Histology of RBCs & Erythropoiesis MCQ Quiz PDF

Histology of RBCs & Erythropoiesis MCQ Quiz Medium Difficulty 1. What is the normal shape of a red blood cell (RBC) as seen in a stained blood smear? ○ a) Biconvex disc ○ b) Biconcave disc ○ c) Sphere ○ d) Sickle-shaped 2. What is the advantage of the biconcave shape of RBCs? ○ a) It inc...

Histology of RBCs & Erythropoiesis MCQ Quiz Medium Difficulty 1. What is the normal shape of a red blood cell (RBC) as seen in a stained blood smear? ○ a) Biconvex disc ○ b) Biconcave disc ○ c) Sphere ○ d) Sickle-shaped 2. What is the advantage of the biconcave shape of RBCs? ○ a) It increases the cell's volume. ○ b) It facilitates gas exchange. ○ c) It makes the cell more rigid. ○ d) It slows down the cell's movement. 3. Which of the following is an abnormal shape of RBCs associated with an inherited disease? ○ a) Biconcave disc ○ b) Sickle-shaped ○ c) Cuplike shape ○ d) Rouleaux formation 4. What is the normal diameter range of RBCs? ○ a) 4-6 μm ○ b) 6-9 μm ○ c) 9-12 μm ○ d) 12-15 μm 5. What is the normal concentration of RBCs in blood for males? ○ a) 3.9- 5.5 million/ μL ○ b) 4.1- 6.0 million/ μL ○ c) 4.5- 6.5 million/ μL ○ d) 5.0- 7.0 million/ μL 6. What percentage of the RBC cell membrane is composed of proteins? ○ a) 10% ○ b) 40% ○ c) 50% ○ d) 60% 7. Which protein network provides structural support and flexibility to the RBC membrane? ○ a) Spectrin, ankyrin, and actin ○ b) Collagen, elastin, and fibronectin ○ c) Tubulin, dynein, and kinesin ○ d) Myosin, tropomyosin, and troponin 8. What is the primary source of energy for RBCs? ○ a) Oxidative phosphorylation ○ b) Anaerobic glycolysis ○ c) Fatty acid oxidation ○ d) Krebs cycle 9. What is the average lifespan of an RBC?  ○ a) 30 days ○ b) 60 days ○ c) 90 days ○ d) 120 days 10. Which cells are responsible for removing dead or worn-out RBCs from circulation? ○ a) Neutrophils ○ b) Lymphocytes ○ c) Macrophages ○ d) Eosinophils 11. What is the term for the process of blood cell formation? ○ a) Hemostasis ○ b) Hemolysis ○ c) Hemopoiesis ○ d) Hematopoiesis 12. In adults, where does hemopoiesis primarily occur? ○ a) Liver and spleen ○ b) Yolk sac ○ c) Bone marrow ○ d) Thymus 13. All blood cells are derived from which type of cell? ○ a) Pluripotential hemopoietic stem cell ○ b) Myeloid stem cell ○ c) Lymphoid stem cell ○ d) Progenitor cell 14. Which type of progenitor cell gives rise to lymphocytes? ○ a) Myeloid stem cell ○ b) Lymphoid stem cell ○ c) CFU-GM ○ d) CFU-E 15. What is the first precursor cell in the erythropoiesis lineage? ○ a) Reticulocyte ○ b) Proerythroblast ○ c) Basophilic erythroblast ○ d) Orthochromatophilic erythroblast 16. Which of the following is NOT a characteristic of a mature erythrocyte? ○ a) No nucleus ○ b) Acidophilic cytoplasm ○ c) Presence of ribosomes ○ d) Biconcave shape 17. What is the term for an increase in the proportion of reticulocytes in circulating blood? ○ a) Anemia ○ b) Polycythemia ○ c) Reticulocytosis ○ d) Leukocytosis 18. Reticulocytes make up approximately what percentage of total RBCs in peripheral blood? ○ a) 0.1%  ○ b) 1% ○ c) 5% ○ d) 10% 19. Which stain is a mixture of acidic and basic dyes used to stain blood smears? ○ a) Leishman's stain ○ b) Giemsa stain ○ c) Wright stain ○ d) Hematoxylin and eosin stain 20. What is the term for the stacks of RBCs that may adhere to one another? ○ a) Rouleaux ○ b) Agglutination ○ c) Coagulation ○ d) Hemolysis Difficult Difficulty 21. Which of the following statements about the structure of RBCs is FALSE? ○ a) RBCs lack a nucleus and cell organelles. ○ b) RBCs are densely filled with hemoglobin molecules. ○ c) RBCs rely on aerobic glycolysis for energy production ○ d) The RBC membrane is highly flexible with a supporting cytoskeleton 22. Which of the following is NOT a site of hemopoiesis in the fetus? ○ a) Yolk sac ○ b) Liver ○ c) Spleen ○ d) Thymus 23. Which of the following is a characteristic of a proerythroblast? ○ a) Small size ○ b) Acidophilic cytoplasm ○ c) Condensed nucleus ○ d) Active nucleus 24. Which stage of erythropoiesis is characterized by the extrusion of the nucleus? ○ a) Basophilic erythroblast ○ b) Polychromatophilic erythroblast ○ c) Orthochromatophilic erythroblast ○ d) Reticulocyte 25. Which of the following conditions is associated with RBCs larger than 9 μm in diameter? ○ a) Microcytic anemia ○ b) Macrocytic anemia ○ c) Spherocytosis ○ d) Sickle cell disease 26. Which of the following statements about reticulocytes is TRUE? ○ a) They lack mitochondria. ○ b) They have a condensed nucleus ○ c) They contain a reticulum of ribosomal RNA ○ d) They make up about 10% of total RBCs in peripheral blood 27. Which of the following is NOT a function of the RBC membrane's cytoskeleton?  ○ a) Providing structural support ○ b) Facilitating gas exchange ○ c) Maintaining cell shape ○ d) Enabling flexibility 28. Which of the following is NOT a type of Romanowsky stain? ○ a) Leishman's stain ○ b) Giemsa stain ○ c) Wright stain ○ d) Neutral red stain 29. Which of the following is NOT a characteristic of sickle-shaped RBCs? ○ a) Less flexible ○ b) More fragile ○ c) Short life span ○ d) Decreased blood viscosity 30. Which of the following is NOT a stage in the differentiation of a pluripotential hemopoietic stem cell into a mature erythrocyte? ○ a) CFU-E ○ b) Proerythroblast ○ c) CFU-GM ○ d) Reticulocyte 31. In which stage of erythropoiesis does the cytoplasm exhibit both basophilia and acidophilia? ○ a) Basophilic erythroblast ○ b) Polychromatophilic erythroblast ○ c) Orthochromatophilic erythroblast ○ d) Reticulocyte 32. Which of the following best describes the change in nuclear activity during erythropoiesis? ○ a) It increases progressively. ○ b) It decreases progressively ○ c) It remains constant ○ d) It fluctuates randomly 33. Which of the following is the correct order of erythropoietic stages from least to most mature? ○ a) Proerythroblast, Basophilic erythroblast, Polychromatophilic erythroblast, Orthochromatophilic erythroblast, Reticulocyte, Mature erythrocyte ○ b) Mature erythrocyte, Reticulocyte, Orthochromatophilic erythroblast, Polychromatophilic erythroblast, Basophilic erythroblast, Proerythroblast ○ c) Proerythroblast, Orthochromatophilic erythroblast, Basophilic erythroblast, Polychromatophilic erythroblast, Reticulocyte, Mature erythrocyte ○ d) Reticulocyte, 34. What shape do RBCs adopt when passing through small blood vessels? ○ a) Biconcave disc ○ b) Sickle-shaped  ○ c) Cuplike shape ○ d) Rouleaux formation 35. Which of the following describes the thickness of an RBC? ○ a) Uniform thickness throughout ○ b) Thicker at the rim, thinner in the center ○ c) Thinner at the rim, thicker in the center ○ d) Varies randomly 36. What is the function of antigens on the RBC surface? ○ a) Gas exchange ○ b) Flexibility ○ c) Energy production ○ d) Blood group determination 37. Where are dead or worn-out RBCs primarily removed from circulation? ○ a) Bone marrow ○ b) Spleen, liver, and bone marrow ○ c) Lungs ○ d) Kidneys 38. Which of the following is NOT a site of hemopoiesis in adults? ○ a) Vertebrae ○ b) Ribs ○ c) Liver ○ d) Sternum 39. Which cells are responsible for maintaining the population of hemopoietic stem cells? ○ a) Progenitor cells  ○ b) Pluripotential hemopoietic stem cells themselves ○ c) Macrophages ○ d) Lymphocytes 40. Which of the following cells gives rise to platelets? ○ a) CFU-GM ○ b) CFU-E ○ c) CFU-Meg ○ d) CFU-L Answer Guide 1. b 2. b 3. b 4. b 5. b 6. c 7. a 8. b 9. d 10. c 11. d 12. c 13. a 14. b 15. b 16. c 17. c 18. b 19. a 20. a 21. c 22. d 23. d 24. c 25. b 26. c 27. b 28. d 29. d 30. c 31. b 32. b 33. a 34. c 35. b 36. d 37. b 38. c 39. b 40. c Done