Virus Replication Lecture Notes (PDF)

Faculty of Veterinary Medicine UVMED Lecture : Virus Replication 1,2 Dr : Ayman El-Deeb Date :22 and 29/10/2024 Definition Viral Replication: All steps and process happen during multiplication of the virus in the live cell. It is the most important Virus- cell Inte...

Faculty of Veterinary Medicine UVMED Lecture : Virus Replication 1,2 Dr : Ayman El-Deeb Date :22 and 29/10/2024 Definition Viral Replication: All steps and process happen during multiplication of the virus in the live cell. It is the most important Virus- cell Interaction from medicine point of view. The virus multiplication cycle include many steps as following: Steps of virus replication: Virus attachment to host cells. Virus entry into cells (Penetration). Virus Uncoating. Genome replication strategies. Transcription. Translation. Assembly Maturation Exit and of progeny virions. ATTACHMENT Click after each step to view process PENETRATION HOST UNCOATING FUNCTIONS Transcription Translation REPLICATION VIRAL LIFE ASSEMBLY CYCLE (MATURATION) RELEASE 1 MULTIPLICATION One Step growth curve. One Step growth curve. One Step growth curve. Virus attachment to host cells Attachment Attachment means that virus attachment protein will bind cell receptor: Cellular receptor rus entry into cells (Penetrati Penetration Penetration Penetration Penetration Penetration Virus Uncoating. Virus Uncoating. Genome replication strategies Virus Genome. Viral genome replication strategies Protein Translation Protein Assembly - All of the components of the virus assembled into a particle. - Occurs when an appropriate concentration of virus proteins and genomic nucleic acids are reached and localized at specific sites within the infected cell. - Some particles self-assemble. Maturation Stage in the life cycle of the virus when it becomes infectious. Viral or cellular proteases often involved. One or more of the capsid or envelope proteins may undergo a specific proteolytic cleavage, e.g. HIV Exit and of progeny virions Budding Exit and of progeny virions Budding Exit and of progeny virions Exocytosis Exit and of progeny virions Cell lysis Exit and of progeny virions Example of virus replication Picornavirus Example of virus replication Picornavirus Example of virus replication Coronavirus Example of virus replication Retrovirus Example of virus replication Retrovirus Example of virus replication Influenzavirus Example of virus replication Poxvirus Example of virus replication Poxvirus