Important Cytokines PDF
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Summary
This document describes the role of several types of cytokines and their impact on various immune responses. Focuses on the secretion, by various cells, and effects of each substance. Key examples and relationships are provided.
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Cytokine Secreted by Effect IL-1 Macrophages Systemic effect of acute Inflammation IL-2 T-cells T-cell activation & proliferation IL-4 Th2 cells...
Cytokine Secreted by Effect IL-1 Macrophages Systemic effect of acute Inflammation IL-2 T-cells T-cell activation & proliferation IL-4 Th2 cells Promotes Th2 response & suppresses Th1 response; Important role in allergy and defense against parasites IL-6 Macrophages Systemic effect of acute Inflammation IL-12 Dendritic Promotes Th1 response cells/Macrophages IL-13 Th2 cells Increases mucous production; role in defense against parasites IL-17 Th17 cells Protection against extracellular bacteria at mucosal surfaces IL-31 Th2 cells Promotes itching in atopic dermatitis TNF-α Macrophages Systemic effect of acute Inflammation TGF-β Th2 cells Isotype switching to IgA Interferon-α/β Several cell types Antiviral function; NK cell activation Interferon-γ Th1 cells Promotes Th1 response & suppresses Th2 response; important role in defense against intracellular pathogens
