Hemostasis, Coagulation and Fibrinolysis

· Module 1: Hemostasis, Coagulation, And Fibrinolysis ① Refers to the response to vascular injury...

· Module 1: Hemostasis, Coagulation, And Fibrinolysis ① Refers to the response to vascular injury that produces a platelet plug at the site of damage. Activated by small injuries to blood - vessels - SMALL INJURY Rapid, short-lived response Components: -PLATELET PLUG ▪ Vascular system ① ② Arteries Veins Capillaries ▪ Platelets Secondary hemostasis -- Hemostasis The process that keeps blood fluid in the circulation and then, when an injury occurs, produces a clot to stop the bleeding, keeps the clot confined to the ② site of injury and finally dissolved the Activated by large injury to the blood - clot as the wound heals. vessels Delayed, long-term response Key components of hemostasis Involves the enzymatic activation of the LARGE - Cellular coagulation proteins to produce fibrin INJURY ▪ Cells of vascular intima from fibrinogen. - FIBRIN ▪ Extravascular tissue factor Stabilization of the platelet plug formed bearing cells in primary hemostasis. ▪ Platelets Components: Plasma components ▪ Coagulation factors ▪ Coagulation proteins ▪ Inhibitors ▪ Fibrinolytic proteins ▪ Inhibitors Fibrinolysis The stable clot is dissolved – ③ Primary hemostasis proteolytic digestion of - fibrinogen and fibrin by the enzyme plasmin. The final event of hemostasis