (inj) CI: children <2yo D: 25mg QHS or 12.5mg before meals and at bedtime Pseudoephedrine (PO) Sudafed (I,D,max) I: nasal congestion D: IR 60mg Q4-6H; ER 120mg Q12H or 240mg Q24H (max) 3.6g/d limit or 9g/month limit Famotidine I: GERD Tablets/Oral Suspension/IV solution Pepcid (I,D,SE) SE: B12 def w/ prolonged use, HA, dizziness, drowsiness OTC: 10 mg po BID prn Rx: 20 mg po BID x 6 wks Ranitidine Zantac (I,D) I:GERD D: 75mg BID prn (upto 150mg BID for