Pharmaceutical Organic Chemistry 1 (Introduction) Lecture Notes PDF

Pharmaceutical Organic Chemistry 1 (Inroduction) By Dr. Aya Almatary HELLO! I am Aya Almatary Lecturer of Pharmaceutical Organic Chemistry 2  Team Presentation Prof. Magda Abdelaziz Dr Abdelrahman...

Pharmaceutical Organic Chemistry 1 (Inroduction) By Dr. Aya Almatary HELLO! I am Aya Almatary Lecturer of Pharmaceutical Organic Chemistry 2  Team Presentation Prof. Magda Abdelaziz Dr Abdelrahman Dr Mohamed Zidan Prof. of Pharmaceutical Organic Chemistry Vice dean of the Faculty Hamdy Lecturer. of Pharmaceutical Organic Chemistry Lecturer. of Pharmaceutical Organic Chemistry 3  ‫‪SWOT‬‬ ‫‪Analysis‬‬ ‫ التطوير المستمر للتعليم والتعلم بتطبيق طرق‬ ‫تحقيق التميز في مجال الصيدلة من‬ ‫التعليم الحديثة والتعلم الذاتي‪.‬‬ ‫تأهيل الخريجين لتطبيق الممارسة الصيدلية‬ ‫ ‬ ‫خالل التعليم المبتكر‪ ،‬والممارسة‬ ‫الجيدة ضمن فريق الرعاية الصحية والعمل في‬ ‫المعاصرة‪ ،‬والمساهمات العلمية‬ ‫المؤسسات الصيدلية المختلفة‪.‬‬ ‫اإلهتمام بالبحث العلمي والدراسات العليا‪.‬‬ ‫ ‬ ‫القيمة‬ ‫نشر ثقافة الجودة وتطوير اإلداء األكاديمي‬ ‫ ‬ ‫واإلداري‪.‬‬ ‫األهداف‬ ‫رؤية‬ ‫عظيم اإلفادة واالستفادة من المشاركة المجتمعية‪.‬‬ ‫ ‬ ‫الحصول على اإلعتماد اإلكاديمي والمؤسسي‬ ‫ ‬ ‫اإلستراتيجية‬ ‫الكلية‬ ‫القيم‬ ‫توفر كلية الصيدلة جامعة حورس ‪-‬‬ ‫النزاهة واألمانة‬ ‫ ‬ ‫رسالة‬ ‫ممارسة صيدلية ورعاية صحية عالية‬ ‫المساءلة والشفافية‬ ‫ ‬ ‫المحورية‬ ‫الكلية‬ ‫الجودة للمجتمع‪ ،‬وتحقيق مساهمات‬ ‫التعاون والتواصل‬ ‫ ‬ ‫ذات مغزى للبحث العلمى‪.‬‬ ‫التطوير المستمر‬ ‫ ‬ ‫جودة األداء‬ ‫ ‬ ‫‪4‬‬  Outline of this lecture ✘ Intro: Why do you study this subject ✘ The content of Ph. Org. Chem. 1 Course ✘ Grades distribution ✘ Atomic Structure ✘ Electron Configurations ✘ Chemical Bonding 5  Why do you study this subject? Vitamin B12 DNA Adrenaline  Timeline Prof. Magda Dr Abdelrahman Dr Abdelrahman Abdelaziz Introduction Alkane Alkene Alkyne Steriochemistry Alkyl Halides Alcohol & Ethers Dr Aya Dr Mohamed Dr Mohamed Dr Mohamed Zidan Zidan Zidan By the end of this course, you should be able to Perform Simple chemical reaction of aliphatic compounds and determine the stereochemistry of different molecules 7  Grades distribution Student work (SW) Practical (P/T) W Activity quiz Midterm OSPE Book Exam Final 5 5 5 5 5 15 50 8 Atomic Structure 9  Properties of subatomic particles Relative Relative Actual Mass Particle Symbol Charge Mass (g) 9.11x10-28 electron e - -1 negative 0 Is very small proton p + +1 positive 1 1.67x10-24 0 neutron n 0 neutral 1 1.67x10-24 10  Important Definitions ✘ The atomic number (Z): is the number of protons in the atom's nucleus. or the number of electrons around the nucleus. ✘ The mass number (A): is the number of protons plus neutrons. (All the atoms of a given element have the same atomic number). ✘ Isotopes: are atoms of the same element that have different numbers of neutrons and therefore different mass numbers. 11  Practice Atomic number =…………… Mass number =…………….. Number of electrons =…….. Number of neutrons = …….. 12  Shells Sub-Shells and Orbitals4f 4d 4s 3p 3d 2p 1s + [ n=1 K shell 2 electrons [ n=2 [ L shell [ 8 electrons n=3 M shell 18 electrons n=4 N shell 32 electrons Energy  Principal Energy Levels (shells) (n) Principal Energy Levels (shells) (n) Contain electrons that are close in energy. Have values of n = 1, 2, 3, 4, 5, 6….. The 1st shell (n = 1) is the lowest in energy, 2nd level is higher, and so on 1< 2 < 3 < 4 Maximum number of electrons = 2n2 n =1 2(1)2 = 2 n =2 2(2)2 =8 n=3 ????? 14  Sub energy levels (Subshells) ❑Sublevel energy: s