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. primary fibrinolysis relieving primary problem maintaining adequate perfusion if with active bleeding , initiate fresh frozen plasma cryoprecipitate O treatment O O following prostate resection polycythemia O O spontaneous fibrinogen concentrates platelet concentrates heparin therapy O arterial ve...

. primary fibrinolysis relieving primary problem maintaining adequate perfusion if with active bleeding , initiate fresh frozen plasma cryoprecipitate O treatment O O following prostate resection polycythemia O O spontaneous fibrinogen concentrates platelet concentrates heparin therapy O arterial venous O O MYELOPROLIFERATIVE DISEASES urokinase is released during surgical manipulation or in patients undergoing extracorporeal bypass antifibrinolytic agents excess red blood cells thromboembolism · severe purpura fulminans E - aminocaproic acid tranexamic acid spontaneous hemorrhage treatment. low - dose aspirin thrombosis phlebotomy hydroxyurea coagulopathy of liver disease Coagulation factors synthesized by the liver Vitamin K - dependent factors : II ( prothrombin factor ) , VII , IX , X Fibrinogen Factor V or hypercoagulability Factor VIII Factors XI , XII , XIII Antithrombin III Plasminogen Protein C and protein S O increased bleeding risk and increased thrombotic risk O thrombocytopenia and impaired humoral coagulation function prolongation of prothrombin time and international normalized ratio or INR most common coagulation abnormalities associated with liver dysfunction and O O diagnostics Thrombin Activation TAFI O management. ▪ thromboembolism despite thrombocytopenia thromboelastography or TEG frequently performed ; will provide better assessment of bleeding risks compared to standard tests of hemostasis low - platelet count ; due to hypersplenism platelet transfusion splenectomy embolization Shock olism is acute coagulopathy of trauma , ACOT , or ATC Central role of thrombomodulin in acute traumatic coagulopathy ( ATC ) Hypoperfusion hypersplenism vitamin K administration fresh frozen plasma cryoprecipitate reduced production of thrombopoietin immune - mediated destruction of platelets ↑ Thrombomodulin * Thrombomodulin / Thrombin complex Activation of protein C ATC mainstay therapy key initiators or to shock tissue injury Maintains fibrinogen level PAI - 1 Consumption seen Fibrinolysis O trauma - induced coagulopathy splenic reduce O systemic activation of anticoagulant and fibrinolytic pathways · current term used in coagulopathy associated with trauma O mechanism for coagulopathy is an interplay of the following activated protein C - mediated clotting factor deactivation endothelial injury