Inflammation Lecture Slides PDF

INFLAMMATION NURS 7053 Learning Outcomes By the end of this module, students should be able to: 1.Summarize the purpose and physiological significance of inflammation in the immune response. 2.Examine the key characteristics and components of the inflammatory process. 3.Compare and contrast the r...

INFLAMMATION NURS 7053 Learning Outcomes By the end of this module, students should be able to: 1.Summarize the purpose and physiological significance of inflammation in the immune response. 2.Examine the key characteristics and components of the inflammatory process. 3.Compare and contrast the roles of various cells, mediators, and plasma protein systems involved in the inflammatory response. 4.Arrange in sequence the events involved in activating and regulating the inflammatory response. 5.Predict clinical manifestations of inflammation based on knowledge of its underlying mechanisms. Inflammation Case Discussion 1. Which cells will respond to this inflammatory condition? 2. What is the general order in which they will respond? 3. What is the role of each cellular player? 4. Explain the underlying pathophysiology for each of these symptoms: (a) Pain, (b) warmth, (c) redness, (d) edema 5. Briefly identify the function of each of the plasma protein systems Overview Purpose of Inflammation Destroy infectious and injurious organisms Wall off the site of infection Stimulate and enhance the immune response Stimulate tissue healing Inflammation Characteristics Occurs in vascular tissues Immediate Nonspecific No memory Will affect anything in the vicinity Self limiting Inflammation Components Cells Inflammation Components Inflammatory chemicals Inflammation Components Plasma protein systems Inflammation Activation Inflammation Overview Inflammation Overview WBCs Inflammation Overview Inflammation Think, Pair, Share Take a minute to reflect on the inflammatory response in general. Consider the following prompts: What is the purpose of inflammation? What are the characteristics of inflammation? What components are involved in the inflammatory response? Turn to a neighbor, and take turns describing your understanding of each prompt Cells of inflammation and inflammatory mediators Mast Cell Location & Activation Inflammation Mast Cell Function – immediate release of histamine Inflammation Mast Cell Functions of Histamine Vasodilation Increased capillary permeability Non-vascular smooth muscle contraction Inflammation Mast Cell Histamine receptors H1 receptors Arterial smooth muscle – vasodilation Endothelial cells – endothelial cell retraction/increased capillary permeability Bronchial smooth muscle – bronconstriction WBCs – chemotaxis Mast cells – more degranulation Inflammation Mast Cell Histamine receptors H2 receptors Mast cells – inhibits degranulation WBCs – inhibits chemotaxis Parietal and chief cells– HCl and gastric enzyme secretion Inflammation Mast Cell Function – Synthesis of Mediators (AA metabolites) Prostaglandins (PgE2) Leukotrienes Inflammation Mast Cell Summary Inflammation Basophils Inflammation Neutrophils Inflammation Neutrophils Phagocytosis Inflammation Eosinophils Inflammation Monocytes/Macrophages Inflammation Monocytes/Macrophages Inflammation Platelets Inflammation Endothelial Cells Inflammation One Minute Paper Take a minute to solidify your understanding about the cells that are involved in the inflammatory response. List the seven cells that we have discussed and note their unique characteristics Plasma Protein Systems Complement System Inflammation Plasma Protein Systems Complement System Opsonization with complement proteins Inflammation Plasma Protein Systems Clotting System Inflammation Plasma Protein Systems Kinin System Inflammation Plasma Protein Systems Summary/Interactions Inflammation Jigsaw Activity Divide into groups of 3-4 Each group will be assigned one of the plasma protein systems. You will have five minutes to identify the key characteristics of your assigned plasma protein system and then each group will report back to the class Jigsaw Activity Divide into groups of 3-4 Each group will be assigned one of the plasma protein systems. You will have five minutes to identify the key characteristics of your assigned plasma protein system and then each group will report back to the class Local Manifestations Inflammation Local Manifestations Heat & Redness Wound infection Pain Swelling Loss of function Deep vein thrombosus http://www.coloplast.com/WoundAndSkinCare/Topics Inflammation Systemic Manifestations Fever Leukocytosis Increased circulating plasma proteins Increased ESR Low albumin Inflammation 3-2-1 Reflection Write down the following: 3 key concepts you learned about inflammation 2 ways this knowledge will impact your future practice 1 question you still have about this topic