Macrocytic Anaemia (2) Pernicious Anaemia (3) PDF
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Uploaded by VersatileWisdom5978
UMST
Dr. Sahar Gamal Elbager
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Summary
These slides provide an overview of macrocytic anaemia, focusing on pernicious anaemia and its non-megaloblastic counterparts. The presentation delves into the pathogenesis, diagnostic approaches (like the Schilling test), and a range of potential underlying causes, including alcohol use and various medical conditions. This lecture material is aimed at a professional audience.
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Macrocytic anaemia (2) Pernicious anaemia & Non Megaloblastic anaemia Presented by Dr. Sahar Gamal Elbager Assistant Professor of Haematology UMST Pernicious anaemia 02/08/25 Dr.Sahar Gamal Elbager 2 ...
Macrocytic anaemia (2) Pernicious anaemia & Non Megaloblastic anaemia Presented by Dr. Sahar Gamal Elbager Assistant Professor of Haematology UMST Pernicious anaemia 02/08/25 Dr.Sahar Gamal Elbager 2 Pathogenesis of pernicious anaemia 02/08/25 Dr.Sahar Gamal Elbager 3 Laboratory diagnosis of pernicious anaemia 02/08/25 Dr.Sahar Gamal Elbager 4 Schilling Test 02/08/25 Dr.Sahar Elbager Other macrocytic anaemias There are many non - megaloblastic causes of macrocytic anaemia. The exact mechanisms creating large red cells in each of these conditions is not clear although increased lipid deposition on the red cell membrane or alterations of erythroblast maturation time in the marrow may be implicated. 02/08/25 Dr.Sahar Gamal Elbager 6 Causes of macrocytosis Alcohol Liver disease Myxoedema Myelodysplastic syndromes Cytotoxic drugs Aplastic anaemia Pregnancy Smoking Reticulocytosis Myeloma and paraproteinaemia Neonatal 02/08/25 Dr.Sahar Gamal Elbager 7 Thank you 02/08/25 Dr.Sahar Gamal Elbager 8
