RCSI Medicines 1: Druglikeness and BCS (PDF)
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RCSI School of Pharmacy
RCSI
Dr Sam Maher
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Summary
This document is a presentation on Druglikeness and the Biopharmaceutics Classification System (BCS). It contains learning outcomes, definitions, and examples related to the topic. The document includes topics such as the Rule of 5, the Biopharmaceutics Classification System (BCS) and the interactions between solubility and permeability.
Full Transcript
RCSI Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn Druglikeness and the BCS (I, II) Course: Masters in Pharmacy (MPharm), BSc Advanced Therapeutic Technologies Module: Medicines 1 Lecturer: Dr Sam Maher LEARNING OUTCOMES 1. Describe the physicochemical prope...
RCSI Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn Druglikeness and the BCS (I, II) Course: Masters in Pharmacy (MPharm), BSc Advanced Therapeutic Technologies Module: Medicines 1 Lecturer: Dr Sam Maher LEARNING OUTCOMES 1. Describe the physicochemical properties of a drug that important in solubility and permeability 2. Define the Rule of 5 and apply it to conventional small molecules 3. Define the BCS and the 4 drug categories 4. Predict BCS solubility and permeability 5. Outline the uses of BCS in pharmaceutical science DRUGS ARE REQUIRE TO HAVE A DELICATE BALANCE BETWEEN HYDROPHILICITY & LIPOHILICITY TO DATE, WE HAVE EMPHASISED THE KEY REQUIREMENT THAT A DRUG MUST GO IN TO SOLUTION IN ORDER TO BE ABSORBED AND ACT ON ITS BIOLOGICAL TARGET (e.g. RECEPTOR OR ENZYME). WHILE WE EVALUATED SEVERAL STRATEGIES TO IMPROVE SOLUBILITY TO ENSURE SOLUBILISATION, THERE IS A REQUIREMENT FOR A CARFUL BALANCE BETWEEN HYDROPHILICITY AND LIPOPHILICITY. HYDROPHILICITY LIPOPHILICITY DRUGLIKENESS: LIPINSKI’S RULE OF FIVE HYDROGEN BOND DONORS
