Lecture 3 - Histology of Blood Cells II PDF
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Uploaded by HardyDystopia
Helwan National University
Safinaz Salah Eldin
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Summary
This lecture covers the histology of blood cells, including monocytes, lymphocytes, platelets, and bone marrow. It details the characteristics, functions, and clinical implications of each cell type.
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Faculty of Medicine Academic Year: 2024-2025 Year: 1 Semester: 1 Module: BLOOD and body fluids (blf) 103 Histology of Blood cells II By: Safinaz Salah Eldin Professor of histology, faculty of medicine ,Cairo university Department: Histology 12/29/2024...
Faculty of Medicine Academic Year: 2024-2025 Year: 1 Semester: 1 Module: BLOOD and body fluids (blf) 103 Histology of Blood cells II By: Safinaz Salah Eldin Professor of histology, faculty of medicine ,Cairo university Department: Histology 12/29/2024 22 Objectives 1. Recognize different blood elements. 2. Describe the histological characteristics of RBCs, leucocytes (granular, non-granular) & platelets at L.M. and E.M. levels 3. Correlate normal RBCs structural adaptation for proper function. 4. Relate RBCs structural abnormalities to some clinical conditions (e.g. hemolytic anemia) 5. Differentiate between RBCs and WBCs. 6. Recall normal RBCs, leucocytic and platelet count. 7. Correlate the ultrastructure components of platelets to their function. 8. Discriminate different types of WBCs from each other in various blood films. 12/29/2024 BLF - 103 33 Objectives 9. Point out abnormal variations in count and shape of RBCs. 10.Identify deviation in WBCs and platelet counts and some of their causes. 11.Interpret alterations in RBCs, WBCs and platelet count and relate them to the possible clinical conditions. 12.Define the total & differential leucocytic count. 13.Describe the histological organization & sites of the bone marrow. 14.Identify types of bone marrow. 15.Recognize the histological structure of the cells involved in various stages of hemopoiesis. 12/29/2024 BLF - 103 44 Introduction Non granular leucocytes Comparisn between RBCs & WBCs Platelets Bone marrow Haemopeosis 12/29/2024 BLF - 103 55 Non granular leucocytes Non granular leucocytes Lymphocytes Monocytes Small Large 12/29/2024 BLF - 103 6 Monocytes Percentage : 3-8 % , 13 - 20 µm diameter Life span: 3 days in blood & 3 months in C T L.M.: Nucleus: Large, eccentric, kidney-shaped, pale with 1 or 2 nucleoli. Cytoplasm: non- clear pale basophilic, frosted glass appearance due to lysosomes (azurophil granules). 12/29/2024 BLF - 103 7 Cont monocytes E.M. Nucleus: Euchromatic with clear nucleolus Cytoplasm: Have pseudopodia, mitochondria, rER, well developed G.A. & many lysosomes 1ry & 2ry 12/29/2024 BLF - 103 8 Cont monocytes function Highly phagocytic cells: 1.Remain in the blood for 3 days. 2.Then enter C.T. & change into macrophages. 3.Antigen presenting cells. 4.Precursors of all phagocytic cells: e.g dust cells , kupffer cells, osteoclasts & microglia. 12/29/2024 BLF - 103 9 Cont monocytes Monocytosis: Increased percentage of monocytes > 8% due to: chronic infections: T.B., syphilis & glandular fever and monocytic leukemia. Monocytopenia: decrease percentage of monocytes 30%, due to: physiological in children. Chronic infections e.g T.B & whooping cough - Leukemia. Lymphocytopenia:⇊ percentage of lymphocytes
