Lecture 9 10.pptx PDF
Document Details
Carole Parent
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Summary
This lecture continues on the concept of cell signaling, explaining the roles of Cyclic-AMP (cAMP), PLC/PKC, calcium and GPCRs. It also covers how signaling waves propagate, and how smell and vision rely on GPCRs. The lecture is part of a larger course, and the lecturer mentions that the final exam will cover today's material, along with the previous material. The next section will be on plant cell culture.
Full Transcript
Cell Signaling (continued) Cyclic-AMP (cAMP) activation through GPCRs PLC/PKC signaling PLC/PKC signaling Calcium/Calmodulin controls downstream kinase activity Calcium transients trigger many cellular processes Many signals trigger Ca2+ release (not just GPCRs) Skeletal mu...
Cell Signaling (continued) Cyclic-AMP (cAMP) activation through GPCRs PLC/PKC signaling PLC/PKC signaling Calcium/Calmodulin controls downstream kinase activity Calcium transients trigger many cellular processes Many signals trigger Ca2+ release (not just GPCRs) Skeletal muscle contracts in response to calcium release Ca2+ triggers regulated secretion (i.e. in neurons) Sperm entry triggers a calcium wave during fertilization Ca2+ entry via plasma membrane Ca2+ channels and/or its release from the endoplasmic reticulum increases cytosolic Ca2+ PLC initiates calcium waves in egg activation Calcium waves propagate through feedback IP3 receptors require both IP3 and Ca2+ How do signaling waves propagate across many cells? Carole Parent How do signaling waves propagate across many cells? Hashimura et al. Com. Biol., 2019 Hiratsuka et al., eLIFE, 2015 Smell and Vision Depend on GPCRs That Regulate Ion Channels Signals are amplified by cascades Rod photoreceptor Rhodopsins – Light sensitive GPCRs There is cross-talk between many signaling pathways and types of receptors JAK-STAT signaling Lab and closing remarks Next section on plant cell culture – Dr. Peng Wang Final exam will include today’s material in addition to the previous material. Hope you enjoyed this section of the course and learned something – Please take evaluations seriously Good Luck with the quiz!
