Lecture Notes Membranes PDF
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These lecture notes cover various aspects of pain, inherited pain disorders, and drug mechanisms like local anesthetics. They explore the specifics of sensory neuron activity and the differences in mechanism between different drug types.
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Module 4 : Nan and Pain 02/10/24 E S O G G O I Genetically - Validatea -...
Module 4 : Nan and Pain 02/10/24 E S O G G O I Genetically - Validatea - pain disorders Navl 7. and Pain · fast activation/inactivation ↑ expression in PNS · current at -60--YomV Inherited Erythromelalgia mutation causes : O · I-v hyperpolarisation ↳ easier openi · lowed deactivation ↑ current · - hyperexcitability symptoms : · episodic intense burning pain · redness I warmth Narl 8 and Pain. -sensory neurone - specific · contributes majority of current in Ap upstroke · promotes sustained repetitive finingy · PGE2 inflammatory mediators, other Kinases > Carl 8 activity + threshold -. · present free nociceptive nerve endings, : : initiate nociceptive excitability promote pain signalling Recovers rapidly from Ap :. high freg aps lower threshold & O ( higher current summary 1st gen-non-selective Jar blockers Local anaesthetics Phenytoin Lidocaine · , · Loss of sensation ↓ X ideal for LT use · use dependent block · Bind to 1 , 111 & IV S6 (inactivation) "lock in inactiv Biologics vs small molecule · Binding specificity Ab/peptides metabolised as part of normal protein · dynamics · AvoidGrug : drug interactions · Poor membrane permeability · Poor CNS penetrance · Adverse immune reaction ↑ success rate (13 2.%). of Biologics us small molecule (7 6.). - FDA approval phase ! increased L 112 like human trials not began yet O-2023 !
