Advanced Medicinal Chemistry Past Paper PDF - GUJARAT TECHNOLOGICAL UNIVERSITY - Winter 2023

Seat No.: _____ Enrolment No. _____________ GUJARAT TECHNOLOGICAL UNIVERSITY M. Ph.. - SEMESTER– I EXAMINATION – WINTER -2023 Subject Code: MPC103T Date: 16/01/20...

Seat No.: _____ Enrolment No. _____________ GUJARAT TECHNOLOGICAL UNIVERSITY M. Ph.. - SEMESTER– I EXAMINATION – WINTER -2023 Subject Code: MPC103T Date: 16/01/2024 Subject Name: Advanced Medicinal Chemistry Time: 2:30 PM to 5:30 PM Total Marks: 80 Instructions: 1. Attempt any five questions. 2. Make suitable assumptions wherever necessary. 3. Figures to the right indicate full marks. Q.1 (a) Write various theories of drug receptor interaction. 06 (b) Discuss about the different approaches in lead discovery prior to drug discovery. 05 (c) Write a note on various biological targets. 05 Q.2 (a) Give an account of design of prodrugs to improve patient acceptability. 06 (b) Write a note on the utilization of changes in ring size and alteration of chain 05 branching approach in analog design. (c) Brief out the types of bioisosters and bioisosteric replacement approach. 05 Q.3 (a) Write down importance of stereochemistry on drug design. 06 (b) Write SAR of H1 receptor antagonists. 05 (c) Write a note on antiviral agents. 05 Q.4 (a) Discuss briefly about the design and types of non-covalently binding enzyme 06 inhibitors. (b) Briefly explain about the aspect of enzyme kinetics. 05 (c) Write short note on enzyme inhibitors in medicine. 05 Q.5 (a) Explain the techniques used in peptidomimetic design. 06 (b) Write a note on therapeutic values of peptidomimetics. 05 (c) Write a note on modification of peptide back bone. 05 Q. 6 (a) Classify antihypertensive agents with suitable examples. 06 (b) Write SAR of anticonvulsant drugs. 05 (c) Brief out the chemistry of prostaglandins with emphasis to the drugs used in 05 therapy. Q.7 (a) Write down strategies to combat drug resistance in antibiotics and anticancer 06 therapy. (b) Write a note on enantioselectivity on pharmacokinetics. 05 (c) Write a note on artificial enzymes. 05 *************** Seat No.: _____ Enrolment No. _____________ GUJARAT TECHNOLOGICAL UNIVERSITY M. Pharm.- SEMESTER–I EXAMINATION – WINTER -2022 Subject Code: MPC103T Date: 05/04/2023 Subject Name: ADVANCED MEDICINAL CHEMISTRY Time: 02:30PM TO 05:30PM Total Marks: 80 Instructions: 1. Attempt any five questions. 2. Make suitable assumptions wherever necessary. 3. Figures to the right indicate full marks. Q.1 (a) Write down various theories of drug receptor interaction. 06 (b) Discuss recent advances of anti-viral agents. 05 (c) Write down chemistry of Prostaglandins in details. 05 Q.2 (a) Define Drug Discovery. Discuss various stages of drug discovery. 06 (b) Discuss about strategies to combat drug resistance in antibiotics. 05 (c) Define anti-hypertensive agents. Discuss SAR of ACE inhibitors. 05 Q.3 (a) Discuss genetic principles of drug resistance. 06 (b) Write a note on artificial enzymes. 05 (c) Define Peptidomimetics. Write down therapeutics values of Peptidomimetics. 05 Q.4 (a) Define Bio-isosterism. Write down classification of Bio-isosters. Discuss 06 bioisosteric replacement strategies. (b) Explain the principle of Enzyme inhibitors. Discuss therapeutic uses of Enzyme 05 inhibitors. (c) Write a note on lead discovery. 05 Q.5 (a) Write about enantio selectivity in drug adsorption, metabolism, distribution and 06 elimination in briefs. (b) Discuss SAR & Classification of Sympathomimetic agents. 05 (c) Explain role of chirality in selective and specific therapeutic agents with 05 suitable examples. Q. 6 (a) Define Prodrug. Write about Prodrug to improve drug solubility, absorption, 06 distribution and acceptability. (b) Write a note of Anticonvulsant agents in details. 05 (c) Discuss design of Peptidomimetics in details. 05 Q.7 (a) Write down rational design of non-covalently and covalently binding enzyme 06 inhibitors. (b) Explain chemistry and therapeutics uses of Leukotriene in details. 05 (c) Write down SAR of H1 antagonist. Write down synthesis of Cetrizine. 05 ***************  Seat No.: _____ Enrolment No. _____________ GUJARAT TECHNOLOGICAL UNIVERSITY M. Ph. – SEMESTER I– EXAMINATION – WINTER -2021 Subject Code: MPC103T Date: 15/03/2022 Subject Name: ADVANCED MEDICINAL CHEMISTRY Time: 10:30AM to 01:30PM Total Marks: 80 Instructions: 1. Attempt any five questions. 2. Make suitable assumptions wherever necessary. 3. Figures to the right indicate full marks. Q.1 (a) Define prodrugs and focus on rationale and practical consideration of prodrug design. 6 (b) Define: (i) Receptors (ii) Drugs (iii) Medicines (iv) Antagonists (v) Biosiosterism. 5 (c) Define the terms and give example of one drug from each class: (i) Anti-hypertensive drugs 5 (ii) Psychoactive drugs (iii) Anticonvulsant drugs (iv) H1 & H2 receptor antagonist (v) Cholinergic agents. Q.2 (a) Focus on mode of action of COX1 & COX2 inhibitors. 6 (b) Write SAR of Psychoactive drugs. 5 (c) Write role of chirality in selective and specific therapeutic agents. 5 Q.3 (a) Focus on Stereochemistry and Drug action. 6 (b) Write short note on peptidomimetics. 5 (c) Discuss about enzyme kinetics & principles of enzyme inhibitors. 5 Q.4 (a) Discuss about genetic principles of drug resistance. 6 (b) Focus on analog design. 5 (c) Focus on biological drug targets. 5 Q.5 (a) Discuss about rational drug design. 6 (b) Write SAR of H1 & H2 receptor antagonist. 5 (c) What is nitrogen mustard and focus on its mode of action. 5 Q.6 (a) Write SAR of anticholinergic drugs. 6 (b) Write in brief account on lead identification in drug discovery. 5 (c) Classify antiviral drugs with examples and their mode of action. 5 Q.7 (a) Write a short note on artificial enzymes. 6 (b) Explain theories of drug receptor interaction. 5 (c) Focus on strategies to combat drug resistance in antibiotics and anticancer therapy. 5 Seat No.: _____ Enrolment No. _____________ GUJARAT TECHNOLOGICAL UNIVERSITY M.PHARM - SEMESTER–1 EXAMINATION – WINTER-2019 Subject Code: MPC103T Date: 01/01/2020 Subject Name: Advanced Medicinal Chemistry Time: 02:30 PM TO 05:30 PM Total Marks: 80 Instructions: 1. Attempt any five questions. 2. Make suitable assumptions wherever necessary. 3. Figures to the right indicate full marks. Seat No.: ________ Enrolment No.______________ GUJARAT TECHNOLOGICAL UNIVERSITY M.PHARM – SEMESTER -1 - EXAMINATION –WINTER - 2018 Subject Code: MPC103T Date: 05/01/2019 Subject Name: Advanced Medicinal Chemistry Time :10:30 AM TO 01:30 PM Total Marks: 80 Instructions: 1. Attempt any five questions. 2. Make Suitable assumptions wherever necessary. 3. Figures to the right indicate full marks. Q.1 (a) Enumerate stages of drug discovery and explain methods of lead discovery. 06 (b) Explain the theories involved in drug receptor interaction. 05 (c) Why we required lead optimization? Explain methods involved in lead 05 optimization. Q.2 (a) Add a note on rational behind prodrug design. 06 (b) Explain strategies to combat drug resistance in antibiotics therapy. 05 (c) Why is cancer so difficult to cure? Explain with drug resistance. 05 Q.3 (a) Why analog design important in drug design? Explain any one strategy 06 involved in analog design. (b) Write recent advancement in anticancer agents. 05 (c) Why stereochemistry is important in drug action? 05 Q.4 (a) Explain the strategies involved in development antiviral agents. 06 (b) Explain enzyme kinetics & principles of enzyme inhibitors. 05 (c) Add a note on enzyme inhibitors in basic research. 05 Q.5 (a) Explain design of peptidomimetics. 06 (b) Explain chemistry of prostaglandins, leukotrienes and thromboxanes. 05 (c) Add a note on identification, validation and diversity of drug targets. 05 Q. 6 (a) Explain latest development of antihypertensive medication. 06 (b) Add a note on carrier linked prodrugs. 05 (c) Explain simplification approach in lead optimization 05 Q.7 (a) Explain non-covalently and covalently binding enzyme inhibitors. 06 (b) Add a note on COX-1 & COX-2 inhibitors. 05 (c) Explain H1 & H2 receptor antagonists. 05 *************** Seat No.: _____ Enrolment No. _____________ GUJARAT TECHNOLOGICAL UNIVERSITY M.PHARM SEMESTER-1 EXAMINATION – SUMMER-2024 Subject Code: MPC103T Date: 13/06/2024 Subject Name:Advanced Medicinal Chemistry Time: 02:30 PM TO 05:30 PM Total Marks:80 Instructions: 1. Attempt any five questions. 2. Make suitable assumptions wherever necessary. 3. Figures to the right indicate full marks. Q.1 (a) Enlist stages of drug discovery and explain methods of lead identification. 06 (b) Why we required lead optimization? Explain method target interaction involved 05 in lead optimization. (c) Discuss the theories involved in drug receptor interaction. 05 Q.2 (a) Why analog design important in drug design? explain any one strategy involved 06 in analog design. (b) Write methods involved in identification, validation and diversity of drug 05 targets. (c) Enumerate and discuss rational behind prodrug design. 05 Q.3 (a) Discuss bipartite prodrug with suitable examples. 06 (b) Add a note on enzyme inhibitors in basic research. 05 (c) Discuss enzyme inhibitors in medicine 05 Q.4 (a) Discuss about enzyme kinetics & principles of enzyme inhibitors. 06 (b) Classify antiviral drugs with examples and their mode of action. 05 (c) Explain enantio selectivity in drug adsorption, metabolism, distribution and 05 elimination Q.5 (a) Focus on strategies to combat drug resistance in antibiotics and anticancer 06 therapy. (b) Add a note on COX-1 & COX-2 inhibitors. 05 (c) Explain and differentiate Adrenergic & Cholinergic agents 05 Q. 6 (a) Classify anti-hypertensive agents and explain ACE inhibitors 06 (b) Write a note on Histamine receptor location and antagonist 05 (c) Write a note on alkylating agent and antibiotics used in cancer treatment 05 Q.7 (a) Enumerate type of Peptidomimetics and discuss any one 06 (b) Explain term i) Bioisosterism ii) Bioprecursor Prodrug 05 (c) Explain chemistry of prostaglandins, leukotrienes and thromboxanes. 05 *************** Seat No.: _____ Enrolment No. _____________ GUJARAT TECHNOLOGICAL UNIVERSITY M.Pharm- Sem–I EXAMINATION – SUMMER-2022 Subject Code:MPC103T Date:07/09/2022 Subject Name: Advanced Medicinal Chemistry Time: 10:30 AM TO 01:30 PM Total Marks: 80 Instructions: 1. Attempt any five questions. 2. Make suitable assumptions wherever necessary. 3. Figures to the right indicate full marks. Q.1 (a) Explain therapeutic value of peptidomimetics and its design 06 (b) Give the rational design of non-covalently and covalently binding 05 enzyme inhibitors (c) Explain chemistry of prostaglandins, leukotrienes and thromboxones. 05 Q.2 (a) Add a note on enzyme inhibitors in basic research 06 (b) Explain the Michaelis Menten equation. 05 (c) Rational design of enzyme inhibitors & principles of enzyme inhibitors. 05 Q.3 (a) What is hypertension? explain recent development in antihypertensive drug. 06 (b) What are the requirements for antihistaminic agents that target H1 & H2 05 receptors? (c) Write in brief about the recent development in Adrenergic & Cholinergic agents. 05 Q.4 (a) Write in detail about recently discovered antimetabolites as anticancer agents. 06 (b) Enlist the strategic plan to cure viral infection, classify antiviral agents based on 05 site of action (c) Add a note on COX-1 & COX-2 inhibitors. 05 Q.5 (a) Give a role of chirality in selective and specific therapeutic agents 06 (b) Add a note on carrier linked prodrugs. 05 (c) Rationale of prodrug design and practical consideration of prodrug design 05 Q. 6 (a) Give the strategies to combat drug resistance in antibiotics and anticancer therapy 06 (b) Give the various bioisosteric replacement strategies 05 (c) Give the Genetic principles of drug resistance 05 Q.7 (a) Enlist the stages of drug discovery and explain lead discovery 06 (b) Explain types of receptors and give theories of drug receptor interaction 05 (c) Add a note on identification, validation and diversity of drug targets 05 *************** Seat No.: _____ Enrolment No. _____________ GUJARAT TECHNOLOGICAL UNIVERSITY M. Pharm - SEMESTER III - EXAMINATION – WINTER -2017 Subject Code: 930101 Date: 10/11/2017 Subject Name: Advanced Medicinal Chemistry Time: 10:30 AM to 01:30 PM Total Marks: 80 Instructions: 1. Attempt any five questions. 2. Make suitable assumptions wherever necessary. 3. Figures to the right indicate full marks. Q.1 (a) What are different synthetic approaches used in combinatorial chemistry. 10 Discuss their applications. (b) Write note on various immunosuppressants 06 Q.2 (a) Discuss chemistry and SAR of angiotensin receptor blockers 08 (b) Discuss chemistry and SAR of glucocorticoids and recently developed 08 glucocorticoids Q.3 (a) Discuss SAR of tetracyclines and recently discovered tetracyclines 06 (b) Discuss about various HIV protease inhibitors 05 (c) Write detailed note on mineralocorticoids 05 Q.4 (a) How resistance is devloped in bacteria? What are the different methods of 08 treatment used to overcome it? Classify antibiotics. Outline synthyetic route of sparfloxacin. (b) Explain in detail rationale behind application of microorganisms for drug 08 synthesis with suitable examples. What are merits and demerits of this technique? Q.5 (a) Discuss about development and fate of COX-2 inhibitors. What are alternate 08 targets for NSAIDS? (b) Enlist different neurodegenerative diseases? Discuss on diseases you have 08 studied with recent advances in their therapy. Q. 6 (a) Which are the different methods used for synthesis of peptides? Discuss about 10 method developed by Bruce Merrifield. Why peptides are useful as drugs? What are their pitfalls? (c) Discuss enzyme immobilization techniques 06 Q.7 Give detailed account on recent advances in the therapy of following diseases with their merits and demerits. (a) Tuberculosis 06 (b) Allergy 05 (c) Diabetes (type I & II) 05 *************** Seat No.: ________ Enrolment No.______________ GUJARAT TECHNOLOGICAL UNIVERSITY M.PHARM – SEMESTER -1 - EXAMINATION –WINTER - 2018 Subject Code: MPC103T Date: 05/01/2019 Subject Name: Advanced Medicinal Chemistry Time :10:30 AM TO 01:30 PM Total Marks: 80 Instructions: 1. Attempt any five questions. 2. Make Suitable assumptions wherever necessary. 3. Figures to the right indicate full marks. Q.1 (a) Enumerate stages of drug discovery and explain methods of lead discovery. 06 (b) Explain the theories involved in drug receptor interaction. 05 (c) Why we required lead optimization? Explain methods involved in lead 05 optimization. Q.2 (a) Add a note on rational behind prodrug design. 06 (b) Explain strategies to combat drug resistance in antibiotics therapy. 05 (c) Why is cancer so difficult to cure? Explain with drug resistance. 05 Q.3 (a) Why analog design important in drug design? Explain any one strategy 06 involved in analog design. (b) Write recent advancement in anticancer agents. 05 (c) Why stereochemistry is important in drug action? 05 Q.4 (a) Explain the strategies involved in development antiviral agents. 06 (b) Explain enzyme kinetics & principles of enzyme inhibitors. 05 (c) Add a note on enzyme inhibitors in basic research. 05 Q.5 (a) Explain design of peptidomimetics. 06 (b) Explain chemistry of prostaglandins, leukotrienes and thromboxanes. 05 (c) Add a note on identification, validation and diversity of drug targets. 05 Q. 6 (a) Explain latest development of antihypertensive medication. 06 (b) Add a note on carrier linked prodrugs. 05 (c) Explain simplification approach in lead optimization 05 Q.7 (a) Explain non-covalently and covalently binding enzyme inhibitors. 06 (b) Add a note on COX-1 & COX-2 inhibitors. 05 (c) Explain H1 & H2 receptor antagonists. 05 ***************