Inherited Coagulation Disorders PDF
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Uploaded by VersatileWisdom5978
UMST
Dr.Sahar Gamal Elbager
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Summary
This document presents lecture notes on inherited coagulation disorders, specifically focusing on hemophilia A, B, and C. It covers definitions, inheritance patterns, frequencies, and clinical aspects of these conditions. The document also includes information about the factors involved and the associated laboratory findings.
Full Transcript
INHERITED COAGULATION DISORDERS Presented by Dr.Sahar Gamal Elbager Ph.D in Haematology UMST 1 INHERITED COAGULATION DISORDERS Coagulation disorders may be inherited or acquired. The inherited disorders are uncommon and usually involve deficienc...
INHERITED COAGULATION DISORDERS Presented by Dr.Sahar Gamal Elbager Ph.D in Haematology UMST 1 INHERITED COAGULATION DISORDERS Coagulation disorders may be inherited or acquired. The inherited disorders are uncommon and usually involve deficiency of one factor only. Inherited coagulation disorders result from qualitative or quantitative abnormality of a coagulation factor Dr.Sahar Elbager-UMST 2 Coagulation factor disorders Inherited bleeding Acquired bleeding disorders disorders Common: – Liver disease – Hemophilia A and B – Vitamin K deficiency – vonWillebrands /warfarin overdose disease – DIC Rare: - Other factor deficiencies Dr.Sahar Elbager-UMST 3 Hemophilia Hemophilia is a group of hereditary genetic disorders that impair the body's ability to control blood clotting or coagulation, which is used to stop bleeding when a blood vessel is broken. Dr.Sahar Elbager-UMST 4 Hemophilia A and B Hemophilia A Hemophilia B Coagulation factor deficiency Factor VIII Factor IX Inheritance X-linked X-linked recessive recessive Incidence 1/5000 males 1/ 20,000–34,000 males Severity Related to factor level
