Lab. Physical Pharmacy I - Lab 3 - Three Component Systems - Al-Maarif University - PDF

Al-Maarif University College of Pharmacy Lab. Physical pharmacy I Level: 2nd Class, 1st Semester Lab. 3 Three Component Systems ‫ محمد قحطان كنعان‬.‫م‬.‫ م‬:‫مشرف المختبر‬ ‫ عبدالوهاب محمود عبدالعزيز‬.‫م‬.‫ م‬:‫التدريسي‬  The Comparison Betwee...

Al-Maarif University College of Pharmacy Lab. Physical pharmacy I Level: 2nd Class, 1st Semester Lab. 3 Three Component Systems ‫ محمد قحطان كنعان‬.‫م‬.‫ م‬:‫مشرف المختبر‬ ‫ عبدالوهاب محمود عبدالعزيز‬.‫م‬.‫ م‬:‫التدريسي‬  The Comparison Between two Component and Three Component System: Two component system Three component system 1 Two materials Three materials 2 Drawn on ordinary graph paper Drawn on triangular graph paper Factors affecting are temp. and The experiment is done under constant 3 concentration pressure and temperature 4 The tie line is always parallel to base line The tie line may be parallel or not 5 Example phenol/water system Example HAC,CHCl3,H2O system Rules Relating To Triangular Diagram: 1. Each of the corners or apexes of triangle represent 100% by wt. of one component (A,B & C ) as a result , the same apex will represents 0% of the other two components:  2. The three lines joining the corner points represent two component mixture of the three possible combination of A,B&C. Three component phase diagram (above): Blue point M: X = 40%w/w, Z = 60%w/w Red point F: X = 50%w/w, Y = 50%w/w Black point N: Y = 70%w/w, Z = 30%w/w  3. The area within the triangle represents all possible combinations of A, B&C to give three component systems. Three component phase diagram (above): Red point M: X = 50%w/w , Z = 20%w/w and Y=100-(50+20)=30 %w/w  4. If a line is drawn through any apex to a point on the opposite side, then all systems represented by points on such line have constant ratio of two components. Three component phase diagram (above):  Red point M: X = 60%w/w , Z = 20%w/w and Y=100-(60+20)=20 %w/w ratio y/z=20/20=1  Green point A: X = 20%w/w , Z = 40%w/w and Y=100-(20+40)=40 %w/w ratio y/z=40/40=1  5. Any line drawn parallel to one side of the triangle represents ternary systems in which the proportion ( or % by wt) of one component is constant. Three component phase diagram (above): Point M: X = 40%w/w , Z = 30%w/w and Y=100-(40+30)=30 %w/w Point K: X = 40%w/w , Z = 50%w/w and Y=100-(40+50)=10 %w/w For Example The area within the triangle represents all the possible combinations of A, B and C to give three-component systems. Find the percent of B,D,J,X,F,M and W. ___________________________________________________ Material and equipment  Acetic acid  Chloroform  Distal water  Conical flask  Burette Procedure 1. Prepare 10 g of the following combination of HAC & CHCl3:5%, 10%, 20%, 30%, 40%, 50%, 60%,70%, 80%, and 90% w/w HAC:CHCl3 in a small clean &dry flask which form one single phase. 2. To these mixtures slowly add water from a burette until a turbidity just appears. Check the weight of water (which is equal to its volume). 3. Obtain a miscibility curve by calculating the percent w/w of each component in the turbid mixture and plot this triangular diagram. Note:-To prepare samples in step no.1, the required amount of HAC&CHCl3 from burettes by converting the weight in to volume according to the law: Specific gravity (sp.gr) = weight/volume Sp.gr of HAC =1.009 and for CHCl3 =1.3 For example Group no. 1 if the amount of water consumed for turbidity just appears =0.5ml Total weight of the system= wt of HAC+ wt of CHCL3 +wt of H20 =0.5gm +9.5gm+0.5gm =10.5gm FOR HAC: 0.5/10.5*100=4.76%w/w FOR CHCl3: 9.5/10.5*100=90.5%w/w FOR H2O: 0.5/10.5*100=4.76%w/w Al-Maarif University College Department of Pharmacy Laboratory Physical pharmacy I 3 Student’s Name: Group Title: -------------------------------------------------------------------------------------------- Materials: -------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- Calculations: ---------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------