Lung Cancer PDF
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Uploaded by WorthwhileHippopotamus
University of Birmingham
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Summary
This document provides information on lung cancer, including different types, associated factors (smoking, location), and various diagnostic markers. It details the morphology, histology, molecular characteristics, and treatment options for different types of lung cancer. The information presented is detailed and comprehensive.
Full Transcript
Lung Cancer Small cell – 15% Non-small cell – 85% Very aggressive Associated w/smoking. Usually central, 5% peripheral Metastatic/ on brain Adenocarcinoma Squamous cell...
Lung Cancer Small cell – 15% Non-small cell – 85% Very aggressive Associated w/smoking. Usually central, 5% peripheral Metastatic/ on brain Adenocarcinoma Squamous cell (common) carcinoma Precursor/ unknown. Combine with NSCLC **most common 60%. Related to smoker. CK7 +/- Less common – 20% A raise from glandular cell TTF-1 +/- Usually central, sometimes peripheral. Exact precursor cells CD56 + located and a raise from lobar bronchus. (unknown) CK AE1/AE3 + dot like Vast majority, smoking related. IHC Often peripheral Synaptophysin + Histology: Chromogranin A + Ki67: very high 65-100% CK5/6 + P63 + No target. Mucinous Non- Mucinous IHC P40 + CK AE1/AE3 + Ki67 – variable CK7 + TTF-1 + Napsin A + CK AE1/AE3 + IHC PDL-1 Ki67 - variable eGFR, ALK, PDL-1, ROS-1, KRAS, BRAF, NTRAK, MET, Molecular Molecular RET, Her2 Neuroendocrine tumours including small cell ** Neuroendocrine neoplasms (>5 mm size) large cell neuroendocrine carcinoma ** not combined with NSCLC High grade w/NSL morphology. Not associated w/smoking. >10 mitosis. Common in young adult. 90% smoking related. 90% of carcinoids are resectable. More in men, >65 yrs Different genetics to high grade NE Variable genetic profile. Peripheral or central. Typical Atypical Carcinoid Morphology Carcinoid Mitotic rate 1% of PDL1 positive: second line. Diagnosis: FISH (translocation) TREATMENT: Crizotinib.
