Medication Practice Questions PDF

**Bipolar Disorder Treatment Questions** 1. **Which of the following is the most effective first-line treatment for bipolar depression?** - A\) Lamotrigine - B\) Fluoxetine - C\) Lithium - D\) Valproate **Answer: A) Lamotrigine** *(Lamotrigine is effective for **bi...

**Bipolar Disorder Treatment Questions** 1. **Which of the following is the most effective first-line treatment for bipolar depression?** - A\) Lamotrigine - B\) Fluoxetine - C\) Lithium - D\) Valproate **Answer: A) Lamotrigine** *(Lamotrigine is effective for **bipolar depression**, while lithium and valproate are better for **mania**.)* 2. **A 32-year-old patient with Bipolar I disorder presents with acute mania, agitation, and aggressive behavior. Which medication should be used for immediate stabilization?** - A\) Lamotrigine - B\) Olanzapine - C\) Fluoxetine - D\) Bupropion **Answer: B) Olanzapine** *(Atypical antipsychotics like olanzapine are **first-line for acute mania stabilization**.)* 3. **Which of the following medications is most likely to induce a manic episode in a patient with bipolar disorder?** - A\) Sertraline - B\) Quetiapine - C\) Lithium - D\) Valproate **Answer: A) Sertraline** *(SSRIs, when used **without a mood stabilizer**, can **trigger mania**.)* 4. **Which treatment is most appropriate for rapid-cycling bipolar disorder?** - A\) Lithium - B\) Valproate - C\) Lamotrigine - D\) Quetiapine **Answer: B) Valproate** *(**Rapid cycling** is more responsive to **valproate** than lithium.)* 5. **Which of the following lab tests must be monitored regularly in patients taking lithium?** - A\) AST/ALT - B\) TSH - C\) CBC - D\) Vitamin D levels **Answer: B) TSH** *(Lithium can cause **hypothyroidism**, requiring regular TSH monitoring.)* **Major Depressive Disorder (MDD) Treatment Questions** 6. **Which of the following antidepressants is most associated with weight gain and sedation?** - A\) Sertraline - B\) Fluoxetine - C\) Mirtazapine - D\) Bupropion **Answer: C) Mirtazapine** *(Mirtazapine **increases appetite and sedation**---useful for underweight or insomniac patients.)* 7. **Which antidepressant is contraindicated in patients with seizure disorders?** - A\) Escitalopram - B\) Bupropion - C\) Sertraline - D\) Venlafaxine **Answer: B) Bupropion** *(Bupropion **lowers seizure threshold**, making it **contraindicated in epilepsy**.)* 8. **Which of the following medications is FDA-approved for treatment-resistant depression?** - A\) Ketamine - B\) Sertraline - C\) Venlafaxine - D\) Lithium **Answer: A) Ketamine** *(Ketamine is used for **treatment-resistant depression**, especially via **intranasal esketamine**.)* 9. **Which antidepressant is preferred in patients with both depression and neuropathic pain?** - A\) Paroxetine - B\) Duloxetine - C\) Trazodone - D\) Sertraline **Answer: B) Duloxetine** *(Duloxetine is a **dual SNRI** that treats both **MDD and neuropathic pain**.)* 10. **A patient with MDD fails multiple SSRI trials. Which next-line medication class is most appropriate?** - A\) MAOIs - B\) TCAs - C\) SNRIs - D\) Antipsychotics **Answer: C) SNRIs** *(SNRIs like venlafaxine are **preferred after SSRI failure** before TCAs or MAOIs.)* **PTSD Treatment Questions** 11. **Which of the following is FDA-approved for PTSD treatment?** - A\) Sertraline - B\) Fluoxetine - C\) Mirtazapine - D\) Trazodone **Answer: A) Sertraline** *(Only **sertraline and paroxetine** are FDA-approved for PTSD.)* 12. **Which medication is most effective for PTSD-related nightmares?** - A\) Trazodone - B\) Prazosin - C\) Clonazepam - D\) Olanzapine **Answer: B) Prazosin** *(Prazosin **blocks norepinephrine**, reducing PTSD nightmares.)* 13. **Which class of medications should generally be avoided in PTSD due to potential worsening of symptoms?** - A\) SSRIs - B\) Benzodiazepines - C\) Beta-blockers - D\) SNRIs **Answer: B) Benzodiazepines** *(Benzodiazepines can **worsen dissociation and fear extinction**.)* 14. **Which therapy is the gold-standard treatment for PTSD?** - A\) Dialectical Behavior Therapy - B\) Cognitive Processing Therapy - C\) Eye Movement Desensitization and Reprocessing (EMDR) - D\) Exposure Therapy **Answer: D) Exposure Therapy** *(**Prolonged Exposure Therapy** is the most **evidence-based PTSD treatment**.)* 15. **Which PTSD treatment works by targeting trauma-related automatic negative thoughts?** - A\) EMDR - B\) Cognitive Processing Therapy (CPT) - C\) Biofeedback - D\) Hypnotherapy **Answer: B) Cognitive Processing Therapy (CPT)** *(CPT **modifies trauma-related negative beliefs**.)* **Comparative Treatment Traps** 16. **Which medication is effective for both PTSD and major depression?** - A\) Paroxetine - B\) Prazosin - C\) Lithium - D\) Valproate **Answer: A) Paroxetine** *(Paroxetine is **FDA-approved for both PTSD and depression**.)* 17. **Which treatment is preferred for bipolar depression over MDD?** - A\) SSRIs - B\) Lithium - C\) Bupropion - D\) MAOIs **Answer: B) Lithium** *(Lithium is a **gold-standard mood stabilizer**, unlike SSRIs.)* 18. **Which medication should be avoided in both PTSD and bipolar disorder due to worsening symptoms?** - A\) Sertraline - B\) Lamotrigine - C\) Clonazepam - D\) Trazodone **Answer: C) Clonazepam** *(Benzodiazepines worsen **PTSD avoidance** and trigger **mania in bipolar patients**.)* 19. **Which antidepressant has the lowest risk of sexual dysfunction?** - A\) Bupropion - B\) Sertraline - C\) Paroxetine - D\) Escitalopram **Answer: A) Bupropion** *(Bupropion is an **NDRI** with minimal sexual side effects.)* 20. **Which therapy is most beneficial for PTSD patients with comorbid Borderline Personality Disorder?** - A\) Exposure Therapy - B\) Dialectical Behavior Therapy (DBT) - C\) EMDR - D\) Psychodynamic Therapy **Answer: B) Dialectical Behavior Therapy (DBT)** *(DBT is best for PTSD patients with **emotional dysregulation**.)* **Bipolar Disorder: Advanced Treatment Questions** 1. **Which of the following mood stabilizers is most effective in preventing future manic episodes?** - A\) Lamotrigine - B\) Lithium - C\) Carbamazepine - D\) Valproate **Answer: B) Lithium** *(Lithium is the **gold-standard** for preventing mania and reducing suicide risk in bipolar disorder.)* 2. **Which of the following medications is most appropriate for maintenance treatment in a patient with Bipolar I disorder who experiences depressive episodes but is at high risk for mania?** - A\) Lamotrigine - B\) Fluoxetine - C\) Lithium - D\) Bupropion **Answer: C) Lithium** *(While **lamotrigine** is good for bipolar depression, **lithium** provides mood stabilization with **mania prevention**.)* 3. **Which medication has been shown to reduce suicide risk in patients with bipolar disorder?** - A\) Quetiapine - B\) Valproate - C\) Lithium - D\) Olanzapine **Answer: C) Lithium** *(Lithium is the **only mood stabilizer with proven anti-suicidal effects**.)* 4. **A 27-year-old male with Bipolar I disorder presents with acute mania. Which medication should be avoided due to its slow onset of action?** - A\) Olanzapine - B\) Lithium - C\) Haloperidol - D\) Valproate **Answer: B) Lithium** *(Lithium takes **5--7 days** for full effect; **antipsychotics** work faster in acute mania.)* 5. **Which mood stabilizer has the highest risk of Stevens-Johnson syndrome, requiring slow dose titration?** - A\) Valproate - B\) Carbamazepine - C\) Lamotrigine - D\) Lithium **Answer: C) Lamotrigine** *(Lamotrigine requires **slow titration** to prevent **Stevens-Johnson syndrome**.)* 6. **Which of the following drugs is an antipsychotic approved for both bipolar depression and schizophrenia?** - A\) Quetiapine - B\) Lithium - C\) Valproate - D\) Lamotrigine **Answer: A) Quetiapine** *(**Quetiapine** treats **bipolar depression, schizophrenia, and acute mania**.)* **Major Depressive Disorder: Advanced Treatment Questions** 7. **Which antidepressant is most likely to cause dose-dependent hypertension?** - A\) Sertraline - B\) Bupropion - C\) Venlafaxine - D\) Mirtazapine **Answer: C) Venlafaxine** *(Venlafaxine (SNRI) causes **hypertension at higher doses**.)* 8. **Which medication is considered the best option for treatment-resistant major depressive disorder?** - A\) Trazodone - B\) Ketamine - C\) Buspirone - D\) Aripiprazole **Answer: B) Ketamine** *(**Intranasal esketamine** is approved for **treatment-resistant depression**.)* 9. **Which antidepressant is best suited for a patient with MDD who has significant weight loss and insomnia?** - A\) Sertraline - B\) Fluoxetine - C\) Mirtazapine - D\) Bupropion **Answer: C) Mirtazapine** *(Mirtazapine causes **increased appetite and sedation**.)* 10. **Which medication should be avoided in a patient with major depressive disorder and an active alcohol use disorder?** - A\) Sertraline - B\) Trazodone - C\) Bupropion - D\) Mirtazapine **Answer: C) Bupropion** *(Bupropion **lowers seizure threshold**, increasing risk in alcohol withdrawal.)* **PTSD: Advanced Treatment Questions** 11. **Which PTSD symptom is most directly targeted by prazosin?** - A\) Flashbacks - B\) Dissociation - C\) Nightmares - D\) Hypervigilance **Answer: C) Nightmares** *(Prazosin blocks **norepinephrine receptors**, reducing nightmares.)* 12. **Which therapy is considered first-line for PTSD treatment?** - A\) Dialectical Behavior Therapy - B\) Cognitive Processing Therapy - C\) Eye Movement Desensitization and Reprocessing - D\) Interpersonal Therapy **Answer: B) Cognitive Processing Therapy** *(CPT is a **first-line therapy** that targets **trauma-related negative beliefs**.)* 13. **Which of the following PTSD treatments should be avoided due to potential symptom worsening?** - A\) SSRIs - B\) Benzodiazepines - C\) Propranolol - D\) Prazosin **Answer: B) Benzodiazepines** *(Benzos impair **fear extinction** and increase **dissociation**.)* 14. **Which PTSD treatment works by reprocessing trauma through guided eye movements?** - A\) EMDR - B\) Cognitive Behavioral Therapy - C\) Exposure Therapy - D\) Acceptance and Commitment Therapy **Answer: A) EMDR** *(Eye Movement Desensitization and Reprocessing (EMDR) involves **bilateral eye stimulation** to process trauma.)* 15. **Which of the following should be prioritized in PTSD patients at high risk for suicide?** - A\) Short-term hospitalization - B\) Increasing social support - C\) Prescribing benzodiazepines for symptom relief - D\) Initiating long-term therapy **Answer: A) Short-term hospitalization** *(Acute suicide risk requires **immediate hospitalization**.)* **Comparative Treatment Questions** 16. **Which of the following is the best choice for PTSD with co-occurring major depression?** - A\) Prazosin - B\) Paroxetine - C\) Lithium - D\) Haloperidol **Answer: B) Paroxetine** *(Paroxetine is **FDA-approved for both PTSD and depression**.)* 17. **Which treatment is preferred for depression in bipolar disorder, but not for unipolar depression?** - A\) SSRIs - B\) Lithium - C\) Bupropion - D\) MAOIs **Answer: B) Lithium** *(Lithium is **used in bipolar depression**, but SSRIs are preferred for unipolar depression.)* 18. **Which treatment should be avoided in both PTSD and bipolar disorder due to potential symptom worsening?** - A\) Sertraline - B\) Lamotrigine - C\) Clonazepam - D\) Trazodone **Answer: C) Clonazepam** *(Benzos worsen **PTSD avoidance** and **trigger mania** in bipolar disorder.)*